学科主题基础医学
Y-Like Retinal Ganglion Cells Innervate the Dorsal Raphe Nucleus in the Mongolian Gerbil (Meriones unguiculatus)
Luan, Liju1,2,3; Ren, Chaoran1,2,3; Lau, Benson Wui-Man4,5; Yang, Jian4,5; Pickard, Gary E.6; So, Kwok-Fai4,5,7,8; Pu, Mingliang1,2,3
刊名PLOS ONE
2011-04-28
DOI10.1371/journal.pone.0018938
6期:4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]HYPOTHALAMIC SUPRACHIASMATIC NUCLEUS ; CENTRAL PROJECTIONS ; DIURNAL-VARIATION ; MAMMALIAN RETINA ; MIDBRAIN RAPHE ; LIGHT-FLASHES ; CAT ; MELANOPSIN ; RAT ; MORPHOLOGY
英文摘要

Background: The dorsal raphe nucleus (DRN) of the mesencephalon is a complex multi-functional and multi-transmitter nucleus involved in a wide range of behavioral and physiological processes. The DRN receives a direct input from the retina. However little is known regarding the type of retinal ganglion cell (RGC) that innervates the DRN. We examined morphological characteristics and physiological properties of these DRN projecting ganglion cells.

Methodology/Principal Findings: The Mongolian gerbils are highly visual rodents with a diurnal/crepuscular activity rhythm. It has been widely used as experimental animals of various studies including seasonal affective disorders and depression. Young adult gerbils were used in the present study. DRN-projecting RGCs were identified following retrograde tracer injection into the DRN, characterized physiologically by extracellular recording and morphologically after intracellular filling. The result shows that DRN-projecting RGCs exhibit morphological characteristics typical of alpha RGCs and physiological response properties of Y-cells. Melanopsin was not detected in these RGCs and they show no evidence of intrinsic photosensitivity.

Conclusions/Significance: These findings suggest that RGCs with alpha-like morphology and Y-like physiology appear to perform a non-imaging forming function and thus may participate in the modulation of DRN activity which includes regulation of sleep and mood.

语种英语
WOS记录号WOS:000290020700008
项目编号30831160516 ; 2011CB510206 ; 2009CB320900 ; R01 EY017809 ; N_HKU750/08 ; 21609101 ; 2011CB707501
资助机构National Science Foundation of China ; Ministry of Science and Technology of China ; National Institutes of Health, USA ; NSFC/RGC ; Fundamental Research Funds for the Central Universities ; National Basic Research Program of China (973 Program)
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61702
专题北京大学基础医学院_解剖学与组织胚胎学系
北京大学基础医学院
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Anat, Beijing 100871, Peoples R China
2.Peking Univ, Key Lab Machine Percept, Beijing 100871, Peoples R China
3.Peking Univ, Key Lab Visual Impairment & Restore, Beijing 100871, Peoples R China
4.Univ Hong Kong, Dept Anat, LKS Fac Med, Res Ctr Heart Brain Hormone & Hlth Aging, Pokfulam, Hong Kong, Peoples R China
5.Univ Hong Kong, State Key Lab Brain & Cognit Sci, Pokfulam, Hong Kong, Peoples R China
6.Univ Nebraska Lincoln, Sch Vet Med & Biomed Sci, Lincoln, NE USA
7.Jinan Univ, Joint Lab Brain Funct & Hlth, Guangzhou, Guangdong, Peoples R China
8.Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China
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Luan, Liju,Ren, Chaoran,Lau, Benson Wui-Man,et al. Y-Like Retinal Ganglion Cells Innervate the Dorsal Raphe Nucleus in the Mongolian Gerbil (Meriones unguiculatus)[J]. PLOS ONE,2011,6(4).
APA Luan, Liju.,Ren, Chaoran.,Lau, Benson Wui-Man.,Yang, Jian.,Pickard, Gary E..,...&Pu, Mingliang.(2011).Y-Like Retinal Ganglion Cells Innervate the Dorsal Raphe Nucleus in the Mongolian Gerbil (Meriones unguiculatus).PLOS ONE,6(4).
MLA Luan, Liju,et al."Y-Like Retinal Ganglion Cells Innervate the Dorsal Raphe Nucleus in the Mongolian Gerbil (Meriones unguiculatus)".PLOS ONE 6.4(2011).
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