IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
The effect of extract of ginkgo biloba added to haloperidol on superoxide dismutase in inpatients with chronic schizophrenia
Zhang, XY; Zhou, DF; Su, JM; Zhang, PY
刊名JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
2001-02-01
21期:1页:85-88
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]TARDIVE-DYSKINESIA ; RADICALS ; INJURY
英文摘要

The purpose of the study was to evaluate the effect of the classic antipsychotic haloperidol plus extract of ginkgo biloba (EGb) on treatment-resistant chronic schizophrenia and on blood superoxide dismutase (SOD) levels, Eighty-two patients with chronic refractory schizophrenia were studied. Forty-three patients were treated with haloperidol plus extract of ginkgo biloba (group 1), and 39 received haloperidol plus placebo (group 2). SOD levels of these patients were measured before and after treatment and were compared with SOD levels of 30 healthy volunteers. Therapeutic efficiency was equated with a change in clinical rating scores assessed by standardized measurement tools that included the Scale for the Assessment of Positive Symptoms and the Scale for the Assessment of Negative Symptoms (SANS) over this period. Patients in group 1 improved significantly as demonstrated by scores from these two assessment instruments; those in group 2 improved significantly only as shown by scores on SANS. SOD levels before treatment in all patients were significantly higher than those in healthy controls; after treatment, the SOD level decreased significantly in group 1 but not in group 2. These results suggest that EGb may enhance the efficiency of the classic antipsychotic haloperidol in patients with schizophrenia, especially on their positive symptoms, and that EGb may work through an antioxidant effect that is involved in the therapeutic mechanism in patients with chronic refractory schizophrenia.

语种英语
WOS记录号WOS:000166479000014
引用统计
被引频次:68[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61675
专题北京大学精神卫生研究所
作者单位Beijing Med Univ, Inst Mental Hlth, Dept Biochem, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhang, XY,Zhou, DF,Su, JM,et al. The effect of extract of ginkgo biloba added to haloperidol on superoxide dismutase in inpatients with chronic schizophrenia[J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY,2001,21(1):85-88.
APA Zhang, XY,Zhou, DF,Su, JM,&Zhang, PY.(2001).The effect of extract of ginkgo biloba added to haloperidol on superoxide dismutase in inpatients with chronic schizophrenia.JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY,21(1),85-88.
MLA Zhang, XY,et al."The effect of extract of ginkgo biloba added to haloperidol on superoxide dismutase in inpatients with chronic schizophrenia".JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY 21.1(2001):85-88.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, XY]的文章
[Zhou, DF]的文章
[Su, JM]的文章
百度学术
百度学术中相似的文章
[Zhang, XY]的文章
[Zhou, DF]的文章
[Su, JM]的文章
必应学术
必应学术中相似的文章
[Zhang, XY]的文章
[Zhou, DF]的文章
[Su, JM]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。