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学科主题: 临床医学
题名:
Colonoscopy in the diagnosis of intestinal graft versus host disease and cytomegalovirus enteritis following allogeneic haematopoietic stem cell transplantation
作者: He Jin-De1; Liu Yu-Lan; Wang Zhi-Feng1; Liu Dai-Hong2; Chen Huan1,2; Chen Yu-Hong2
关键词: graft versus host disease ; cytomegalovirus ; enteritis ; stem cell transplantation ; colonoscopy
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2008-07-20
卷: 121, 期:14, 页:1285-1289
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; ENDOSCOPIC EVALUATION ; HISTOLOGIC DIAGNOSIS ; DIARRHEA ; COLITIS ; BIOPSY ; NAUSEA ; COLON
英文摘要:

Background Gastrointestinal graft versus host disease (GI-GVHD) and cytomegalovirus (CMV) enteritis are important complications following allogeneic haernatopoietic stem colonoscopy in the diagnosis of GI-GVHD and CM manifestations of GI-GVHD and CMV enteritis was made. cell transplantation (allo-HSCT). We explored the role of V enteritis following allo-HSCT to identify the endoscopic

Methods A retrospective analysis of the colonoscopic manifestations of GI-GVHD, CMV enteritis and Gl-GVHD with concurrent CMV enteritis (GconC) and their related clinical issues.

Results Forty-seven patients underwent 50 colonoscopies with diagnoses of 32 GI-GVHD, 7 CMV enteritis and 11 GconC. Both Gl-GVHD and CMV enteritis had colonic mucosal lesions with various manifestations under colonoscopy. Tortoise shell like changes of the mucosa (12 of 32) and deep ulcers (2 of 7) were specific endoscopic manifestations for Gl-GVHD and CMV enteritis, respectively, while mucosal oedema, erythema, congestion, erosion and shallow ulcers could not be used to differentiate Gl-GVHD from CMV enteritis. GconC patients were prone to have oozing bleeding of the end ileal mucosa and typhlodicliditis. Of the biopsed specimens for GI-GVHD, CMV enteritis and GconC, 64%, 70% and 44% were taken from the rectum and sigmoid colon respectively.

Conclusions Following allo-HSCT, tortoise shell like changes and deep ulcers of the colonic mucosa are characteristic changes for Gl-GVHD and CMV enteritis, respectively, while the other lesions are not. Most of the GI-GVHDs and CMV enteritis cases can be diagnosed by left colon examination and tissue biopsy, but total colon examination to the terminal ileum is preferred.

语种: 英语
WOS记录号: WOS:000257941000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61685
Appears in Collections:北京大学第二临床医学院_消化内科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Gastroenterol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Hematol, Beijing 100044, Peoples R China

Recommended Citation:
He Jin-De,Liu Yu-Lan,Wang Zhi-Feng,et al. Colonoscopy in the diagnosis of intestinal graft versus host disease and cytomegalovirus enteritis following allogeneic haematopoietic stem cell transplantation[J]. CHINESE MEDICAL JOURNAL,2008,121(14):1285-1289.
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