|Genetic polymorphisms of NAMPT related with susceptibility to esophageal Squamous cell carcinoma|
|Zhang, Chuanzhen1; Yan, Daojie2; Wang, Shanshan1; Xu, Changqing1; Du, Wenjun1; Ning, Tao3; Liu, Changhong1; Zhang, Meijuan1; Hou, Ruiping1; Chen, Ziping1|
|关键词||Nicotinamide phosphoribosyl transferase Polymorphism Haplotype Esophageal squamous cell carcinoma Susceptibility|
|WOS标题词||Science & Technology|
|类目[WOS]||Gastroenterology & Hepatology|
|研究领域[WOS]||Gastroenterology & Hepatology|
|关键词[WOS]||CANCER ; VISFATIN|
Background: Nicotinamide phosphoribosyl transferase (Nampt) plays a crucial role in tumorigenesis. The present study examines whether genetic polymorphisms of NAMPT are related to the risk of developing esophageal squamous cell carcinoma (ESCC).
Methods: A total of 810 subjects were enrolled in this study, including 405 ESCC patients and 405 healthy controls. Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), genotypes at rs61330082, rs2505568 and rs9034 of NAMPT were identified. Haplotypes were constructed using PHASE software. Multivariate logistic regression models were used to evaluate the potentiating effects of the genotypes, alleles and haplotypes on the development of ESCC.
Results: The presence of genotypes CT and TT and allele T at rs61330082 was less frequent in ESCC cases than in controls (48.89% vs. 53.33%, P < 0.01, 95% CI: 0.33-0.68; 18.52% vs. 30.37%, P < 0.01, 95% CI: 0.22-0.50; 42.96% vs. 57.04%, P < 0.01, 95% CI: 0.38-0.61; respectively). No statistically significant differences existed in the distributions of genotypes or alleles at rs2505568 or rs9034 between ESCC cases and controls. Of five haplotypes constructed, haplotypes CTC, CTT and CAC were higher in ESCC cases (P < 0.01, OR = 1.57, 95% CI: 1.16-2.12; P = 0.04, OR = 1.72, 95% CI: 1.03-2.85; P < 0.01, OR = 3.39, 95% CI: 1.99-5.75; respectively) than in controls.
Conclusion: Genetic polymorphisms of NAMPT, specifically genotype CC and allele C at rs61330082 as well as haplotypes CTC, CTT and CAC, were significantly correlated with ESCC susceptibility.
|资助机构||Program of Shandong Province&prime ; s Pharmaceutical Health and Technology Development|
|作者单位||1.Shandong Univ, Shandong Prov Qianfoshan Hosp, Digest Dept, Jinan 250014, Peoples R China|
2.Laiwu Hosp, Taishan Med Coll, Infect Dis Hosp, Laiwu, Peoples R China
3.Peking Univ, Genet Lab, Key Lab Carcinogenesis & Translat Res, Beijing Canc Hosp & Inst,Sch Oncol,Minist Educ, Beijing 100871, Peoples R China
|Zhang, Chuanzhen,Yan, Daojie,Wang, Shanshan,et al. Genetic polymorphisms of NAMPT related with susceptibility to esophageal Squamous cell carcinoma[J]. BMC GASTROENTEROLOGY,2015,15.|
|APA||Zhang, Chuanzhen.,Yan, Daojie.,Wang, Shanshan.,Xu, Changqing.,Du, Wenjun.,...&Chen, Ziping.(2015).Genetic polymorphisms of NAMPT related with susceptibility to esophageal Squamous cell carcinoma.BMC GASTROENTEROLOGY,15.|
|MLA||Zhang, Chuanzhen,et al."Genetic polymorphisms of NAMPT related with susceptibility to esophageal Squamous cell carcinoma".BMC GASTROENTEROLOGY 15(2015).|