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学科主题: 临床医学
题名:
Increasing frequency of idiopathic membranous nephropathy in primary glomerular disease: A 10-year renal biopsy study from a single Chinese nephrology centre
作者: Zhu, Ping1,2,3,4,5; Zhou, Fu-de1,2,3,4; Wang, Su-xia1,2,3,4; Zhao, Ming-hui1,2,3,4,6; Wang, Hai-yan1,2,3,4
关键词: idiopathic membranous nephropathy ; nephrotic syndrome ; primary glomerular disease ; renal histopathology
刊名: NEPHROLOGY
发表日期: 2015-08-01
DOI: 10.1111/nep.12542
卷: 20, 期:8, 页:560-566
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; PRIMARY GLOMERULONEPHRITIS ; PREVALENCE ; EPIDEMIOLOGY ; DIAGNOSIS ; EXPOSURE ; PROVEN
英文摘要:

AimTo investigate the changing of idiopathic membranous nephropathy (iMN) in China.

MethodsThis study retrospectively analyzed renal disease spectrum of 6049 patients who underwent renal biopsy at Peking University First Hospital from January 2003 to December 2012. The patients were grouped into two periods at a 5-year interval: 2003-2007 (period 1) and 2008-2012 (period 2).

ResultsAmong 6049 renal biopsied patients, 3831 (63.3%) patients were diagnosed as primary glomerular disease (PGD). The proportion of nephrotic syndrome (NS) in PGD was significantly higher in period 2 than that in period 1 (1016/2214 [55.0%] vs 682/1617 [42.2%], P=0.022). The proportion of iMN in PGD increased from 16.8% (217/1617) in period 1 to 29.35% (646/2214) in period 2 in all groups of age (P<0.001). There was no significant difference of clinical characteristics including age, gender, hypertension, serum cholesterol and proteinuria between the two periods (P>0.05). However, in young patients with iMN (14-44 years old), the percentage of renal histopathology stage I and stage II of iMN in PGDs was significantly higher in period 2 than that in period 1 (101/1240 [8.15%] vs 210/1340 [15.7%], P<0.001).

ConclusionOur study suggests that the frequency of iMN in PGD in our referral diagnostic centre has doubled over the past 10 years. The increase of adult iMN is mainly due to the increase of early stages of iMN in young patients.

Summary at a Glance Zhu P etal. have retrospectively analyzed renal disease spectrum of 6049 patients who underwent renal biopsy. The patients were grouped into two periods at a 5-year interval: 2003-2007 (period 1) and 2008-2012 (period 2). The proportion of idiopathic membranous nephropathy increased in primary glomerular diseases from 16.8% in period 1 to 29.35% in period 2 in all groups of age (P<0.001). They also found that this increases mainly due to the increase of early stages of iMN in young patients.

语种: 英语
所属项目编号: 2012CB517702 ; 81321064 ; 2012FFB03708 ; A13301-020
项目资助者: Chinese 973 Project ; Natural Science Fund of China ; Natural Science Foundation of Hubei Province ; Natural Science Foundation of Yichang City
WOS记录号: WOS:000358451700008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61641
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
4.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
5.Minist Educ China, Key Lab CKD Prevent & Treatment, Beijing 100034, Peoples R China
6.China Three Gorges Univ, Div Renal, Dept Med, Coll Clin Med Sci 1, Yichang, Peoples R China

Recommended Citation:
Zhu, Ping,Zhou, Fu-de,Wang, Su-xia,et al. Increasing frequency of idiopathic membranous nephropathy in primary glomerular disease: A 10-year renal biopsy study from a single Chinese nephrology centre[J]. NEPHROLOGY,2015,20(8):560-566.
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