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学科主题: 基础医学
题名:
The neuropeptide catestatin promotes vascular smooth muscle cell proliferation through the Ca2+-calcineurin-NFAT signaling pathway
作者: Guo, Xiaoxia2; Zhou, Chunyan1; Sun, Ningling2
关键词: Catestatin ; Vascular smooth muscle ; Proliferation ; Calcium ; Calcineurin ; NFAT
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2011-04-22
DOI: 10.1016/j.bbrc.2011.03.104
卷: 407, 期:4, 页:807-812
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: RECEPTOR TYROSINE KINASE ; ACTIVATED T-CELLS ; CHROMOGRANIN-A ; PEPTIDE CATESTATIN ; NUCLEAR FACTOR ; SUBSTANCE-P ; IN-VIVO ; MIGRATION ; SECRETONEURIN ; HYPERTENSION
英文摘要:

The Chromogranin A-derived neuropeptide catestatin is an endogenous nicotinic cholinergic antagonist that acts as a pleiotropic hormone. Since catestatin shares several functions with other members derived from the chromogranin/secretogranin protein family and other neuropeptides which exert proliferative effects on vascular smooth muscle cells (VSMCs), we therefore hypothesized that catestatin would regulate VSMC proliferation. The present study demonstrates that catestatin caused a dose-dependent induction of proliferation in rat aortic smooth muscle cells and furthermore evoked a sustained increase in intracellular calcium. This subsequently leaded to enhanced activation of the Ca2+/calmodulin-dependent phosphatase, calcineurin and resulted in an activation of the Ca2+-dependent transcription factor, nuclear factor of activated T cells (NFAT), initiating transcription of proliferative genes. In addition, cyclosporin A (CsA), a potent inhibitor of calcineurin, abrogated catestatin-mediated effect on VSMCs, indicating that the calcineurin-NFAT signaling is strongly required for catestatin-induced growth of VSMCs. The present study establishes catestatin as a novel proliferative cytokine on vascular smooth muscle cells and this effect is mediated by the Ca2+-calcineurin-NFAT signaling pathway. (C) 2011 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 5102040
项目资助者: Beijing Municipal Natural Science Foundation
WOS记录号: WOS:000290240500032
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61635
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100191, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China

Recommended Citation:
Guo, Xiaoxia,Zhou, Chunyan,Sun, Ningling. The neuropeptide catestatin promotes vascular smooth muscle cell proliferation through the Ca2+-calcineurin-NFAT signaling pathway[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,407(4):807-812.
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