IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Differences in Liver Injury and Trophoblastic Mitochondrial Damage in Different Preeclampsia-like Mouse Models
Han, Yi-Wei; Yang, Zi; Ding, Xiao-Yan; Yu, Huan
关键词Liver Mitochondria Preeclampsia Triglyceride Trophoblast
刊名CHINESE MEDICAL JOURNAL
2015-06-20
DOI10.4103/0366-6999.158322
128期:12页:1627-1635
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]FATTY-ACID OXIDATION ; ANTIPHOSPHOLIPID SYNDROME ; PREGNANCY ; INHIBITION ; MICE ; DISORDERS ; RATS
英文摘要

Background: Preeclampsia is a multifactorial disease during pregnancy. Dysregulated lipid metabolism may be related to some preeclampsia. We investigated the relationship between triglycerides (TGs) and liver injury in different preeclampsia-like mouse models and their potential common pathways.

Methods: Preeclampsia-like models (Nw-nitro-L-arginine-methyl ester [L-NAME], lipopolysaccharide [LPS], apolipoprotein C-III [Apo] transgnic mice + L-NAME, beta 2 glycoprotein I [beta GPI]) were used in four experimental groups: L-NAME (LN), LPS, Apo-LN and beta GPI, respectively, and controls received saline (LN-C, LPS-C, Apo-C, beta GPI-C). The first three models were established in preimplantation (PI), early-, mid- and late-gestation (EG, MG and LG). beta GPI and controls were injected before implantation. Mean arterial pressure (MAP), 24-hour urine protein, placental and fetal weight, serum TGs, total cholesterol (TC) and pathologic liver and trophocyte changes were assessed.

Results: MAP and proteinuria were significantly increased in the experimental groups. Placenta and fetal weight in PI, EP and MP subgroups were significantly lower than LP. Serum TGs significantly increased in most groups but controls. TC was not different between experimental and control groups. Spotty hepatic cell necrosis was observed in PI, EG, MG in LN, Apo-LN and beta GPI, but no morphologic changes were observed in the LPS group. Similar trophoblastic mitochondrial damage was observed in every experimental group.

Conclusions: Earlier preeclampsia onset causes a higher MAP and urine protein level, and more severe placental and fetal damage. Preeclampsia-like models generated by varied means lead to different changes in lipid metabolism and associated with liver injury. Trophoblastic mitochondrial damage may be the common terminal pathway in different preeclampsia-like models.

语种英语
WOS记录号WOS:000356503500012
项目编号81370723 ; 7132215
资助机构National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61639
专题北京大学第三临床医学院
作者单位Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Han, Yi-Wei,Yang, Zi,Ding, Xiao-Yan,et al. Differences in Liver Injury and Trophoblastic Mitochondrial Damage in Different Preeclampsia-like Mouse Models[J]. CHINESE MEDICAL JOURNAL,2015,128(12):1627-1635.
APA Han, Yi-Wei,Yang, Zi,Ding, Xiao-Yan,&Yu, Huan.(2015).Differences in Liver Injury and Trophoblastic Mitochondrial Damage in Different Preeclampsia-like Mouse Models.CHINESE MEDICAL JOURNAL,128(12),1627-1635.
MLA Han, Yi-Wei,et al."Differences in Liver Injury and Trophoblastic Mitochondrial Damage in Different Preeclampsia-like Mouse Models".CHINESE MEDICAL JOURNAL 128.12(2015):1627-1635.
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