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学科主题: 临床医学
题名:
Differences in Liver Injury and Trophoblastic Mitochondrial Damage in Different Preeclampsia-like Mouse Models
作者: Han, Yi-Wei; Yang, Zi; Ding, Xiao-Yan; Yu, Huan
关键词: Liver ; Mitochondria ; Preeclampsia ; Triglyceride ; Trophoblast
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2015-06-20
DOI: 10.4103/0366-6999.158322
卷: 128, 期:12, 页:1627-1635
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: FATTY-ACID OXIDATION ; ANTIPHOSPHOLIPID SYNDROME ; PREGNANCY ; INHIBITION ; MICE ; DISORDERS ; RATS
英文摘要:

Background: Preeclampsia is a multifactorial disease during pregnancy. Dysregulated lipid metabolism may be related to some preeclampsia. We investigated the relationship between triglycerides (TGs) and liver injury in different preeclampsia-like mouse models and their potential common pathways.

Methods: Preeclampsia-like models (Nw-nitro-L-arginine-methyl ester [L-NAME], lipopolysaccharide [LPS], apolipoprotein C-III [Apo] transgnic mice + L-NAME, beta 2 glycoprotein I [beta GPI]) were used in four experimental groups: L-NAME (LN), LPS, Apo-LN and beta GPI, respectively, and controls received saline (LN-C, LPS-C, Apo-C, beta GPI-C). The first three models were established in preimplantation (PI), early-, mid- and late-gestation (EG, MG and LG). beta GPI and controls were injected before implantation. Mean arterial pressure (MAP), 24-hour urine protein, placental and fetal weight, serum TGs, total cholesterol (TC) and pathologic liver and trophocyte changes were assessed.

Results: MAP and proteinuria were significantly increased in the experimental groups. Placenta and fetal weight in PI, EP and MP subgroups were significantly lower than LP. Serum TGs significantly increased in most groups but controls. TC was not different between experimental and control groups. Spotty hepatic cell necrosis was observed in PI, EG, MG in LN, Apo-LN and beta GPI, but no morphologic changes were observed in the LPS group. Similar trophoblastic mitochondrial damage was observed in every experimental group.

Conclusions: Earlier preeclampsia onset causes a higher MAP and urine protein level, and more severe placental and fetal damage. Preeclampsia-like models generated by varied means lead to different changes in lipid metabolism and associated with liver injury. Trophoblastic mitochondrial damage may be the common terminal pathway in different preeclampsia-like models.

语种: 英语
所属项目编号: 81370723 ; 7132215
项目资助者: National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation
WOS记录号: WOS:000356503500012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61639
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China

Recommended Citation:
Han, Yi-Wei,Yang, Zi,Ding, Xiao-Yan,et al. Differences in Liver Injury and Trophoblastic Mitochondrial Damage in Different Preeclampsia-like Mouse Models[J]. CHINESE MEDICAL JOURNAL,2015,128(12):1627-1635.
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