IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
The neuropeptide catestatin promotes vascular smooth muscle cell proliferation through the Ca2+-calcineurin-NFAT signaling pathway
Guo, Xiaoxia2; Zhou, Chunyan1; Sun, Ningling2
关键词Catestatin Vascular smooth muscle Proliferation Calcium Calcineurin NFAT
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2011-04-22
DOI10.1016/j.bbrc.2011.03.104
407期:4页:807-812
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]RECEPTOR TYROSINE KINASE ; ACTIVATED T-CELLS ; CHROMOGRANIN-A ; PEPTIDE CATESTATIN ; NUCLEAR FACTOR ; SUBSTANCE-P ; IN-VIVO ; MIGRATION ; SECRETONEURIN ; HYPERTENSION
英文摘要

The Chromogranin A-derived neuropeptide catestatin is an endogenous nicotinic cholinergic antagonist that acts as a pleiotropic hormone. Since catestatin shares several functions with other members derived from the chromogranin/secretogranin protein family and other neuropeptides which exert proliferative effects on vascular smooth muscle cells (VSMCs), we therefore hypothesized that catestatin would regulate VSMC proliferation. The present study demonstrates that catestatin caused a dose-dependent induction of proliferation in rat aortic smooth muscle cells and furthermore evoked a sustained increase in intracellular calcium. This subsequently leaded to enhanced activation of the Ca2+/calmodulin-dependent phosphatase, calcineurin and resulted in an activation of the Ca2+-dependent transcription factor, nuclear factor of activated T cells (NFAT), initiating transcription of proliferative genes. In addition, cyclosporin A (CsA), a potent inhibitor of calcineurin, abrogated catestatin-mediated effect on VSMCs, indicating that the calcineurin-NFAT signaling is strongly required for catestatin-induced growth of VSMCs. The present study establishes catestatin as a novel proliferative cytokine on vascular smooth muscle cells and this effect is mediated by the Ca2+-calcineurin-NFAT signaling pathway. (C) 2011 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000290240500032
项目编号5102040
资助机构Beijing Municipal Natural Science Foundation
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61635
专题北京大学基础医学院
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100191, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Guo, Xiaoxia,Zhou, Chunyan,Sun, Ningling. The neuropeptide catestatin promotes vascular smooth muscle cell proliferation through the Ca2+-calcineurin-NFAT signaling pathway[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,407(4):807-812.
APA Guo, Xiaoxia,Zhou, Chunyan,&Sun, Ningling.(2011).The neuropeptide catestatin promotes vascular smooth muscle cell proliferation through the Ca2+-calcineurin-NFAT signaling pathway.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,407(4),807-812.
MLA Guo, Xiaoxia,et al."The neuropeptide catestatin promotes vascular smooth muscle cell proliferation through the Ca2+-calcineurin-NFAT signaling pathway".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 407.4(2011):807-812.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
The neuropeptide cat(864KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Guo, Xiaoxia]的文章
[Zhou, Chunyan]的文章
[Sun, Ningling]的文章
百度学术
百度学术中相似的文章
[Guo, Xiaoxia]的文章
[Zhou, Chunyan]的文章
[Sun, Ningling]的文章
必应学术
必应学术中相似的文章
[Guo, Xiaoxia]的文章
[Zhou, Chunyan]的文章
[Sun, Ningling]的文章
相关权益政策
暂无数据
收藏/分享
文件名: The neuropeptide catestatin promotes vascular smooth muscle cell proliferation through the Ca2+-calcineurin-NFAT signaling pathway.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。