IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
A hypothesis-driven pathway analysis reveals myelin-related pathways that contribute to the risk of schizophrenia and bipolar disorder
Yu, Hao1,2; Bi, Wenjian3; Liu, Chenxing4; Zhao, Yanlong3; Zhang, Dai1,2,4,5; Yue, Weihua1,2
关键词Bipolar disorder Genome-wide association study Myelin Pathway-based analysis Schizophrenia
刊名PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
2014-06-03
DOI10.1016/j.pnpbp.2014.01.006
51页:140-145
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]GENOME-WIDE ASSOCIATION ; CONVERGENT FUNCTIONAL GENOMICS ; POSITIONAL CANDIDATE GENES ; PSYCHIATRIC-DISORDERS ; NETWORK ANALYSIS ; HAN CHINESE ; IDENTIFICATION ; ABNORMALITIES ; POPULATION ; HIGHLIGHTS
英文摘要

Schizophrenia (SZ) and bipolar disorder (BD) are both severe neuropsychiatric disorders with a strong and potential overlapping genetic background. Multiple lines of evidence, including genetic studies, gene expression studies and neuroimaging studies, have suggested that both disorders are closely related to myelin and oligodendrocyte dysfunctions. In the current study, we hypothesized that the holistic effect of the myelin-related pathway contributes to the genetic susceptibility to both SZ and BD. We extracted pathway data from the canonical pathway database, Gene Ontology (GO), and selected a ′compiled′ pathway based on previous literature. We then performed hypothesis-driven pathway analysis on GWAS data from the Psychiatric Genomics Consortium (PGC). As a result, we identified three myelin-related pathways with a joint effect significantly associated with both disorders: ′Myelin sheath′ pathway (P-SZ = 2.45E-7, P-BD = 1.22E-3), ′Myelination′ pathway (P-SZ = 2.10E-4, P-BD = 2.53E-24), and ′Compiled′ pathway (P-SZ = 4.57E-8, P-BD = 2.61E-9). In comparing the SNPs and genes in these three pathways across the two diseases, we identified a substantial overlap in nominally associated SNPs and genes, which could be susceptibility SNPs and genes for both disorders. From these observations, we propose that myelin-related pathways may be involved in the etiologies of both SZ and BD. (C) 2014 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000333257800021
项目编号2012BAI01B06 ; 81222017 ; 81221002 ; 91232305 ; NCET-12-0008
资助机构National Science and Technology Project ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61676
专题北京大学精神卫生研究所
北京大学第一临床医学院_妇产科
北京大学精神卫生研究所_精神科
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
3.Peking Univ, Inst Mental Hlth, Minist Hlth, Key Lab Mental Hlth,Hosp 6, Beijing 100191, Peoples R China
4.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China
5.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Yu, Hao,Bi, Wenjian,Liu, Chenxing,et al. A hypothesis-driven pathway analysis reveals myelin-related pathways that contribute to the risk of schizophrenia and bipolar disorder[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2014,51:140-145.
APA Yu, Hao,Bi, Wenjian,Liu, Chenxing,Zhao, Yanlong,Zhang, Dai,&Yue, Weihua.(2014).A hypothesis-driven pathway analysis reveals myelin-related pathways that contribute to the risk of schizophrenia and bipolar disorder.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,51,140-145.
MLA Yu, Hao,et al."A hypothesis-driven pathway analysis reveals myelin-related pathways that contribute to the risk of schizophrenia and bipolar disorder".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 51(2014):140-145.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yu, Hao]的文章
[Bi, Wenjian]的文章
[Liu, Chenxing]的文章
百度学术
百度学术中相似的文章
[Yu, Hao]的文章
[Bi, Wenjian]的文章
[Liu, Chenxing]的文章
必应学术
必应学术中相似的文章
[Yu, Hao]的文章
[Bi, Wenjian]的文章
[Liu, Chenxing]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。