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学科主题: 临床医学
题名:
Cervical Epithelial Brightness by Optical Coherence Tomography Can Determine Histological Grades of Cervical Neoplasia
作者: Belinson, Suzanne E.1; Ledford, Katy2; Rasool, Nabila3; Rollins, Andrew4; Wilan, Na5; Wang, Chun5; Rong, Xuan5; Zhang, Wei5; Zhu, Yasha5; Tresser, Nancy6; Wu, RuiFang5; Belinson, Jerome L.1,3
关键词: cervix uteri ; medical imaging ; cervical epithelial neoplasia ; early diagnosis of cancer ; optical coherence tomography
刊名: JOURNAL OF LOWER GENITAL TRACT DISEASE
发表日期: 2013-04-01
DOI: 10.1097/LGT.0b013e31825d7bf0
卷: 17, 期:2, 页:160-166
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology
研究领域[WOS]: Obstetrics & Gynecology
关键词[WOS]: UTERINE CERVIX ; DIAGNOSTIC EFFICACY ; INVASIVE NEOPLASIA ; INTRAEPITHELIAL NEOPLASIA ; SCATTERING COEFFICIENT ; CONFOCAL MICROSCOPY ; VISUAL INSPECTION ; IN-VIVO ; CANCER ; MANAGEMENT
英文摘要:

Objective. The study aimed to determine if the difference in cervical epithelium brightness, as measured by optical coherence tomography (OCT), has potential as a distinguishing characteristic of normal, low-grade, highgrade (cervical intraepithelial neoplasia 2+), and cancer histological findings.

Materials and Methods. Information from 476 women was available for analysis. Demographic information was collected through in-person interview. All participants were human papillomavirus positive and/or had abnormal cytological finding and underwent colposcopy or unaided visual inspection and examination by OCT by quadrant. All women had a minimum of 4 OCT-matched cervical biopsies and endocervical curettage. Two sample t tests were used to measure differences in OCT image brightness by histological grades.

Results. Mean OCT image brightness differed significantly between each preinvasive histological grade and invasive cancer (p < .01 for all comparisons). Brightness as measured by OCT was also able to differentiate between squamous metaplasia and cervical intraepithelial neoplasia 3/cancer; p values were .004 and .003, respectively.

Conclusions. Epithelial brightness is an important component of cervical epithelium diagnosis by OCT, and we plan to add it to our diagnostic mathematical algorithm in all future versions of OCT software.

语种: 英语
所属项目编号: R25 CA100600
项目资助者: US Public Health Service from the National Cancer Institute
WOS记录号: WOS:000316605400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61650
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Prevent Oncol Int Inc, Cleveland Hts, OH USA
2.Univ Toledo, Toledo, OH 43606 USA
3.Cleveland Clin, Womens Hlth Inst, Dept Obstet & Gynecol, Cleveland, OH 44106 USA
4.Case Western Reserve Univ, Cleveland, OH 44106 USA
5.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen, Peoples R China
6.Imalux Corp, Cleveland, OH 44106 USA

Recommended Citation:
Belinson, Suzanne E.,Ledford, Katy,Rasool, Nabila,et al. Cervical Epithelial Brightness by Optical Coherence Tomography Can Determine Histological Grades of Cervical Neoplasia[J]. JOURNAL OF LOWER GENITAL TRACT DISEASE,2013,17(2):160-166.
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