IR@PKUHSC  > 北京大学临床肿瘤学院  > 遗传学研究室
学科主题临床医学
Genetic polymorphisms of NAMPT related with susceptibility to esophageal Squamous cell carcinoma
Zhang, Chuanzhen1; Yan, Daojie2; Wang, Shanshan1; Xu, Changqing1; Du, Wenjun1; Ning, Tao3; Liu, Changhong1; Zhang, Meijuan1; Hou, Ruiping1; Chen, Ziping1
关键词Nicotinamide phosphoribosyl transferase Polymorphism Haplotype Esophageal squamous cell carcinoma Susceptibility
刊名BMC GASTROENTEROLOGY
2015-04-21
DOI10.1186/s12876-015-0282-6
15
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
资助者Program of Shandong Province&prime ; s Pharmaceutical Health and Technology Development ; Program of Shandong Province&prime ; s Pharmaceutical Health and Technology Development
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]CANCER ; VISFATIN
英文摘要

Background: Nicotinamide phosphoribosyl transferase (Nampt) plays a crucial role in tumorigenesis. The present study examines whether genetic polymorphisms of NAMPT are related to the risk of developing esophageal squamous cell carcinoma (ESCC).

Methods: A total of 810 subjects were enrolled in this study, including 405 ESCC patients and 405 healthy controls. Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), genotypes at rs61330082, rs2505568 and rs9034 of NAMPT were identified. Haplotypes were constructed using PHASE software. Multivariate logistic regression models were used to evaluate the potentiating effects of the genotypes, alleles and haplotypes on the development of ESCC.

Results: The presence of genotypes CT and TT and allele T at rs61330082 was less frequent in ESCC cases than in controls (48.89% vs. 53.33%, P < 0.01, 95% CI: 0.33-0.68; 18.52% vs. 30.37%, P < 0.01, 95% CI: 0.22-0.50; 42.96% vs. 57.04%, P < 0.01, 95% CI: 0.38-0.61; respectively). No statistically significant differences existed in the distributions of genotypes or alleles at rs2505568 or rs9034 between ESCC cases and controls. Of five haplotypes constructed, haplotypes CTC, CTT and CAC were higher in ESCC cases (P < 0.01, OR = 1.57, 95% CI: 1.16-2.12; P = 0.04, OR = 1.72, 95% CI: 1.03-2.85; P < 0.01, OR = 3.39, 95% CI: 1.99-5.75; respectively) than in controls.

Conclusion: Genetic polymorphisms of NAMPT, specifically genotype CC and allele C at rs61330082 as well as haplotypes CTC, CTT and CAC, were significantly correlated with ESCC susceptibility.

语种英语
所属项目编号HZ068
资助者Program of Shandong Province&prime ; s Pharmaceutical Health and Technology Development ; Program of Shandong Province&prime ; s Pharmaceutical Health and Technology Development
WOS记录号WOS:000353438400001
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61709
专题北京大学临床肿瘤学院_遗传学研究室
作者单位1.Shandong Univ, Shandong Prov Qianfoshan Hosp, Digest Dept, Jinan 250014, Peoples R China
2.Laiwu Hosp, Taishan Med Coll, Infect Dis Hosp, Laiwu, Peoples R China
3.Peking Univ, Genet Lab, Key Lab Carcinogenesis & Translat Res, Beijing Canc Hosp & Inst,Sch Oncol,Minist Educ, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Chuanzhen,Yan, Daojie,Wang, Shanshan,et al. Genetic polymorphisms of NAMPT related with susceptibility to esophageal Squamous cell carcinoma[J]. BMC GASTROENTEROLOGY,2015,15.
APA Zhang, Chuanzhen.,Yan, Daojie.,Wang, Shanshan.,Xu, Changqing.,Du, Wenjun.,...&Chen, Ziping.(2015).Genetic polymorphisms of NAMPT related with susceptibility to esophageal Squamous cell carcinoma.BMC GASTROENTEROLOGY,15.
MLA Zhang, Chuanzhen,et al."Genetic polymorphisms of NAMPT related with susceptibility to esophageal Squamous cell carcinoma".BMC GASTROENTEROLOGY 15(2015).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Chuanzhen]的文章
[Yan, Daojie]的文章
[Wang, Shanshan]的文章
百度学术
百度学术中相似的文章
[Zhang, Chuanzhen]的文章
[Yan, Daojie]的文章
[Wang, Shanshan]的文章
必应学术
必应学术中相似的文章
[Zhang, Chuanzhen]的文章
[Yan, Daojie]的文章
[Wang, Shanshan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。