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学科主题临床医学
Changes in the composition of intestinal fungi and their role in mice with dextran sulfate sodium-induced colitis
Qiu, Xinyun1; Zhang, Feng1; Yang, Xi2; Wu, Na3,4; Jiang, Weiwei1; Li, Xia1; Li, Xiaoxue1; Liu, Yulan1
刊名SCIENTIFIC REPORTS
2015-05-27
DOI10.1038/srep10416
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]INFLAMMATORY BOWEL DISEASES ; CROHNS-DISEASE ; BACTERIAL TRANSLOCATION ; ULCERATIVE-COLITIS ; COMMENSAL FUNGI ; MESENTERIC FAT ; GUT MICROBIOTA ; IMMUNE-SYSTEM ; CANDIDA ; CELLS
英文摘要

Intestinal fungi are increasingly believed to greatly influence gut health. However, the effects of fungi on intestinal inflammation and on gut bacterial constitution are not clear. Here, based on pyrosequencing method, we reveal that fungal compositions vary in different intestinal segments (ileum, cecum, and colon), prefer different colonization locations (mucosa and feces), and are remarkably changed during intestinal inflammation in dextran sulfate sodium (DSS)-colitis mouse models compare to normal controls: Penicillium, Wickerhamomyces, Alternaria, and Candida are increased while Cryptococcus, Phialemonium, Wallemia and an unidentified Saccharomycetales genus are decreased in the guts of DSS-colitis mice. Fungi-depleted mice exhibited aggravated acute DSS-colitis associated with gain of Hallella, Barnesiella, Bacteroides, Alistipes, and Lactobacillus and loss of butyrate-producing Clostridium XIVa, and Anaerostipes compare with normal control. In contrast, bacteria-depleted mice show attenuated acute DSS-colitis. Mice with severely chronic recurrent DSS-colitis show increased plasma (1,3)-beta-D-glucan level and fungal translocation into the colonic mucosa, mesenteric lymph nodes and spleen. This work demonstrate the different roles of fungi in acute and chronic recurrent colitis: They are important counterbalance to bacteria in maintaining intestinal micro-ecological homeostasis and health in acutely inflamed intestines, but can harmfully translocate into abnormal sites and could aggravate disease severity in chronic recurrent colitis.

语种英语
WOS记录号WOS:000355535300001
项目编号801319
资助机构National Nature Science Foundation
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61660
专题北京大学第二临床医学院_消化科
北京大学第三临床医学院_肿瘤治疗中心
作者单位1.Peking Univ, Peoples Hosp, Dept Gastroenterol, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China
3.Peking Univ, Peoples Hosp, Inst Clin Mol Biol, Beijing 100871, Peoples R China
4.Peking Univ, Peoples Hosp, Cent Lab, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Qiu, Xinyun,Zhang, Feng,Yang, Xi,et al. Changes in the composition of intestinal fungi and their role in mice with dextran sulfate sodium-induced colitis[J]. SCIENTIFIC REPORTS,2015,5.
APA Qiu, Xinyun.,Zhang, Feng.,Yang, Xi.,Wu, Na.,Jiang, Weiwei.,...&Liu, Yulan.(2015).Changes in the composition of intestinal fungi and their role in mice with dextran sulfate sodium-induced colitis.SCIENTIFIC REPORTS,5.
MLA Qiu, Xinyun,et al."Changes in the composition of intestinal fungi and their role in mice with dextran sulfate sodium-induced colitis".SCIENTIFIC REPORTS 5(2015).
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