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学科主题基础医学
Nested genes in the human genome
Yu, P; Ma, DL; Xu, MX
关键词nested gene gene-within-a-gene overlapping gene evolution comparative analysis inverse expression
刊名GENOMICS
2005-10-01
DOI10.1016/j.ygeno.2005.06.008
86期:4页:414-422
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity
研究领域[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity
关键词[WOS]ANTISENSE TRANSCRIPTS ; OVERLAPPING GENES ; DNA-SEQUENCE ; DATABASE ; ONTOLOGY ; SENSE ; CORNEODESMOSIN ; EUKARYOTES ; EXPRESSION ; PROTEINS
英文摘要

Here we studied one special type of gene, i.e., the nested gene, in the human genome. We collected 373 reliably annotated nested genes. Two-thirds of them were on the strand opposite that of their host gene. About 58% coding nested gene pairs were conserved in mouse and some were even maintained in chicken and fish, while nested pseudogenes were poorly conserved. K-a/K-s analysis revealed that nested genes were under strong selection, although they did not demonstrate greater conservation than other genes. With microarray data we observed that two partners of one nested pair seemed to be expressed reciprocally. A significant proportion of nested genes were tissue-specifically expressed. Gene ontology analysis demonstrated that quite a number of nested genes participated in cellular signal transduction. Based on these observations, we think that nested genes are a group of genes with important physiological functions. (C) 2005 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000232122400004
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被引频次:43[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
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条目标识符http://ir.bjmu.edu.cn/handle/400002259/61730
专题北京大学基础医学院_免疫学系
作者单位1.Peking Univ, Sch Basic Med Sci, Lab Med Immunol, Beijing 100083, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
3.Peking Univ, Ctr Bioinformat, Beijing 100083, Peoples R China
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Yu, P,Ma, DL,Xu, MX. Nested genes in the human genome[J]. GENOMICS,2005,86(4):414-422.
APA Yu, P,Ma, DL,&Xu, MX.(2005).Nested genes in the human genome.GENOMICS,86(4),414-422.
MLA Yu, P,et al."Nested genes in the human genome".GENOMICS 86.4(2005):414-422.
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