|Ocular fundus pathology and chronic kidney disease in a Chinese population|
|Gao, Bixia1,2,3; Zhu, Ling4; Pan, Yingzi5; Yang, Shuwen4; Zhang, Luxia1,2,3; Wang, Haiyan1,2,3|
|WOS标题词||Science & Technology|
|类目[WOS]||Urology & Nephrology|
|研究领域[WOS]||Urology & Nephrology|
|关键词[WOS]||RETINAL MICROVASCULAR ABNORMALITIES ; GLOMERULAR-FILTRATION-RATE ; MACULAR DEGENERATION ; VISUAL IMPAIRMENT ; ADULTS ; RISK ; ASSOCIATIONS ; STROKE ; EYE|
Background: Previous study indicated a high prevalence of ocular fundus pathology among patients with chronic kidney disease (CKD), while the relationship between them has never been explored in a Chinese Population.
Methods: This cross-sectional study included 9 670 participants enrolled in a medical screening program. Ocular fundus examination was performed by ophthalmologists using ophthalmoscopes. The presence of eGFR less than 60 mL/min/1.73 m(2) and/or proteinuria was defined as CKD.
Results: Compared to participants without CKD, participants with CKD had higher prevalence of retinopathy (28.5% vs. 16.3%, P < 0.001), glaucoma suspect (3.1% vs. 1.8%, P = 0.004), age-related macular degeneration (1.7% vs. 0.9%, P = 0.01) and overall eye pathology (32.0% vs. 19.4%, P < 0.001). After adjusting for potential confounders, the odds ratio of proteinuria for overall eye pathology and retinopathy was 1.29 (95% confidence interval [CI] 1.07-1.55) and 1.37 (95% CI 1.12-1.67), respectively. The results were robust after excluding participants with hypertension or with diabetes.
Conclusions: Ocular fundus pathology is common among Chinese patients with CKD. Regular eye exam among persons with proteinuria is warranted.
|项目编号||BMU2009131 ; 2006B05|
|资助机构||China Health and Medical Development Foundation ; Ministry of Education of the People&prime ; s Republic of China ; Beijing Municipal Science and Technology Commission|
|作者单位||1.Beijing Hosp, Phys Examinat Ctr, Beijing, Peoples R China|
2.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing, Peoples R China
3.Peking Univ, Inst Nephrol, Key Lab Renal Dis, Minist Hlth China, Beijing, Peoples R China
4.Peking Univ, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing, Peoples R China
5.Peking Univ, Hosp 1, Div Ophthalmol, Beijing 100871, Peoples R China
|Gao, Bixia,Zhu, Ling,Pan, Yingzi,et al. Ocular fundus pathology and chronic kidney disease in a Chinese population[J]. BMC NEPHROLOGY,2011,12.|
|APA||Gao, Bixia,Zhu, Ling,Pan, Yingzi,Yang, Shuwen,Zhang, Luxia,&Wang, Haiyan.(2011).Ocular fundus pathology and chronic kidney disease in a Chinese population.BMC NEPHROLOGY,12.|
|MLA||Gao, Bixia,et al."Ocular fundus pathology and chronic kidney disease in a Chinese population".BMC NEPHROLOGY 12(2011).|