北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 中国药物依赖性研究所  > 期刊论文
学科主题: 药物依赖
题名:
Drug-induced alterations in the extracellular signal-regulated kinase (ERK) signalling pathway: Implications for reinforcement and reinstatement
作者: Zhai, Haifeng; Li, Yanqin; Wang, Xi; Lu, Lin
关键词: addiction ; neuroplasticity ; reward ; relapse ; dopamine ; glutamate ; contextual cues
刊名: CELLULAR AND MOLECULAR NEUROBIOLOGY
发表日期: 2008-02-01
DOI: 10.1007/s10571-007-9240-3
卷: 28, 期:2, 页:157-172
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Neurosciences
研究领域[WOS]: Cell Biology ; Neurosciences & Neurology
关键词[WOS]: ACTIVATED PROTEIN-KINASE ; VENTRAL TEGMENTAL AREA ; ETHANOL-MEDIATED INHIBITION ; ELEMENT-BINDING PROTEIN ; LONG-TERM POTENTIATION ; GENE-EXPRESSION ; IN-VIVO ; NUCLEUS-ACCUMBENS ; CENTRAL AMYGDALA ; COCAINE-SEEKING
英文摘要:

Drug addiction, characterized by high rates of relapse, is recognized as a kind of neuroadaptive disorder. Since the extracellular signal-regulated kinase (ERK) pathway is critical to neuroplasticity in the adult brain, understanding the role this pathway plays is important for understanding the molecular mechanism underlying drug addiction and relapse. Here, we review previous literatures that focus on the effects of exposure to cocaine, amphetamine, Delta(9)-tetrahydrocannabinol (THC), nicotine, morphine, and alcohol on ERK signaling in the mesocorticolimbic dopamine system; these alterations of ERK signaling have been thought to contribute to the drug′s rewarding effects and to the long-term maladaptation induced by drug abuse. We then discuss the possible upstreams of the ERK signaling pathway activated by exposure of drugs of abuse and the environmental cues previously paired with drugs. Finally, we argue that since ERK activation is a key molecular process in reinstatement of conditioned place preference and drug self-administration, the pharmacological manipulation of the ERK pathway is a potential treatment strategy for drug addiction.

语种: 英语
WOS记录号: WOS:000253191900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61731
Appears in Collections:中国药物依赖性研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Dept Neuropharmacol, Natl Inst Drug Dependence, Beijing 100083, Peoples R China

Recommended Citation:
Zhai, Haifeng,Li, Yanqin,Wang, Xi,et al. Drug-induced alterations in the extracellular signal-regulated kinase (ERK) signalling pathway: Implications for reinforcement and reinstatement[J]. CELLULAR AND MOLECULAR NEUROBIOLOGY,2008,28(2):157-172.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhai, Haifeng]'s Articles
[Li, Yanqin]'s Articles
[Wang, Xi]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhai, Haifeng]‘s Articles
[Li, Yanqin]‘s Articles
[Wang, Xi]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace