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学科主题: 精神卫生
题名:
The effect of extract of ginkgo biloba added to haloperidol on superoxide dismutase in inpatients with chronic schizophrenia
作者: Zhang, XY; Zhou, DF; Su, JM; Zhang, PY
刊名: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
发表日期: 2001-02-01
卷: 21, 期:1, 页:85-88
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: TARDIVE-DYSKINESIA ; RADICALS ; INJURY
英文摘要:

The purpose of the study was to evaluate the effect of the classic antipsychotic haloperidol plus extract of ginkgo biloba (EGb) on treatment-resistant chronic schizophrenia and on blood superoxide dismutase (SOD) levels, Eighty-two patients with chronic refractory schizophrenia were studied. Forty-three patients were treated with haloperidol plus extract of ginkgo biloba (group 1), and 39 received haloperidol plus placebo (group 2). SOD levels of these patients were measured before and after treatment and were compared with SOD levels of 30 healthy volunteers. Therapeutic efficiency was equated with a change in clinical rating scores assessed by standardized measurement tools that included the Scale for the Assessment of Positive Symptoms and the Scale for the Assessment of Negative Symptoms (SANS) over this period. Patients in group 1 improved significantly as demonstrated by scores from these two assessment instruments; those in group 2 improved significantly only as shown by scores on SANS. SOD levels before treatment in all patients were significantly higher than those in healthy controls; after treatment, the SOD level decreased significantly in group 1 but not in group 2. These results suggest that EGb may enhance the efficiency of the classic antipsychotic haloperidol in patients with schizophrenia, especially on their positive symptoms, and that EGb may work through an antioxidant effect that is involved in the therapeutic mechanism in patients with chronic refractory schizophrenia.

语种: 英语
WOS记录号: WOS:000166479000014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61675
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: Beijing Med Univ, Inst Mental Hlth, Dept Biochem, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, XY,Zhou, DF,Su, JM,et al. The effect of extract of ginkgo biloba added to haloperidol on superoxide dismutase in inpatients with chronic schizophrenia[J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY,2001,21(1):85-88.
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