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学科主题基础医学
Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population
Xiang, Xiaohui1,2,3,4; Jiang, Yin1,2,3; Ni, Yanjun5; Fan, Min5; Shen, Fang1,2,3; Wang, Xuewei1,2,3; Han, Jisheng1,2,3; Cui, Cailian1,2,3
关键词gene polymorphism haplotype analgesia electroacupuncture
刊名PHYSIOLOGICAL GENOMICS
2012-03-01
DOI10.1152/physiolgenomics.00162.2011
44期:5页:318-328
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Genetics & Heredity ; Physiology
资助者National Basic Research Program of China ; National Basic Research Program of China
研究领域[WOS]Cell Biology ; Genetics & Heredity ; Physiology
关键词[WOS]ELECTRICAL NERVE-STIMULATION ; HAPLOTYPE RECONSTRUCTION ; VAL158MET POLYMORPHISM ; GENE POLYMORPHISMS ; EVOKING STIMULI ; SENSITIVITY ; ACUPUNCTURE ; FREQUENCIES ; VARIANT ; ASSOCIATION
英文摘要

Xiang X, Jiang Y, Ni Y, Fan M, Shen F, Wang X, Han J, Cui C. Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population. Physiol Genomics 44: 318-328, 2012. First published January 17, 2012; doi: 10.1152/physiolgenomics.00162.2011.-Polymorphisms in the human catechol-O-methyltransferase (COMT) gene have been widely studied for their role in pain and analgesia. In this study, sensitivity to potassium iontophoresis, visual analog scale measurements for fixed twofold pain threshold stimulation and pain threshold changes induced by transcutaneous electrical acupoint stimulation (TEAS) were assessed in a population of healthy Chinese males. These results were correlated with the alleles of six single nucleotide polymorphisms (SNP) or diplotypes of common haplotypes designated as low pain sensitive, average pain sensitive, and high pain sensitive in the COMT gene of these subjects. Our results reveal that the alleles of each SNP are not significantly correlated with pain perception except for the rs4633 allele in the 2 Hz TEAS session (P < 0.05). In addition, the six diplotypes of COMT haplotypes, which cover 92.5% of the Chinese population, are also not correlated with pain perception. Moreover, there were no significant differences in pain threshold changes induced by 2 and 100 Hz TEAS among the diplotypes of each SNP or the various haplotypes. These results suggest that COMT activity do not play a significant role in pain perception and TEAS-induced analgesia in the Chinese Han male population.

语种英语
所属项目编号2007CB512501 ; 2009CB522003
资助者National Basic Research Program of China ; National Basic Research Program of China
WOS记录号WOS:000301192500004
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61679
专题基础医学院_神经生物学系
作者单位1.Beijing Peoples Armed Police Force, Beijing, Peoples R China
2.Minist Educ, Key Lab Neurosci, Beijing, Peoples R China
3.Minist Publ Hlth, Beijing, Peoples R China
4.Peking Univ, Dept Neurobiol, Neurosci Res Inst, Sch Basic Med Sci, Beijing 100191, Peoples R China
5.Logist Univ Chinese Peoples Armed Police Forces, Dept Physiol & Pathophysiol, Tianjin, Peoples R China
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GB/T 7714
Xiang, Xiaohui,Jiang, Yin,Ni, Yanjun,et al. Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population[J]. PHYSIOLOGICAL GENOMICS,2012,44(5):318-328.
APA Xiang, Xiaohui.,Jiang, Yin.,Ni, Yanjun.,Fan, Min.,Shen, Fang.,...&Cui, Cailian.(2012).Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population.PHYSIOLOGICAL GENOMICS,44(5),318-328.
MLA Xiang, Xiaohui,et al."Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population".PHYSIOLOGICAL GENOMICS 44.5(2012):318-328.
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