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学科主题: 精神卫生
题名:
A hypothesis-driven pathway analysis reveals myelin-related pathways that contribute to the risk of schizophrenia and bipolar disorder
作者: Yu, Hao1,2; Bi, Wenjian3; Liu, Chenxing4; Zhao, Yanlong3; Zhang, Dai1,2,4,5; Yue, Weihua1,2
关键词: Bipolar disorder ; Genome-wide association study ; Myelin ; Pathway-based analysis ; Schizophrenia
刊名: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
发表日期: 2014-06-03
DOI: 10.1016/j.pnpbp.2014.01.006
卷: 51, 页:140-145
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: GENOME-WIDE ASSOCIATION ; CONVERGENT FUNCTIONAL GENOMICS ; POSITIONAL CANDIDATE GENES ; PSYCHIATRIC-DISORDERS ; NETWORK ANALYSIS ; HAN CHINESE ; IDENTIFICATION ; ABNORMALITIES ; POPULATION ; HIGHLIGHTS
英文摘要:

Schizophrenia (SZ) and bipolar disorder (BD) are both severe neuropsychiatric disorders with a strong and potential overlapping genetic background. Multiple lines of evidence, including genetic studies, gene expression studies and neuroimaging studies, have suggested that both disorders are closely related to myelin and oligodendrocyte dysfunctions. In the current study, we hypothesized that the holistic effect of the myelin-related pathway contributes to the genetic susceptibility to both SZ and BD. We extracted pathway data from the canonical pathway database, Gene Ontology (GO), and selected a ′compiled′ pathway based on previous literature. We then performed hypothesis-driven pathway analysis on GWAS data from the Psychiatric Genomics Consortium (PGC). As a result, we identified three myelin-related pathways with a joint effect significantly associated with both disorders: ′Myelin sheath′ pathway (P-SZ = 2.45E-7, P-BD = 1.22E-3), ′Myelination′ pathway (P-SZ = 2.10E-4, P-BD = 2.53E-24), and ′Compiled′ pathway (P-SZ = 4.57E-8, P-BD = 2.61E-9). In comparing the SNPs and genes in these three pathways across the two diseases, we identified a substantial overlap in nominally associated SNPs and genes, which could be susceptibility SNPs and genes for both disorders. From these observations, we propose that myelin-related pathways may be involved in the etiologies of both SZ and BD. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2012BAI01B06 ; 81222017 ; 81221002 ; 91232305 ; NCET-12-0008
项目资助者: National Science and Technology Project ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University
WOS记录号: WOS:000333257800021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61676
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
3.Peking Univ, Inst Mental Hlth, Minist Hlth, Key Lab Mental Hlth,Hosp 6, Beijing 100191, Peoples R China
4.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China
5.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China

Recommended Citation:
Yu, Hao,Bi, Wenjian,Liu, Chenxing,et al. A hypothesis-driven pathway analysis reveals myelin-related pathways that contribute to the risk of schizophrenia and bipolar disorder[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2014,51:140-145.
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