IR@PKUHSC  > 基础医学院  > 解剖学与组织胚胎学系
学科主题基础医学
Expression of PC cell-derived growth factor and vascular endothelial growth factor in esophageal squamous cell carcinoma and their clinicopathologic significance
Chen Xiang-yu2; Li Jian-sheng2; Liang Qian-ping2; He De-zhi2; Zhao Jing1
关键词esophageal squamous cell carcinoma PC cell-derived growth factor vascular endothelial growth factor angiogenesis immunohistochemistry
刊名CHINESE MEDICAL JOURNAL
2008-05-20
121期:10页:881-886
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]GRANULIN-EPITHELIN PRECURSOR ; TUMOR-GROWTH ; CANCER CELLS ; IN-VITRO ; PROGRANULIN ; ADENOCARCINOMA ; MIGRATION ; THERAPY ; OVEREXPRESSION ; PROLIFERATION
英文摘要

Background Esophageal carcinoma is a common kind of malignant tumor and about 90% of which is esophageal squamous cell carcinoma (ESCC), and it has a high incidence in China. In recent years it has been argued that angiogenesis plays a key role in tumor growth and metastasis and it is a complex process influenced by many factors. This study was aimed to investigate the expression of PC cell-derived growth factor (PC DGF or progranulin) and vascular endothelial growth factor (VEGF) in ESCC tissue and their relationship with clinical pathological parameters of ESCC, clarify the role of PCDGF and VEGF in the angiogenesis of ESCC.

Methods The expression of PCDGF and VEGF in 50 surgical specimens from patients with ESCC and 20 with normal esophageal mucosa were detected by immunohistochemistry. The vascular endothelial cells in tumor tissues were labeled by antibody to CD105 for counting microvessel density (MVD).

Results The expression of PCDGF and VEGF in ESCC was significantly higher than that in normal mucosa. Expression correlated with the depth of tumor invasion, lymph node metastasis, and TNM (classification tumor, nodes, metastasis). In ESCC, both the expression level of PCDGF and VEGF had a positive correlation with MVD and the expression of PCDGF had a significant correlation with the expression of VEGF.

Conclusions These results show that both of PCDGF and VEGE have higher expression in ESCC, which indicate that they have a close relationship with angiogenesis. They may be involved in tumor growth, infiltration and metastasis through promoting tumor angiogenesis and may be an important index reflecting biological behavior and prognosis of ESCC.

语种英语
WOS记录号WOS:000256255200004
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61682
专题基础医学院_解剖学与组织胚胎学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Anat, Beijing 100083, Peoples R China
2.Zhengzhou Univ, Affiliated Hosp 1, Inst Clin Med Res Henan Province, Dept Digest Dis, Zhengzhou 450052, Henan, Peoples R China
推荐引用方式
GB/T 7714
Chen Xiang-yu,Li Jian-sheng,Liang Qian-ping,et al. Expression of PC cell-derived growth factor and vascular endothelial growth factor in esophageal squamous cell carcinoma and their clinicopathologic significance[J]. CHINESE MEDICAL JOURNAL,2008,121(10):881-886.
APA Chen Xiang-yu,Li Jian-sheng,Liang Qian-ping,He De-zhi,&Zhao Jing.(2008).Expression of PC cell-derived growth factor and vascular endothelial growth factor in esophageal squamous cell carcinoma and their clinicopathologic significance.CHINESE MEDICAL JOURNAL,121(10),881-886.
MLA Chen Xiang-yu,et al."Expression of PC cell-derived growth factor and vascular endothelial growth factor in esophageal squamous cell carcinoma and their clinicopathologic significance".CHINESE MEDICAL JOURNAL 121.10(2008):881-886.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen Xiang-yu]的文章
[Li Jian-sheng]的文章
[Liang Qian-ping]的文章
百度学术
百度学术中相似的文章
[Chen Xiang-yu]的文章
[Li Jian-sheng]的文章
[Liang Qian-ping]的文章
必应学术
必应学术中相似的文章
[Chen Xiang-yu]的文章
[Li Jian-sheng]的文章
[Liang Qian-ping]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。