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Prevalence of Neutralizing Factors Against Adeno-Associated Virus Types 2 in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy
Cheng, Yong1; Huang, Lvzhen1; Li, Xiaoxin1; Qi, Huijun1; Zhou, Peng1; Yu, Wenzhen1; Jiang, Yide A.2; Wadsworth, Samuel2; Scaria, Abraham2
关键词Neutralizing factors adeno-associated virus types 2 age related macular degeneration polypoidal choroidal vasculopathy
刊名CURRENT GENE THERAPY
2013-06-01
13期:3页:182-188
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
研究领域[WOS]Genetics & Heredity
关键词[WOS]MEDIATED GENE-TRANSFER ; ENDOTHELIAL GROWTH-FACTOR ; RETINAL-PIGMENT EPITHELIUM ; INTRAVITREAL BEVACIZUMAB ; PHOTODYNAMIC THERAPY ; VISUAL IMPAIRMENT ; JAPANESE PATIENTS ; IMMUNE-RESPONSES ; VIRAL VECTORS ; ANTIBODIES
英文摘要

Adeno-associated virus type 2 (AAV2) mediated gene therapy providing a potential treatment in the eye. However, immune responses can limit virally mediated gene transfer and therapy. To assess preexisting AAV2 neutralizing factors (NF) titers in peripheral blood and the vitreous in patients with age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV). 130 subjects were enrolled: 50 with neovascular AMD, 30 with PCV, and 50 controls. The serum and the vitreous were obtained for AAV2 NF assay. We found AAV2 NF are present in all of AMD, PCV patients and controls we tested. There were no significant differences in prevalence of NAb in serum between AMD, PCV and controls (P=0.999). There was no correlation between NF in serum and in vitreous (P>0.05), and NF in vitreous was significantly less than in serum. Our results for the first time showed in Chinese population, NF against AAV2 was present in serum of all the patients with AMD or PCV and controls, and there were no significant differences among these groups. Therefore, it demonstrated there were no correlations between AAV2 NF titer and these diseases. We found NF in vitreous was considerably less than in serum in all groups. We also found no direct correlation between NF in vitreous and in serum suggesting serum antibody levels may not be used to predict their counterparts in the vitreous. Our results will provide crucial information for future clinical studies in the development of new therapies based on AAV2 mediated gene delivery in the eye.

语种英语
WOS记录号WOS:000318604400003
项目编号2011CB510200 ; 81100666 ; Z121100005312006
资助机构Genzyme Corporation of USA ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China (NSFC) ; Research Fund for Science and Technology Program of Beijing
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61655
专题北京大学第二临床医学院_眼科
作者单位1.Genzyme Corp, Sanofi Genzyme R&D Ctr, Framingham, MA 01701 USA
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Cheng, Yong,Huang, Lvzhen,Li, Xiaoxin,et al. Prevalence of Neutralizing Factors Against Adeno-Associated Virus Types 2 in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy[J]. CURRENT GENE THERAPY,2013,13(3):182-188.
APA Cheng, Yong.,Huang, Lvzhen.,Li, Xiaoxin.,Qi, Huijun.,Zhou, Peng.,...&Scaria, Abraham.(2013).Prevalence of Neutralizing Factors Against Adeno-Associated Virus Types 2 in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy.CURRENT GENE THERAPY,13(3),182-188.
MLA Cheng, Yong,et al."Prevalence of Neutralizing Factors Against Adeno-Associated Virus Types 2 in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy".CURRENT GENE THERAPY 13.3(2013):182-188.
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