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学科主题: 临床医学
题名:
Ocular fundus pathology and chronic kidney disease in a Chinese population
作者: Gao, Bixia1,2,3; Zhu, Ling4; Pan, Yingzi5; Yang, Shuwen4; Zhang, Luxia1,2,3; Wang, Haiyan1,2,3
刊名: BMC NEPHROLOGY
发表日期: 2011-11-17
DOI: 10.1186/1471-2369-12-62
卷: 12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: RETINAL MICROVASCULAR ABNORMALITIES ; GLOMERULAR-FILTRATION-RATE ; MACULAR DEGENERATION ; VISUAL IMPAIRMENT ; ADULTS ; RISK ; ASSOCIATIONS ; STROKE ; EYE
英文摘要:

Background: Previous study indicated a high prevalence of ocular fundus pathology among patients with chronic kidney disease (CKD), while the relationship between them has never been explored in a Chinese Population.

Methods: This cross-sectional study included 9 670 participants enrolled in a medical screening program. Ocular fundus examination was performed by ophthalmologists using ophthalmoscopes. The presence of eGFR less than 60 mL/min/1.73 m(2) and/or proteinuria was defined as CKD.

Results: Compared to participants without CKD, participants with CKD had higher prevalence of retinopathy (28.5% vs. 16.3%, P < 0.001), glaucoma suspect (3.1% vs. 1.8%, P = 0.004), age-related macular degeneration (1.7% vs. 0.9%, P = 0.01) and overall eye pathology (32.0% vs. 19.4%, P < 0.001). After adjusting for potential confounders, the odds ratio of proteinuria for overall eye pathology and retinopathy was 1.29 (95% confidence interval [CI] 1.07-1.55) and 1.37 (95% CI 1.12-1.67), respectively. The results were robust after excluding participants with hypertension or with diabetes.

Conclusions: Ocular fundus pathology is common among Chinese patients with CKD. Regular eye exam among persons with proteinuria is warranted.

语种: 英语
所属项目编号: BMU2009131 ; 2006B05
项目资助者: China Health and Medical Development Foundation ; Ministry of Education of the People&prime ; s Republic of China ; Beijing Municipal Science and Technology Commission
WOS记录号: WOS:000304369500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61726
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Beijing Hosp, Phys Examinat Ctr, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing, Peoples R China
3.Peking Univ, Inst Nephrol, Key Lab Renal Dis, Minist Hlth China, Beijing, Peoples R China
4.Peking Univ, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing, Peoples R China
5.Peking Univ, Hosp 1, Div Ophthalmol, Beijing 100871, Peoples R China

Recommended Citation:
Gao, Bixia,Zhu, Ling,Pan, Yingzi,et al. Ocular fundus pathology and chronic kidney disease in a Chinese population[J]. BMC NEPHROLOGY,2011,12.
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