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学科主题: 临床医学
题名:
Retinal arterial abnormalities correlate with brain white matter lesions in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy
作者: Liu, Yang; Wu, Yuan2; Xie, Sheng3; Luan, Xing-hua; Yuan, Yun1
关键词: CADASIL ; magnetic resonance imaging ; retinal vessel
刊名: CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
发表日期: 2008-08-01
DOI: 10.1111/j.1442-9071.2008.01825.x
卷: 36, 期:6, 页:532-536
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: SMALL VESSEL DISEASE ; MICROVASCULAR ABNORMALITIES ; ATHEROSCLEROSIS RISK ; CADASIL ; COMMUNITIES ; STROKE
英文摘要:

Purpose: The aim of this study is to determine the relationship between retinal abnormalities and brain white matter hyper-intensities (WMH) in symptomatic patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL).

Methods: Fifteen patients with CADASIL and fifteen age-matched healthy control individuals were enrolled in this study. Ophthalmological examinations were performed on all subjects and all patients with CADASIL underwent cerebral MRI scanning. Retinal artery abnormalities were graded according to the Keith-Wagener-Barker hypertensive retinopathy classification. WMH were classified as punctuate (Grade 1), nodular or early confluent (Grade 2) and diffusly confluent (Grade 3). Partial correlation was used to assess the relationship between retinal abnormalities and WMH, controlling for age.

Results: Retinal arteriole narrowing existed in 15 cases and 2 controls, with Grade 2 and Grade 3 being the most common grading of retinal artery narrowing in patients with CADASIL. All patients had WMH on MRI, rated as Grade 1 in one patient, Grade 2 in five patients and Grade 3 in nine patients. The correlation coefficient of retinal arteriole narrowing and WMH was 0.546 (P < 0.05).

Conclusion: Retinal arteriole narrowing may be associated with the severity of the cerebral lesions in CADASIL.

语种: 英语
所属项目编号: 30470595 ; 7052042
项目资助者: National Natural Science Foundation ; Beijing Natural Science foundation
WOS记录号: WOS:000260009000008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61722
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Neurol, Lab Neuropathol & Mol Biol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Ophthalmol, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China

Recommended Citation:
Liu, Yang,Wu, Yuan,Xie, Sheng,et al. Retinal arterial abnormalities correlate with brain white matter lesions in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy[J]. CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,2008,36(6):532-536.
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