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Retinal arterial abnormalities correlate with brain white matter lesions in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy
Liu, Yang; Wu, Yuan2; Xie, Sheng3; Luan, Xing-hua; Yuan, Yun1
关键词CADASIL magnetic resonance imaging retinal vessel
刊名CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
2008-08-01
DOI10.1111/j.1442-9071.2008.01825.x
36期:6页:532-536
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]SMALL VESSEL DISEASE ; MICROVASCULAR ABNORMALITIES ; ATHEROSCLEROSIS RISK ; CADASIL ; COMMUNITIES ; STROKE
英文摘要

Purpose: The aim of this study is to determine the relationship between retinal abnormalities and brain white matter hyper-intensities (WMH) in symptomatic patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL).

Methods: Fifteen patients with CADASIL and fifteen age-matched healthy control individuals were enrolled in this study. Ophthalmological examinations were performed on all subjects and all patients with CADASIL underwent cerebral MRI scanning. Retinal artery abnormalities were graded according to the Keith-Wagener-Barker hypertensive retinopathy classification. WMH were classified as punctuate (Grade 1), nodular or early confluent (Grade 2) and diffusly confluent (Grade 3). Partial correlation was used to assess the relationship between retinal abnormalities and WMH, controlling for age.

Results: Retinal arteriole narrowing existed in 15 cases and 2 controls, with Grade 2 and Grade 3 being the most common grading of retinal artery narrowing in patients with CADASIL. All patients had WMH on MRI, rated as Grade 1 in one patient, Grade 2 in five patients and Grade 3 in nine patients. The correlation coefficient of retinal arteriole narrowing and WMH was 0.546 (P < 0.05).

Conclusion: Retinal arteriole narrowing may be associated with the severity of the cerebral lesions in CADASIL.

语种英语
WOS记录号WOS:000260009000008
项目编号30470595 ; 7052042
资助机构National Natural Science Foundation ; Beijing Natural Science foundation
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61722
专题北京大学第一临床医学院_神经内科
作者单位1.Peking Univ, Hosp 1, Dept Neurol, Lab Neuropathol & Mol Biol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Ophthalmol, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China
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GB/T 7714
Liu, Yang,Wu, Yuan,Xie, Sheng,et al. Retinal arterial abnormalities correlate with brain white matter lesions in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy[J]. CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,2008,36(6):532-536.
APA Liu, Yang,Wu, Yuan,Xie, Sheng,Luan, Xing-hua,&Yuan, Yun.(2008).Retinal arterial abnormalities correlate with brain white matter lesions in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy.CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,36(6),532-536.
MLA Liu, Yang,et al."Retinal arterial abnormalities correlate with brain white matter lesions in cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy".CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 36.6(2008):532-536.
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