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学科主题: 基础医学
题名:
Nested genes in the human genome
作者: Yu, P; Ma, DL; Xu, MX
关键词: nested gene ; gene-within-a-gene ; overlapping gene ; evolution ; comparative analysis ; inverse expression
刊名: GENOMICS
发表日期: 2005-10-01
DOI: 10.1016/j.ygeno.2005.06.008
卷: 86, 期:4, 页:414-422
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Genetics & Heredity
研究领域[WOS]: Biotechnology & Applied Microbiology ; Genetics & Heredity
关键词[WOS]: ANTISENSE TRANSCRIPTS ; OVERLAPPING GENES ; DNA-SEQUENCE ; DATABASE ; ONTOLOGY ; SENSE ; CORNEODESMOSIN ; EUKARYOTES ; EXPRESSION ; PROTEINS
英文摘要:

Here we studied one special type of gene, i.e., the nested gene, in the human genome. We collected 373 reliably annotated nested genes. Two-thirds of them were on the strand opposite that of their host gene. About 58% coding nested gene pairs were conserved in mouse and some were even maintained in chicken and fish, while nested pseudogenes were poorly conserved. K-a/K-s analysis revealed that nested genes were under strong selection, although they did not demonstrate greater conservation than other genes. With microarray data we observed that two partners of one nested pair seemed to be expressed reciprocally. A significant proportion of nested genes were tissue-specifically expressed. Gene ontology analysis demonstrated that quite a number of nested genes participated in cellular signal transduction. Based on these observations, we think that nested genes are a group of genes with important physiological functions. (C) 2005 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000232122400004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61730
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Lab Med Immunol, Beijing 100083, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
3.Peking Univ, Ctr Bioinformat, Beijing 100083, Peoples R China

Recommended Citation:
Yu, P,Ma, DL,Xu, MX. Nested genes in the human genome[J]. GENOMICS,2005,86(4):414-422.
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