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学科主题临床医学
Colonoscopy in the diagnosis of intestinal graft versus host disease and cytomegalovirus enteritis following allogeneic haematopoietic stem cell transplantation
He Jin-De1; Liu Yu-Lan; Wang Zhi-Feng1; Liu Dai-Hong2; Chen Huan1,2; Chen Yu-Hong2
关键词graft versus host disease cytomegalovirus enteritis stem cell transplantation colonoscopy
刊名CHINESE MEDICAL JOURNAL
2008-07-20
121期:14页:1285-1289
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]BONE-MARROW-TRANSPLANTATION ; ENDOSCOPIC EVALUATION ; HISTOLOGIC DIAGNOSIS ; DIARRHEA ; COLITIS ; BIOPSY ; NAUSEA ; COLON
英文摘要

Background Gastrointestinal graft versus host disease (GI-GVHD) and cytomegalovirus (CMV) enteritis are important complications following allogeneic haernatopoietic stem colonoscopy in the diagnosis of GI-GVHD and CM manifestations of GI-GVHD and CMV enteritis was made. cell transplantation (allo-HSCT). We explored the role of V enteritis following allo-HSCT to identify the endoscopic

Methods A retrospective analysis of the colonoscopic manifestations of GI-GVHD, CMV enteritis and Gl-GVHD with concurrent CMV enteritis (GconC) and their related clinical issues.

Results Forty-seven patients underwent 50 colonoscopies with diagnoses of 32 GI-GVHD, 7 CMV enteritis and 11 GconC. Both Gl-GVHD and CMV enteritis had colonic mucosal lesions with various manifestations under colonoscopy. Tortoise shell like changes of the mucosa (12 of 32) and deep ulcers (2 of 7) were specific endoscopic manifestations for Gl-GVHD and CMV enteritis, respectively, while mucosal oedema, erythema, congestion, erosion and shallow ulcers could not be used to differentiate Gl-GVHD from CMV enteritis. GconC patients were prone to have oozing bleeding of the end ileal mucosa and typhlodicliditis. Of the biopsed specimens for GI-GVHD, CMV enteritis and GconC, 64%, 70% and 44% were taken from the rectum and sigmoid colon respectively.

Conclusions Following allo-HSCT, tortoise shell like changes and deep ulcers of the colonic mucosa are characteristic changes for Gl-GVHD and CMV enteritis, respectively, while the other lesions are not. Most of the GI-GVHDs and CMV enteritis cases can be diagnosed by left colon examination and tissue biopsy, but total colon examination to the terminal ileum is preferred.

语种英语
WOS记录号WOS:000257941000007
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61685
专题北京大学第二临床医学院_消化科
北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Peoples Hosp, Dept Gastroenterol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Hematol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
He Jin-De,Liu Yu-Lan,Wang Zhi-Feng,et al. Colonoscopy in the diagnosis of intestinal graft versus host disease and cytomegalovirus enteritis following allogeneic haematopoietic stem cell transplantation[J]. CHINESE MEDICAL JOURNAL,2008,121(14):1285-1289.
APA He Jin-De,Liu Yu-Lan,Wang Zhi-Feng,Liu Dai-Hong,Chen Huan,&Chen Yu-Hong.(2008).Colonoscopy in the diagnosis of intestinal graft versus host disease and cytomegalovirus enteritis following allogeneic haematopoietic stem cell transplantation.CHINESE MEDICAL JOURNAL,121(14),1285-1289.
MLA He Jin-De,et al."Colonoscopy in the diagnosis of intestinal graft versus host disease and cytomegalovirus enteritis following allogeneic haematopoietic stem cell transplantation".CHINESE MEDICAL JOURNAL 121.14(2008):1285-1289.
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