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Genotyping of HLA-I and HLA-II alleles in Chinese patients with paraneoplastic pemphigus
Liu, Q.; Bu, D-F.; Li, D.1; Zhu, X-J.
关键词bullous skin diseases HLA immunogenetic susceptibility paraneoplastic pemphigus
刊名BRITISH JOURNAL OF DERMATOLOGY
2008-03-01
DOI10.1111/j.1365-2133.2007.08361.x
158期:3页:587-591
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology
研究领域[WOS]Dermatology
关键词[WOS]VULGARIS ; AUTOANTIBODIES ; SUSCEPTIBILITY ; AUTOIMMUNITY ; MOLECULES ; FOLIACEUS ; PEPTIDES
英文摘要

Background Class I and class II HLA genes are thought to play a role in the immunopathogenesis of bullous dermatoses such as pemphigus vulgaris and pemphigus foliaceus, but we know little about the genetic background of paraneoplastic pemphigus (PNP) in Chinese patients.

Objectives To identify class I and class II HLA alleles by genotyping in Chinese patients with PNP, and to find out the possible association between HLA alleles and disease susceptibility.

Methods Nineteen Chinese patients with PNP were enrolled in this study. HLA-A, B, C, DRB1 and DQB1 alleles were typed by polymerase chain reaction and a colour-coded sequence-specific oligonucleotide probes method.

Results The frequencies of HLA-B*4002/B*4004, B*51, B*52, Cw*14, DQB1*0301, DRB1*08 and DRB1*11 were relatively prevalent in Chinese Han patients with PNP in comparison with normal controls. After correction for multiple comparisons, Cw*14 remained statistically significant, and the other alleles were unremarkable in these patients.

Conclusions The genetic background predisposing to PNP may be different in patients from various races and areas. HLA-Cw*14 may be the predisposing allele to PNP in Chinese patients, which is different from the predisposing allele in French patients with PNP and the alleles predisposing to pemphigus vulgaris and pemphigus foliaceus.

语种英语
WOS记录号WOS:000253120700023
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61727
专题北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Peoples Hosp, Inst Hematol, HLA Lab, Beijing 100044, Peoples R China
2.Peking Univ, First Hosp, Dept Dermatol, Beijing 100044, Peoples R China
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GB/T 7714
Liu, Q.,Bu, D-F.,Li, D.,et al. Genotyping of HLA-I and HLA-II alleles in Chinese patients with paraneoplastic pemphigus[J]. BRITISH JOURNAL OF DERMATOLOGY,2008,158(3):587-591.
APA Liu, Q.,Bu, D-F.,Li, D.,&Zhu, X-J..(2008).Genotyping of HLA-I and HLA-II alleles in Chinese patients with paraneoplastic pemphigus.BRITISH JOURNAL OF DERMATOLOGY,158(3),587-591.
MLA Liu, Q.,et al."Genotyping of HLA-I and HLA-II alleles in Chinese patients with paraneoplastic pemphigus".BRITISH JOURNAL OF DERMATOLOGY 158.3(2008):587-591.
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