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学科主题: 公共卫生
题名:
CYP1A1 gene polymorphisms in modifying the association between passive smoking and primary dysmenorrhea
作者: Li, Na; Liu, Hong; Chen, Changzhong; Yang, Fan; Li, Zhiping; Fang, Zhian; Wang, Lihua; Hu, Yonghua; Chen, Dafang
关键词: tobacco smoke pollution ; dysmenorrhea ; genetic polymorphism ; cytochrome p-450 ; CYP1A1
刊名: ANNALS OF EPIDEMIOLOGY
发表日期: 2007-11-01
DOI: 10.1016/j.annepidem.2007.05.010
卷: 17, 期:11, 页:882-888
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Public, Environmental & Occupational Health
研究领域[WOS]: Public, Environmental & Occupational Health
关键词[WOS]: ENVIRONMENTAL TOBACCO-SMOKE ; CIGARETTE-SMOKING ; BIRTH-WEIGHT ; YOUNG-WOMEN ; RISK ; EXPOSURE ; CANCER ; MANAGEMENT ; SEVERITY ; PAIN
英文摘要:

PURPOSE: This study investigated whether the association between passive smoking exposure and primary dysmenorrhea is modified by two susceptibility genes, cytochrome P450 1A1 (CYP1A1)MspI and CYP 1A1 HincII.

METHODS: We recruited 1645 female textile workers from 1997 to 2000 in Anqing, China, collecting information about passive smoking and status of primary dysmenorrhea and taking blood samples. We analyzed the association of CYP1A1 gene polymorphisms and passive smoking exposure with primary dysmenorrhea using multiple logistic regression. \ RESULTS: In the passive smoking group, women who had the C/C6235 genotype (odds ratio [OR] = 1.8; 95% confidence intervals [CI] = 1.0-3.3) in CYP1A1MspI and Ile/Ile462 genotype (OR = 2.9; 95% CI = 1.1-7.7) in CYP1A1HincII had increased risk of dysmenorrhea. When stratified by genotype, the adjusted OR of dysmenorrhea was 1.6 (95% CI = 1.2-2.1) for the passive smoking group with the Ile/Ile462 genotype and 1.5 (95% CI = 1.0-2.1) with the C/C6235 genotype, compared with the nonpassive smoking group. The data further showed that there was a significant combined effect between passive smoking and the CYP1A1MspI C/C6235 and HincII Ile/Ile462 genotypes (OR = 2.4; 95% CI = 1.2-4.9).

CONCLUSIONS: CYP1A1MspI and HincII genotypes modified the association between passive smoking and primary dysmenorrhea.

语种: 英语
WOS记录号: WOS:000250939300007
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61659
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Dept Epidemiol & Biostat, Hlth Sci Ctr, Sch Publ Hlth, Beijing 100083, Peoples R China
2.Peking Univ, Minist Educ, Key Lab Epidemiol, Beijing, Peoples R China
3.Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA

Recommended Citation:
Li, Na,Liu, Hong,Chen, Changzhong,et al. CYP1A1 gene polymorphisms in modifying the association between passive smoking and primary dysmenorrhea[J]. ANNALS OF EPIDEMIOLOGY,2007,17(11):882-888.
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