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CYP1A1 gene polymorphisms in modifying the association between passive smoking and primary dysmenorrhea
Li, Na; Liu, Hong; Chen, Changzhong; Yang, Fan; Li, Zhiping; Fang, Zhian; Wang, Lihua; Hu, Yonghua; Chen, Dafang
关键词tobacco smoke pollution dysmenorrhea genetic polymorphism cytochrome p-450 CYP1A1
刊名ANNALS OF EPIDEMIOLOGY
2007-11-01
DOI10.1016/j.annepidem.2007.05.010
17期:11页:882-888
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health
研究领域[WOS]Public, Environmental & Occupational Health
关键词[WOS]ENVIRONMENTAL TOBACCO-SMOKE ; CIGARETTE-SMOKING ; BIRTH-WEIGHT ; YOUNG-WOMEN ; RISK ; EXPOSURE ; CANCER ; MANAGEMENT ; SEVERITY ; PAIN
英文摘要

PURPOSE: This study investigated whether the association between passive smoking exposure and primary dysmenorrhea is modified by two susceptibility genes, cytochrome P450 1A1 (CYP1A1)MspI and CYP 1A1 HincII.

METHODS: We recruited 1645 female textile workers from 1997 to 2000 in Anqing, China, collecting information about passive smoking and status of primary dysmenorrhea and taking blood samples. We analyzed the association of CYP1A1 gene polymorphisms and passive smoking exposure with primary dysmenorrhea using multiple logistic regression. \ RESULTS: In the passive smoking group, women who had the C/C6235 genotype (odds ratio [OR] = 1.8; 95% confidence intervals [CI] = 1.0-3.3) in CYP1A1MspI and Ile/Ile462 genotype (OR = 2.9; 95% CI = 1.1-7.7) in CYP1A1HincII had increased risk of dysmenorrhea. When stratified by genotype, the adjusted OR of dysmenorrhea was 1.6 (95% CI = 1.2-2.1) for the passive smoking group with the Ile/Ile462 genotype and 1.5 (95% CI = 1.0-2.1) with the C/C6235 genotype, compared with the nonpassive smoking group. The data further showed that there was a significant combined effect between passive smoking and the CYP1A1MspI C/C6235 and HincII Ile/Ile462 genotypes (OR = 2.4; 95% CI = 1.2-4.9).

CONCLUSIONS: CYP1A1MspI and HincII genotypes modified the association between passive smoking and primary dysmenorrhea.

语种英语
WOS记录号WOS:000250939300007
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61659
Collection北京大学公共卫生学院
作者单位1.Peking Univ, Dept Epidemiol & Biostat, Hlth Sci Ctr, Sch Publ Hlth, Beijing 100083, Peoples R China
2.Peking Univ, Minist Educ, Key Lab Epidemiol, Beijing, Peoples R China
3.Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA
Recommended Citation
GB/T 7714
Li, Na,Liu, Hong,Chen, Changzhong,et al. CYP1A1 gene polymorphisms in modifying the association between passive smoking and primary dysmenorrhea[J]. ANNALS OF EPIDEMIOLOGY,2007,17(11):882-888.
APA Li, Na.,Liu, Hong.,Chen, Changzhong.,Yang, Fan.,Li, Zhiping.,...&Chen, Dafang.(2007).CYP1A1 gene polymorphisms in modifying the association between passive smoking and primary dysmenorrhea.ANNALS OF EPIDEMIOLOGY,17(11),882-888.
MLA Li, Na,et al."CYP1A1 gene polymorphisms in modifying the association between passive smoking and primary dysmenorrhea".ANNALS OF EPIDEMIOLOGY 17.11(2007):882-888.
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