IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
The neuropeptide catestatin promotes vascular smooth muscle cell proliferation through the Ca2+-calcineurin-NFAT signaling pathway
Guo, Xiaoxia2; Zhou, Chunyan1; Sun, Ningling2
关键词Catestatin Vascular smooth muscle Proliferation Calcium Calcineurin NFAT
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2011-04-22
DOI10.1016/j.bbrc.2011.03.104
407期:4页:807-812
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
资助者Beijing Municipal Natural Science Foundation ; Beijing Municipal Natural Science Foundation
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]RECEPTOR TYROSINE KINASE ; ACTIVATED T-CELLS ; CHROMOGRANIN-A ; PEPTIDE CATESTATIN ; NUCLEAR FACTOR ; SUBSTANCE-P ; IN-VIVO ; MIGRATION ; SECRETONEURIN ; HYPERTENSION
英文摘要

The Chromogranin A-derived neuropeptide catestatin is an endogenous nicotinic cholinergic antagonist that acts as a pleiotropic hormone. Since catestatin shares several functions with other members derived from the chromogranin/secretogranin protein family and other neuropeptides which exert proliferative effects on vascular smooth muscle cells (VSMCs), we therefore hypothesized that catestatin would regulate VSMC proliferation. The present study demonstrates that catestatin caused a dose-dependent induction of proliferation in rat aortic smooth muscle cells and furthermore evoked a sustained increase in intracellular calcium. This subsequently leaded to enhanced activation of the Ca2+/calmodulin-dependent phosphatase, calcineurin and resulted in an activation of the Ca2+-dependent transcription factor, nuclear factor of activated T cells (NFAT), initiating transcription of proliferative genes. In addition, cyclosporin A (CsA), a potent inhibitor of calcineurin, abrogated catestatin-mediated effect on VSMCs, indicating that the calcineurin-NFAT signaling is strongly required for catestatin-induced growth of VSMCs. The present study establishes catestatin as a novel proliferative cytokine on vascular smooth muscle cells and this effect is mediated by the Ca2+-calcineurin-NFAT signaling pathway. (C) 2011 Elsevier Inc. All rights reserved.

语种英语
所属项目编号5102040
资助者Beijing Municipal Natural Science Foundation ; Beijing Municipal Natural Science Foundation
WOS记录号WOS:000290240500032
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61635
Collection北京大学基础医学院
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100191, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Guo, Xiaoxia,Zhou, Chunyan,Sun, Ningling. The neuropeptide catestatin promotes vascular smooth muscle cell proliferation through the Ca2+-calcineurin-NFAT signaling pathway[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,407(4):807-812.
APA Guo, Xiaoxia,Zhou, Chunyan,&Sun, Ningling.(2011).The neuropeptide catestatin promotes vascular smooth muscle cell proliferation through the Ca2+-calcineurin-NFAT signaling pathway.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,407(4),807-812.
MLA Guo, Xiaoxia,et al."The neuropeptide catestatin promotes vascular smooth muscle cell proliferation through the Ca2+-calcineurin-NFAT signaling pathway".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 407.4(2011):807-812.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Guo, Xiaoxia]'s Articles
[Zhou, Chunyan]'s Articles
[Sun, Ningling]'s Articles
百度学术
百度学术Similar articles in
[Guo, Xiaoxia]'s Articles
[Zhou, Chunyan]'s Articles
[Sun, Ningling]'s Articles
必应学术
必应学术Similar articles in
[Guo, Xiaoxia]'s Articles
[Zhou, Chunyan]'s Articles
[Sun, Ningling]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.