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Drug-induced alterations in the extracellular signal-regulated kinase (ERK) signalling pathway: Implications for reinforcement and reinstatement
Zhai, Haifeng; Li, Yanqin; Wang, Xi; Lu, Lin
关键词addiction neuroplasticity reward relapse dopamine glutamate contextual cues
刊名CELLULAR AND MOLECULAR NEUROBIOLOGY
2008-02-01
DOI10.1007/s10571-007-9240-3
28期:2页:157-172
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Neurosciences
研究领域[WOS]Cell Biology ; Neurosciences & Neurology
关键词[WOS]ACTIVATED PROTEIN-KINASE ; VENTRAL TEGMENTAL AREA ; ETHANOL-MEDIATED INHIBITION ; ELEMENT-BINDING PROTEIN ; LONG-TERM POTENTIATION ; GENE-EXPRESSION ; IN-VIVO ; NUCLEUS-ACCUMBENS ; CENTRAL AMYGDALA ; COCAINE-SEEKING
英文摘要

Drug addiction, characterized by high rates of relapse, is recognized as a kind of neuroadaptive disorder. Since the extracellular signal-regulated kinase (ERK) pathway is critical to neuroplasticity in the adult brain, understanding the role this pathway plays is important for understanding the molecular mechanism underlying drug addiction and relapse. Here, we review previous literatures that focus on the effects of exposure to cocaine, amphetamine, Delta(9)-tetrahydrocannabinol (THC), nicotine, morphine, and alcohol on ERK signaling in the mesocorticolimbic dopamine system; these alterations of ERK signaling have been thought to contribute to the drug′s rewarding effects and to the long-term maladaptation induced by drug abuse. We then discuss the possible upstreams of the ERK signaling pathway activated by exposure of drugs of abuse and the environmental cues previously paired with drugs. Finally, we argue that since ERK activation is a key molecular process in reinstatement of conditioned place preference and drug self-administration, the pharmacological manipulation of the ERK pathway is a potential treatment strategy for drug addiction.

语种英语
WOS记录号WOS:000253191900001
引用统计
被引频次:57[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61731
专题中国药物依赖性研究所
北京大学第三临床医学院_骨科
作者单位Peking Univ, Dept Neuropharmacol, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
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GB/T 7714
Zhai, Haifeng,Li, Yanqin,Wang, Xi,et al. Drug-induced alterations in the extracellular signal-regulated kinase (ERK) signalling pathway: Implications for reinforcement and reinstatement[J]. CELLULAR AND MOLECULAR NEUROBIOLOGY,2008,28(2):157-172.
APA Zhai, Haifeng,Li, Yanqin,Wang, Xi,&Lu, Lin.(2008).Drug-induced alterations in the extracellular signal-regulated kinase (ERK) signalling pathway: Implications for reinforcement and reinstatement.CELLULAR AND MOLECULAR NEUROBIOLOGY,28(2),157-172.
MLA Zhai, Haifeng,et al."Drug-induced alterations in the extracellular signal-regulated kinase (ERK) signalling pathway: Implications for reinforcement and reinstatement".CELLULAR AND MOLECULAR NEUROBIOLOGY 28.2(2008):157-172.
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