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学科主题: 临床医学
题名:
Genotyping of HLA-I and HLA-II alleles in Chinese patients with paraneoplastic pemphigus
作者: Liu, Q.; Bu, D-F.; Li, D.1; Zhu, X-J.
关键词: bullous skin diseases ; HLA ; immunogenetic susceptibility ; paraneoplastic pemphigus
刊名: BRITISH JOURNAL OF DERMATOLOGY
发表日期: 2008-03-01
DOI: 10.1111/j.1365-2133.2007.08361.x
卷: 158, 期:3, 页:587-591
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology
研究领域[WOS]: Dermatology
关键词[WOS]: VULGARIS ; AUTOANTIBODIES ; SUSCEPTIBILITY ; AUTOIMMUNITY ; MOLECULES ; FOLIACEUS ; PEPTIDES
英文摘要:

Background Class I and class II HLA genes are thought to play a role in the immunopathogenesis of bullous dermatoses such as pemphigus vulgaris and pemphigus foliaceus, but we know little about the genetic background of paraneoplastic pemphigus (PNP) in Chinese patients.

Objectives To identify class I and class II HLA alleles by genotyping in Chinese patients with PNP, and to find out the possible association between HLA alleles and disease susceptibility.

Methods Nineteen Chinese patients with PNP were enrolled in this study. HLA-A, B, C, DRB1 and DQB1 alleles were typed by polymerase chain reaction and a colour-coded sequence-specific oligonucleotide probes method.

Results The frequencies of HLA-B*4002/B*4004, B*51, B*52, Cw*14, DQB1*0301, DRB1*08 and DRB1*11 were relatively prevalent in Chinese Han patients with PNP in comparison with normal controls. After correction for multiple comparisons, Cw*14 remained statistically significant, and the other alleles were unremarkable in these patients.

Conclusions The genetic background predisposing to PNP may be different in patients from various races and areas. HLA-Cw*14 may be the predisposing allele to PNP in Chinese patients, which is different from the predisposing allele in French patients with PNP and the alleles predisposing to pemphigus vulgaris and pemphigus foliaceus.

语种: 英语
WOS记录号: WOS:000253120700023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61727
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Inst Hematol, HLA Lab, Beijing 100044, Peoples R China
2.Peking Univ, First Hosp, Dept Dermatol, Beijing 100044, Peoples R China

Recommended Citation:
Liu, Q.,Bu, D-F.,Li, D.,et al. Genotyping of HLA-I and HLA-II alleles in Chinese patients with paraneoplastic pemphigus[J]. BRITISH JOURNAL OF DERMATOLOGY,2008,158(3):587-591.
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