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学科主题: 基础医学
题名:
Analysis of CD137L and IL-17 Expression in Tumor Tissue as Prognostic Indicators for Gliblastoma
作者: Cui, Xiangli1,2; Xu, Zhiqin3; Zhao, Zhigang2; Sui, Dali1; Ren, Xiaohui1; Huang, Qiming4; Qin, Jiazhen5; Hao, Limin4; Wang, Zhenguang4; Shen, Li6,7; Lin, Song1
关键词: CD137L ; Interleukin-17 ; glioblastoma ; overall survival
刊名: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
发表日期: 2013
DOI: 10.7150/ijbs.4891
卷: 9, 期:2, 页:134-141
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
关键词[WOS]: T-CELLS ; 4-1BB LIGAND ; IN-VIVO ; CANCER ; GLIOBLASTOMA ; LYMPHOCYTES ; SURVIVAL ; PROMOTES ; GLIOMA
英文摘要:

Glioblastoma multiforme (GBM) is the most common form of malignant glioma, characterized by genetic instability and unpredictable clinical behavior. GBM is marked by an extremely poor prognosis with median overall survival of 12 similar to 14 months. In this study, we detected the CD137L-expressing cells and IL-17-expressing cells in tumor tissues resected from patients with GBM. Expression of CD137L and IL-17 were assessed by immunohistochemistry, and the prognostic value of CD137L and IL-17 expression within the tumor tissues were assessed by Cox regression and Kaplan-Meier analysis. Immunohistochemical detection showed that positive cells of CD137L and IL-17 in glioblastoma tissue samples were 46.3% (19/41) and 73.2% (30/41) respectively. Expression of CD137L was not correlated with overall survival of GBM patients (P=0.594), while significantly longer survival rate was seen in patients with high expression of IL-17, compared to those with low expression of IL-17 (P=0.007). In addition, we also found that IL-17 expression was significantly correlated with Progression-free survival (PFS) (P=0.016) and death rate (P=0.01). Furthermore, multivariate Cox proportional hazard analyses revealed that IL-17 (P=0.018) and PFS (P=0.028) were independent factors affecting the overall survival probability. Kaplan-Meier analysis showed that PFS of high expression of IL-17 group were significantly longer (P=0.004) than low expression group with GBM. It is concluded that high levels of IL-17 expression in the tumor tissues may be a good prognostic marker for patients with GBM.

语种: 英语
所属项目编号: 7122061
项目资助者: Beijing Natural Science Foundation
WOS记录号: WOS:000315565900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61664
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Beijing Cellonis Biotechnol Co Ltd, Beijing 100085, Peoples R China
2.Peking Univ, Stem Cell Res Ctr, Beijing 100091, Peoples R China
3.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
4.Capital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing 100050, Peoples R China
5.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurosurg, Beijing 100730, Peoples R China
6.Beijing PLA, Mil Gen Hosp, Affiliated Bayi Brain Hosp, Beijing 100700, Peoples R China
7.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100091, Peoples R China

Recommended Citation:
Cui, Xiangli,Xu, Zhiqin,Zhao, Zhigang,et al. Analysis of CD137L and IL-17 Expression in Tumor Tissue as Prognostic Indicators for Gliblastoma[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2013,9(2):134-141.
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