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学科主题: 基础医学
题名:
Inhalative formaldehyde exposure enhances aggressive behavior and disturbs monoamines in frontal cortex synaptosome of male rats
作者: Liu, Yi1,2; Ye, Zhanlei1,2; Luo, Hanzhi1,2; Sun, Miao1,2; Li, Mi1,2; Fan, Dongsheng3; Chui, Dehua1,2,3
关键词: Dopamine ; Serotonin ; Frontal cortex synaptosome ; Aggression ; Inhalative formaldehyde exposure
刊名: NEUROSCIENCE LETTERS
发表日期: 2009-10-23
DOI: 10.1016/j.neulet.2009.06.037
卷: 464, 期:2, 页:113-116
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: HISTOLOGY TECHNICIANS ; MOUSE ; SENSITIZATION ; INHIBITION ; SEROTONIN ; DOPAMINE ; STRESS ; MICE
英文摘要:

Formaldehyde (FA) exposure is known to be toxic to central nervous system of mammals. In this paper, we evaluated the aggressive behavior after repetitive inhalative FA exposure to male SD rats, and explored the potential mechanism. The rats, ranging from 160 to 180g, were randomly designated into the orchiectomized (ORX) group, the control and the inhalative FA treatment groups. Eight rats underwent orchiectomy surgery. Three days after the orchiectomy surgery, the inhalative FA (monitored to be 13.5 +/- 1.5 ppm) treatment began. We found that the male SD rats, those were exposed to FA showed more aggressive behavior compared to the control. And the ORX rats exhibited less aggressive behavior than the control. Furthermore, the dopamine increased and 5-HT decreased significantly in frontal cortex synaptosome after inhalative FA treatment. It is the first to evaluate aggressive behavior and identified monoamines disturbances in the frontal cortex synaptosome after the repetitive inhalative FA exposure to rodents. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 30570533 ; 30670414 ; 2006CB500705 ; 0060102A4031
项目资助者: National Natural Science Foundation of China ; National Hightech Research and Development program of China
WOS记录号: WOS:000270419400008
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61678
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Minist Publ Hlth, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Publ Hlth, Neurosci Res Inst, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Neurol, Beijing 100191, Peoples R China

Recommended Citation:
Liu, Yi,Ye, Zhanlei,Luo, Hanzhi,et al. Inhalative formaldehyde exposure enhances aggressive behavior and disturbs monoamines in frontal cortex synaptosome of male rats[J]. NEUROSCIENCE LETTERS,2009,464(2):113-116.
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