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Increasing frequency of idiopathic membranous nephropathy in primary glomerular disease: A 10-year renal biopsy study from a single Chinese nephrology centre
Zhu, Ping1,2,3,4,5; Zhou, Fu-de1,2,3,4; Wang, Su-xia1,2,3,4; Zhao, Ming-hui1,2,3,4,6; Wang, Hai-yan1,2,3,4
关键词idiopathic membranous nephropathy nephrotic syndrome primary glomerular disease renal histopathology
刊名NEPHROLOGY
2015-08-01
DOI10.1111/nep.12542
20期:8页:560-566
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]CHRONIC KIDNEY-DISEASE ; PRIMARY GLOMERULONEPHRITIS ; PREVALENCE ; EPIDEMIOLOGY ; DIAGNOSIS ; EXPOSURE ; PROVEN
英文摘要

AimTo investigate the changing of idiopathic membranous nephropathy (iMN) in China.

MethodsThis study retrospectively analyzed renal disease spectrum of 6049 patients who underwent renal biopsy at Peking University First Hospital from January 2003 to December 2012. The patients were grouped into two periods at a 5-year interval: 2003-2007 (period 1) and 2008-2012 (period 2).

ResultsAmong 6049 renal biopsied patients, 3831 (63.3%) patients were diagnosed as primary glomerular disease (PGD). The proportion of nephrotic syndrome (NS) in PGD was significantly higher in period 2 than that in period 1 (1016/2214 [55.0%] vs 682/1617 [42.2%], P=0.022). The proportion of iMN in PGD increased from 16.8% (217/1617) in period 1 to 29.35% (646/2214) in period 2 in all groups of age (P<0.001). There was no significant difference of clinical characteristics including age, gender, hypertension, serum cholesterol and proteinuria between the two periods (P>0.05). However, in young patients with iMN (14-44 years old), the percentage of renal histopathology stage I and stage II of iMN in PGDs was significantly higher in period 2 than that in period 1 (101/1240 [8.15%] vs 210/1340 [15.7%], P<0.001).

ConclusionOur study suggests that the frequency of iMN in PGD in our referral diagnostic centre has doubled over the past 10 years. The increase of adult iMN is mainly due to the increase of early stages of iMN in young patients.

Summary at a Glance Zhu P etal. have retrospectively analyzed renal disease spectrum of 6049 patients who underwent renal biopsy. The patients were grouped into two periods at a 5-year interval: 2003-2007 (period 1) and 2008-2012 (period 2). The proportion of idiopathic membranous nephropathy increased in primary glomerular diseases from 16.8% in period 1 to 29.35% in period 2 in all groups of age (P<0.001). They also found that this increases mainly due to the increase of early stages of iMN in young patients.

语种英语
WOS记录号WOS:000358451700008
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61641
专题北京大学第一临床医学院_肾脏内科
北京大学第一临床医学院_电镜室
作者单位1.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
4.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
5.Minist Educ China, Key Lab CKD Prevent & Treatment, Beijing 100034, Peoples R China
6.China Three Gorges Univ, Div Renal, Dept Med, Coll Clin Med Sci 1, Yichang, Peoples R China
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GB/T 7714
Zhu, Ping,Zhou, Fu-de,Wang, Su-xia,et al. Increasing frequency of idiopathic membranous nephropathy in primary glomerular disease: A 10-year renal biopsy study from a single Chinese nephrology centre[J]. NEPHROLOGY,2015,20(8):560-566.
APA Zhu, Ping,Zhou, Fu-de,Wang, Su-xia,Zhao, Ming-hui,&Wang, Hai-yan.(2015).Increasing frequency of idiopathic membranous nephropathy in primary glomerular disease: A 10-year renal biopsy study from a single Chinese nephrology centre.NEPHROLOGY,20(8),560-566.
MLA Zhu, Ping,et al."Increasing frequency of idiopathic membranous nephropathy in primary glomerular disease: A 10-year renal biopsy study from a single Chinese nephrology centre".NEPHROLOGY 20.8(2015):560-566.
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