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学科主题基础医学
Antidepressant-like effect of low molecular proanthocyanidin in mice: Involvement of monoaminergic system
Xu, Ying2,3; Li, Shan1,2,3; Chen, Ruijie1; Li, Gaowen1; Barish, Philip A.2,3; You, Wenting1; Chen, Ling1; Lin, Mengmeng1; Ku, Baoshan4; Pan, Jianchun1; Ogle, William O.2,3
关键词Proanthocyanidin Tail suspension Forced swimming Locomotor activity Monoamine Monoamine oxidase
刊名PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
2010
DOI10.1016/j.pbb.2009.10.007
94期:3页:447-453
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]ST-JOHNS-WORT ; BEHAVIORAL DESPAIR ; OXIDASE ACTIVITY ; CURCUMA-LONGA ; GRAPE SEEDS ; DEPRESSION ; EXTRACT ; BRAIN ; RATS ; MODULATION
英文摘要

Proanthocyanidin is a phenolic product present in plants which has antioxidant, antinociceptive and neuroprotective properties, without inducing significant toxicological effects. The present study tested the hypothesis that low molecular proanthocyanidin from grapes that has optimized bioavailability, would exert antidepressant-like activities in behavioral despair tests. The results suggested that oral administration proanthocyanidin at doses of 25 and 50 mg/kg for 7 days significantly reduced the duration of immobility in both the tail suspension and forced swimming tests. The doses that affected the immobile response did not affect locomotor activity. In addition. the neurochemical and neuropharmacological assays showed that proanthocyanidin produced a marked increase of 5-HT levels at 25 and 50 mg/kg in three brain regions, the frontal cortex, hippocampus and hypothalamus. Noradrenaline and dopamine levels were also increased when higher dose of proanthocyanidin (50 mg/kg) administration both in the frontal cortex and hippocampus. These effects were similar to those observed for the classical antidepressant imipramine (10 mg/kg, i.p.). Moreover, Our study suggested that proanthocyanidin (12.5, 25 and 50 mg/kg) dose dependently inhibited monoamine oxidase-A (MAO-A) activity, while MAO-B inhibitory activity was also found at higher doses (25 and 50 mg/kg) after 7 days administration. MAO-A selective inhibitor, moclobemide (20 mg/kg, i.g.) produced MAO-A inhibition of 70.5% in the mouse brain. These findings suggest that the antidepressant-like effects of proanthocyanidin may involve the central monoaminergic neurotransmitter systems. (C) 2009 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000274226500017
项目编号Y20080097
资助机构Ellison Medical Foundation ; Wenzhou Science and Technology Bureau ; Zhejiang Province Extremely Key Subject Building
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61735
专题北京大学基础医学院_药理学系
北京大学基础医学院
作者单位1.Wenzhou Med Coll, Inst Expt Neurobiol, Wenzhou 325021, Peoples R China
2.Univ Florida, J Crayton Pruitt Family Dept Biomed Engn, Gainesville, FL 32611 USA
3.Univ Florida, Evelyn F & William L Mcknight Brain Inst, Gainesville, FL 32611 USA
4.Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100083, Peoples R China
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GB/T 7714
Xu, Ying,Li, Shan,Chen, Ruijie,et al. Antidepressant-like effect of low molecular proanthocyanidin in mice: Involvement of monoaminergic system[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2010,94(3):447-453.
APA Xu, Ying.,Li, Shan.,Chen, Ruijie.,Li, Gaowen.,Barish, Philip A..,...&Ogle, William O..(2010).Antidepressant-like effect of low molecular proanthocyanidin in mice: Involvement of monoaminergic system.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,94(3),447-453.
MLA Xu, Ying,et al."Antidepressant-like effect of low molecular proanthocyanidin in mice: Involvement of monoaminergic system".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 94.3(2010):447-453.
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