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学科主题: 临床医学
题名:
Differential Deposition of C4d and MBL in Glomeruli of Patients with ANCA-Negative Pauci-Immune Crescentic Glomerulonephritis
作者: Xing, Guang-qun1,2; Chen, Min1; Liu, Gang1; Zheng, Xin1; E, Jie1; Zhao, Ming-hui1
关键词: ANCA-negative ; complement ; histopathology ; pauci-immune ; crescentic glomerulonephritis
刊名: JOURNAL OF CLINICAL IMMUNOLOGY
发表日期: 2010
DOI: 10.1007/s10875-009-9344-2
卷: 30, 期:1, 页:144-156
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: LECTIN COMPLEMENT PATHWAY ; ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES ; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS ; RENAL INVOLVEMENT ; ACTIVATION ; VASCULITIS ; NEPHRITIS ; DISEASE ; PROTEIN ; MYELOPEROXIDASE
英文摘要:

Our previous study suggested involvement of alternative pathway activation of complement in ANCA-positive pauci-immune crescentic glomerulonephritis (CrGN). This study was to investigate the evidence of complement activation in renal biopsy specimens of patients with ANCA-negative pauci-immune CrGN.

Renal biopsy specimens from 12 patients with ANCA-negative pauci-immune CrGN were used to detect the staining of membrane attack complex (MAC), C3d, C4d, mannose-binding lectin (MBL), factor B by immunohistochemistry, and/or immunofluorescence. Renal tissue from eight patients with minimal change disease (MCD) and renal tissue obtained from a normal kidney and the normal parts of a nephrectomized kidney due to renal carcinoma was used as disease and normal controls, respectively.

MAC and C3d could be detected in the active renal lesions of cellular crescents in each of the 12 ANCA-negative CrGN patients but not or scarcely detected in patients with MCD and in normal renal tissue. The deposition of other complement components in the 12 patients was heterogeneous. Although none of them had C1q staining, eight of the 12 were C4d positive and six out of the eight were MBL positive. The remaining four only had evidence of the alternative pathway activation by positive staining of C3d, factor B, and MAC. The staining intensity of C4d and MBL was much higher in dialysis-dependent patients than that in dialysis-independent patients.

Complement activation was involved in renal damage of human ANCA-negative pauci-immune CrGN but with heterogeneous activation pathways. Positive staining of C4d and MBL might be associated with poor renal outcome.

语种: 英语
所属项目编号: 30725034 ; 30972733
项目资助者: National Science Fund for Distinguished Young Scholars ; National Natural Science Fund
WOS记录号: WOS:000274521300019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61647
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Inst Nephrol, Div Renal, Dept Med,Key Lab Renal Dis,Minst Hlth China,Hosp, Beijing 100034, Peoples R China
2.Qingdao Univ, Affiliated Hosp, Div Renal, Dept Med,Med Coll, Qingdao 266003, Peoples R China

Recommended Citation:
Xing, Guang-qun,Chen, Min,Liu, Gang,et al. Differential Deposition of C4d and MBL in Glomeruli of Patients with ANCA-Negative Pauci-Immune Crescentic Glomerulonephritis[J]. JOURNAL OF CLINICAL IMMUNOLOGY,2010,30(1):144-156.
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