IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Symptom improvement after helicobacter pylori eradication in patients with functional dyspepsia-A multicenter, randomized, prospective cohort study
Xu, Sanping1; Wan, Xueming1; Zheng, Xiaolan1; Zhou, Yali2; Song, Zhiqiang2; Cheng, Minghu3; Du, Yiqi4; Hou, Xiaohua1
关键词Epigastric pain syndrome functional dyspepsia helicobacter pylori eradication helicobacter pylori infection postprandial distress syndrome sequential-therapy triple-therapy
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2013
6期:9页:747-756
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
资助者National Science and Technology Program ; National Science and Technology Program
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]NONULCER DYSPEPSIA ; INFECTION ; GASTRITIS
英文摘要

Objective: To observe the improvement of functional dyspepsia (FD) after helicobacter pylori (HP) eradication in FD patients. Methods: 644 FD patients were recruited of whom 585 completed follow up. They were divided into postprandial distress syndrome (PDS) group and epigastric pain syndrome (EPS) group. Patients with HP infection were randomly allocated into eradication group and non-eradication group. Patients in the eradication group were randomly assigned into two groups and treated with triple therapy and sequential therapy, respectively. Patients in non-eradication group and HP non-infection group were treated with Domperidone (PDS patients) or Talcid (EPS patients). Clinical symptoms were evaluated. Results: When compared with patients with unsuccessful HP eradication and without eradication, significant improvement in symptoms was found at 8 w, 12 w, and 26 w in patients with successful HP eradication in EPS group (P < 0.05). However, in PDS group, improvement in symptoms was comparable among patients expect at 26 w after successful HP eradication (P < 0.05). Therapeutic efficacy in patients without HP eradication was poorer than that in HP negative patients in EPS group (P < 0.05), while in PDS group, symptoms were relived at 26 w and 52 w (P < 0.05). Conclusions: HP is one of pathogenic factors of FD and HP eradication may benefit FD patients, regardless therapeutic regimes, especially in EPS patients.

语种英语
所属项目编号2007BAI04B02
资助者National Science and Technology Program ; National Science and Technology Program
WOS记录号WOS:000327587600003
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61705
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Beijing, Peoples R China
2.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Div Gastroenterol, Wuhan 430074, Peoples R China
3.Zhongshan Univ, ZhongShan Hosp, Guangzhou, Guangdong, Peoples R China
4.Second Mil Med Univ, ChangHai Hosp, Shanghai, Peoples R China
推荐引用方式
GB/T 7714
Xu, Sanping,Wan, Xueming,Zheng, Xiaolan,et al. Symptom improvement after helicobacter pylori eradication in patients with functional dyspepsia-A multicenter, randomized, prospective cohort study[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2013,6(9):747-756.
APA Xu, Sanping.,Wan, Xueming.,Zheng, Xiaolan.,Zhou, Yali.,Song, Zhiqiang.,...&Hou, Xiaohua.(2013).Symptom improvement after helicobacter pylori eradication in patients with functional dyspepsia-A multicenter, randomized, prospective cohort study.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,6(9),747-756.
MLA Xu, Sanping,et al."Symptom improvement after helicobacter pylori eradication in patients with functional dyspepsia-A multicenter, randomized, prospective cohort study".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 6.9(2013):747-756.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xu, Sanping]的文章
[Wan, Xueming]的文章
[Zheng, Xiaolan]的文章
百度学术
百度学术中相似的文章
[Xu, Sanping]的文章
[Wan, Xueming]的文章
[Zheng, Xiaolan]的文章
必应学术
必应学术中相似的文章
[Xu, Sanping]的文章
[Wan, Xueming]的文章
[Zheng, Xiaolan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。