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学科主题: 临床医学
题名:
Scan-Rescan Reproducibility of Carotid Atherosclerotic Plaque Morphology and Tissue Composition Measurements Using Multicontrast MRI at 3T
作者: Li, Feiyu2; Yarnykh, Vasily L.; Hatsukami, Thomas S.3; Chu, Baocheng; Balu, Niranjan; Wang, Jinnan4; Underhill, Hunter R.; Zhao, Xihai; Smith, Robin; Yuan, Chun1
关键词: carotid artery ; atherosclerosis ; magnetic resonance imaging ; reproducibility ; vessel wall
刊名: JOURNAL OF MAGNETIC RESONANCE IMAGING
发表日期: 2010
DOI: 10.1002/jmri.22014
卷: 31, 期:1, 页:168-176
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: MAGNETIC-FIELD STRENGTHS ; LIPID-LOWERING THERAPY ; HIGH-RESOLUTION ; IN-VIVO ; INVERSION-RECOVERY ; QUANTITATIVE ASSESSMENT ; INTRAPLAQUE HEMORRHAGE ; MEASUREMENT PRECISION ; 3.0 T ; LESIONS
英文摘要:

Purpose: To evaluate interscan reproducibility of both vessel morphology and tissue composition measurements of carotid atherosclerosis using a fast, optimized, 3T multicontrast protocol.

Materials and Methods: A total of 20 patients with carotid stenosis >15% identified by duplex ultrasound were recruited for two independent 3T MRI (Philips) scaris within one month. A multicontrast protocol including five MR sequences was applied: TOF, T1-/T2-/PD-weighted and magnetization-prepared rapid acquisition gradient-echo (MP-RAGE). Carotid artery morphology (wall volume, lumen volume, total vessel volume, normalized wall index, and mean/maximum wall thickness) and plaque component size (lipid rich/necrotic core, calcification, and hemorrhage) were measured over two time points.

Results: After exclusion of images with poor image quality. 257 matched locations from 18 subjects were available for analysis. For the quantitative carotid morphology measurements. coefficient of variation (CV) ranged from 2% to 15% and intraclass correlation coefficient (ICC) ranged from 0.87 to 0.99. Except for maximum wall thickness (ICC = 0.87), all ICC were larger than 0.90. For the quantitative plaque composition measurements, the ICC of the volume and relative content of lipid rich/necrotic core and calcification were larger than 0.90 with CV ranging from 22% to 32%.

Conclusion: The results from the multicontrast high-resolution 3T MR study show high reliability for carotid morphology and plaque component measurements. 3T MRI is a reliable tool for longitudinal clinical trials, with shorter scan time compared to 1.5T.

语种: 英语
项目资助者: Pfizer, Groton, CN, USA
WOS记录号: WOS:000273336100021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61625
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.Philips Res N Amer, Clin Sites Res Program, New York, NY USA
2.Univ Washington, Dept Radiol, Vasc Imaging Lab, Seattle, WA 98109 USA
3.Peking Univ, Hosp 1, Dept Radiol, Beijing 100871, Peoples R China
4.Univ Washington, Dept Surg, Seattle, WA 98109 USA

Recommended Citation:
Li, Feiyu,Yarnykh, Vasily L.,Hatsukami, Thomas S.,et al. Scan-Rescan Reproducibility of Carotid Atherosclerotic Plaque Morphology and Tissue Composition Measurements Using Multicontrast MRI at 3T[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2010,31(1):168-176.
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