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Connexin43 Hemichannels Contribute to Cadmium-Induced Oxidative Stress and Cell Injury
Fang, Xin2; Huang, Tao; Zhu, Ying; Yan, Qiaojing; Chi, Yuan; Jiang, Jean X.3; Wang, Peiyu4; Matsue, Hiroyuki5; Kitamura, Masanori; Yao, Jian1
刊名ANTIOXIDANTS & REDOX SIGNALING
2011-06-01
DOI10.1089/ars.2010.3150
14期:12页:2427-2439
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]JUNCTIONAL INTERCELLULAR COMMUNICATION ; UNFOLDED PROTEIN RESPONSE ; GAP-JUNCTION ; INDUCED APOPTOSIS ; OXIDANT STRESS ; LLC-PK1 CELLS ; ATP RELEASE ; E-CADHERIN ; ACTIVATION ; ASTROCYTES
英文摘要

We investigated the potential involvement of connexin hemichannels in cadmium ions (Cd2+)-elicited cell injury. Transfection of LLC-PK1 cells with a wild-type connexin43 (Cx43) sensitized them to Cd2+-elicited cell injury. The cell susceptibility to Cd2+ was increased by depletion of glutathione (GSH) with DL-buthionine-[S, R]sulfoximine, and decreased by N-acetyl-cysteine or glutathione reduced ethyl ester. Fibroblasts derived from Cx43 wild-type (Cx43+/+) and knockout (Cx43-/-) fetal littermates displayed different susceptibility to Cd2+. Cd2+ induced a higher concentration of reactive oxygen species, a stronger activation c-Jun N-terminal kinase, and significantly more severe cell injury in Cx43+/+ fibroblasts, as compared with Cx43-/-fibroblasts. Cd2+ caused a reduction in intracellular GSH, whereas it elevated extracellular GSH. This effect of Cd2+ was more dramatic in Cx43+/+ than Cx43-/- fibroblasts. Treatment of Cx43+/+ fibroblasts with Cd2+ caused a Cx43 hemichannel-dependent influx of Lucifer Yellow and efflux of ATP. Collectively, our study demonstrates that Cx43 sensitizes cells to Cd2+-initiated cytotoxicity, possibly through hemichannel-mediated effects on intracellular oxidative status. Antioxid. Redox Signal. 14, 2427-2439.

语种英语
WOS记录号WOS:000290783700009
项目编号17659255 ; 20590953 ; B21390324 ; AR 46798 ; AQ-1507
资助机构Ministry of Education, Culture, Sports, Science and Technology, Japan ; Takeda Science Foundation ; Japan-China Medical Association ; University of Yamanashi ; National Institute of Health ; Welch Foundation
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61631
专题北京大学公共卫生学院
作者单位1.Chiba Univ, Sch Med, Dept Dermatol, Chiba 280, Japan
2.Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Mol Signaling, Chuo Ku, Yamanashi 4093898, Japan
3.Inner Mongolia Med Coll, Sch Basic Med Sci, Hohhot, Peoples R China
4.Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA
5.Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Fang, Xin,Huang, Tao,Zhu, Ying,et al. Connexin43 Hemichannels Contribute to Cadmium-Induced Oxidative Stress and Cell Injury[J]. ANTIOXIDANTS & REDOX SIGNALING,2011,14(12):2427-2439.
APA Fang, Xin.,Huang, Tao.,Zhu, Ying.,Yan, Qiaojing.,Chi, Yuan.,...&Yao, Jian.(2011).Connexin43 Hemichannels Contribute to Cadmium-Induced Oxidative Stress and Cell Injury.ANTIOXIDANTS & REDOX SIGNALING,14(12),2427-2439.
MLA Fang, Xin,et al."Connexin43 Hemichannels Contribute to Cadmium-Induced Oxidative Stress and Cell Injury".ANTIOXIDANTS & REDOX SIGNALING 14.12(2011):2427-2439.
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