IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Inhalative formaldehyde exposure enhances aggressive behavior and disturbs monoamines in frontal cortex synaptosome of male rats
Liu, Yi1,2; Ye, Zhanlei1,2; Luo, Hanzhi1,2; Sun, Miao1,2; Li, Mi1,2; Fan, Dongsheng3; Chui, Dehua1,2,3
关键词Dopamine Serotonin Frontal Cortex Synaptosome Aggression Inhalative Formaldehyde Exposure
刊名NEUROSCIENCE LETTERS
2009-10-23
DOI10.1016/j.neulet.2009.06.037
464期:2页:113-116
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者National Natural Science Foundation of China ; National Hightech Research and Development program of China ; National Natural Science Foundation of China ; National Hightech Research and Development program of China
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]HISTOLOGY TECHNICIANS ; MOUSE ; SENSITIZATION ; INHIBITION ; SEROTONIN ; DOPAMINE ; STRESS ; MICE
英文摘要

Formaldehyde (FA) exposure is known to be toxic to central nervous system of mammals. In this paper, we evaluated the aggressive behavior after repetitive inhalative FA exposure to male SD rats, and explored the potential mechanism. The rats, ranging from 160 to 180g, were randomly designated into the orchiectomized (ORX) group, the control and the inhalative FA treatment groups. Eight rats underwent orchiectomy surgery. Three days after the orchiectomy surgery, the inhalative FA (monitored to be 13.5 +/- 1.5 ppm) treatment began. We found that the male SD rats, those were exposed to FA showed more aggressive behavior compared to the control. And the ORX rats exhibited less aggressive behavior than the control. Furthermore, the dopamine increased and 5-HT decreased significantly in frontal cortex synaptosome after inhalative FA treatment. It is the first to evaluate aggressive behavior and identified monoamines disturbances in the frontal cortex synaptosome after the repetitive inhalative FA exposure to rodents. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

语种英语
所属项目编号30570533 ; 30670414 ; 2006CB500705 ; 0060102A4031
资助者National Natural Science Foundation of China ; National Hightech Research and Development program of China ; National Natural Science Foundation of China ; National Hightech Research and Development program of China
WOS记录号WOS:000270419400008
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61678
Collection北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Minist Publ Hlth, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Publ Hlth, Neurosci Res Inst, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Neurol, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Liu, Yi,Ye, Zhanlei,Luo, Hanzhi,et al. Inhalative formaldehyde exposure enhances aggressive behavior and disturbs monoamines in frontal cortex synaptosome of male rats[J]. NEUROSCIENCE LETTERS,2009,464(2):113-116.
APA Liu, Yi.,Ye, Zhanlei.,Luo, Hanzhi.,Sun, Miao.,Li, Mi.,...&Chui, Dehua.(2009).Inhalative formaldehyde exposure enhances aggressive behavior and disturbs monoamines in frontal cortex synaptosome of male rats.NEUROSCIENCE LETTERS,464(2),113-116.
MLA Liu, Yi,et al."Inhalative formaldehyde exposure enhances aggressive behavior and disturbs monoamines in frontal cortex synaptosome of male rats".NEUROSCIENCE LETTERS 464.2(2009):113-116.
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