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学科主题: 临床医学
题名:
Genetic polymorphisms of NAMPT related with susceptibility to esophageal Squamous cell carcinoma
作者: Zhang, Chuanzhen1; Yan, Daojie2; Wang, Shanshan1; Xu, Changqing1; Du, Wenjun1; Ning, Tao3; Liu, Changhong1; Zhang, Meijuan1; Hou, Ruiping1; Chen, Ziping1
关键词: Nicotinamide phosphoribosyl transferase ; Polymorphism ; Haplotype ; Esophageal squamous cell carcinoma ; Susceptibility
刊名: BMC GASTROENTEROLOGY
发表日期: 2015-04-21
DOI: 10.1186/s12876-015-0282-6
卷: 15
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: CANCER ; VISFATIN
英文摘要:

Background: Nicotinamide phosphoribosyl transferase (Nampt) plays a crucial role in tumorigenesis. The present study examines whether genetic polymorphisms of NAMPT are related to the risk of developing esophageal squamous cell carcinoma (ESCC).

Methods: A total of 810 subjects were enrolled in this study, including 405 ESCC patients and 405 healthy controls. Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), genotypes at rs61330082, rs2505568 and rs9034 of NAMPT were identified. Haplotypes were constructed using PHASE software. Multivariate logistic regression models were used to evaluate the potentiating effects of the genotypes, alleles and haplotypes on the development of ESCC.

Results: The presence of genotypes CT and TT and allele T at rs61330082 was less frequent in ESCC cases than in controls (48.89% vs. 53.33%, P < 0.01, 95% CI: 0.33-0.68; 18.52% vs. 30.37%, P < 0.01, 95% CI: 0.22-0.50; 42.96% vs. 57.04%, P < 0.01, 95% CI: 0.38-0.61; respectively). No statistically significant differences existed in the distributions of genotypes or alleles at rs2505568 or rs9034 between ESCC cases and controls. Of five haplotypes constructed, haplotypes CTC, CTT and CAC were higher in ESCC cases (P < 0.01, OR = 1.57, 95% CI: 1.16-2.12; P = 0.04, OR = 1.72, 95% CI: 1.03-2.85; P < 0.01, OR = 3.39, 95% CI: 1.99-5.75; respectively) than in controls.

Conclusion: Genetic polymorphisms of NAMPT, specifically genotype CC and allele C at rs61330082 as well as haplotypes CTC, CTT and CAC, were significantly correlated with ESCC susceptibility.

语种: 英语
所属项目编号: HZ068
项目资助者: Program of Shandong Province&prime ; s Pharmaceutical Health and Technology Development
WOS记录号: WOS:000353438400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61709
Appears in Collections:北京大学临床肿瘤学院_遗传学研究室_期刊论文

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作者单位: 1.Shandong Univ, Shandong Prov Qianfoshan Hosp, Digest Dept, Jinan 250014, Peoples R China
2.Laiwu Hosp, Taishan Med Coll, Infect Dis Hosp, Laiwu, Peoples R China
3.Peking Univ, Genet Lab, Key Lab Carcinogenesis & Translat Res, Beijing Canc Hosp & Inst,Sch Oncol,Minist Educ, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Chuanzhen,Yan, Daojie,Wang, Shanshan,et al. Genetic polymorphisms of NAMPT related with susceptibility to esophageal Squamous cell carcinoma[J]. BMC GASTROENTEROLOGY,2015,15.
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