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学科主题: 基础医学
题名:
Human CMTM2/CKLFSF2 enhances the ligand-induced transactivation of the androgen receptor
作者: Liu DaZhen2,4; Yin CaiHua1; Zhang YingMei3; Tian LinJie1; Li Ting3; Li Dan1; Ma DaLong1,3; Guo YingLu2; Wang Ying1,3
关键词: CMTM2 ; CKLFSF2 ; androgen receptor ; transactivation ; Akt
刊名: CHINESE SCIENCE BULLETIN
发表日期: 2009-03-01
DOI: 10.1007/s11434-009-0092-8
卷: 54, 期:6, 页:1050-1057
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: PROSTATIC-CANCER CELLS ; TUMOR-SUPPRESSOR ; NUCLEAR-RECEPTOR ; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE ; MOLECULAR-CLONING ; BINDING DOMAIN ; COACTIVATOR ; EXPRESSION ; LNCAP ; IDENTIFICATION
英文摘要:

CKLF (chemokine-like factor)-like MARVEL (MAL and related proteins for vesicle trafficking and membrane link domain) transmembrane domain containing (CMTM) is a novel gene family. One member of this family, CMTM2, also named chemokine-like factor superfamily 2 (CKLFSF2), is expressed highly in the testis and moderately in the prostate, marrow and peripheral blood cells. However, the function of human CMTM2 remains unknown. Here, we found that CMTM2 was upregulated in 5 alpha-dihydrotestosterone (DHT)-treated LNCaP cells. We investigated the relationship between CMTM2 and the androgen receptor. Our results showed that CMTM2 enhanced DHT-mediated androgen receptor (AR) transactivation and the expression of prostate specific antigen (PSA). We also observed that CMTM2 enhanced the AR protein level, which was reversed by silencing endogenous CMTM2 expression, which suggested that CMTM2 might play an important role in maintaining the AR protein level. We also found that CMTM2 suppressed Akt activation. A previous study showed that Akt could phosphorylate AR at Ser210 and Ser790 and lead to AR ubiquitylation and degradation as well as suppression of AR activity. Taken together, suppressing Akt activation and increasing the AR protein level might be one of the mechanisms for the CMTM2-mediated enhancement of AR transactivation.

语种: 英语
所属项目编号: 2006AA02A305 ; 2002BA711A01 ; 30271203 ; 30671907
项目资助者: National High Technology Research and Development Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000264174900021
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61683
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Med Immunol, Beijing 100083, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
4.Tianjin Med Univ, Gen Hosp, Dept Urol, Tianjin 300052, Peoples R China

Recommended Citation:
Liu DaZhen,Yin CaiHua,Zhang YingMei,et al. Human CMTM2/CKLFSF2 enhances the ligand-induced transactivation of the androgen receptor[J]. CHINESE SCIENCE BULLETIN,2009,54(6):1050-1057.
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