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学科主题基础医学
Human CMTM2/CKLFSF2 enhances the ligand-induced transactivation of the androgen receptor
Liu DaZhen2,4; Yin CaiHua1; Zhang YingMei3; Tian LinJie1; Li Ting3; Li Dan1; Ma DaLong1,3; Guo YingLu2; Wang Ying1,3
关键词CMTM2 CKLFSF2 androgen receptor transactivation Akt
刊名CHINESE SCIENCE BULLETIN
2009-03-01
DOI10.1007/s11434-009-0092-8
54期:6页:1050-1057
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]PROSTATIC-CANCER CELLS ; TUMOR-SUPPRESSOR ; NUCLEAR-RECEPTOR ; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE ; MOLECULAR-CLONING ; BINDING DOMAIN ; COACTIVATOR ; EXPRESSION ; LNCAP ; IDENTIFICATION
英文摘要

CKLF (chemokine-like factor)-like MARVEL (MAL and related proteins for vesicle trafficking and membrane link domain) transmembrane domain containing (CMTM) is a novel gene family. One member of this family, CMTM2, also named chemokine-like factor superfamily 2 (CKLFSF2), is expressed highly in the testis and moderately in the prostate, marrow and peripheral blood cells. However, the function of human CMTM2 remains unknown. Here, we found that CMTM2 was upregulated in 5 alpha-dihydrotestosterone (DHT)-treated LNCaP cells. We investigated the relationship between CMTM2 and the androgen receptor. Our results showed that CMTM2 enhanced DHT-mediated androgen receptor (AR) transactivation and the expression of prostate specific antigen (PSA). We also observed that CMTM2 enhanced the AR protein level, which was reversed by silencing endogenous CMTM2 expression, which suggested that CMTM2 might play an important role in maintaining the AR protein level. We also found that CMTM2 suppressed Akt activation. A previous study showed that Akt could phosphorylate AR at Ser210 and Ser790 and lead to AR ubiquitylation and degradation as well as suppression of AR activity. Taken together, suppressing Akt activation and increasing the AR protein level might be one of the mechanisms for the CMTM2-mediated enhancement of AR transactivation.

语种英语
WOS记录号WOS:000264174900021
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61683
专题北京大学基础医学院_免疫学系
北京大学第一临床医学院_北京大学泌尿外科研究所
作者单位1.Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Med Immunol, Beijing 100083, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
4.Tianjin Med Univ, Gen Hosp, Dept Urol, Tianjin 300052, Peoples R China
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Liu DaZhen,Yin CaiHua,Zhang YingMei,et al. Human CMTM2/CKLFSF2 enhances the ligand-induced transactivation of the androgen receptor[J]. CHINESE SCIENCE BULLETIN,2009,54(6):1050-1057.
APA Liu DaZhen.,Yin CaiHua.,Zhang YingMei.,Tian LinJie.,Li Ting.,...&Wang Ying.(2009).Human CMTM2/CKLFSF2 enhances the ligand-induced transactivation of the androgen receptor.CHINESE SCIENCE BULLETIN,54(6),1050-1057.
MLA Liu DaZhen,et al."Human CMTM2/CKLFSF2 enhances the ligand-induced transactivation of the androgen receptor".CHINESE SCIENCE BULLETIN 54.6(2009):1050-1057.
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