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Population pharmacokinetics of rocuronium delivered by target-controlled infusion in adult patients
Yang Lu1; Wang Hui-ling1; Zhang Li-ping1; Bi Shan-shan2; Lu Wei2; Yang Ba-xian3; Guo Xiang-yang1
关键词anesthesia rocuronium pharmacokinetics mass spectrometry
刊名CHINESE MEDICAL JOURNAL
2010-09-20
DOI10.3760/cma.j.issn.0366-6999.2010.18.009
123期:18页:2543-2547
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]SURGICAL-PATIENTS ; PHARMACODYNAMICS ; ORG-9426 ; BROMIDE
英文摘要

Background Target-controlled infusion (TCI) has been recently developed and successfully implemented in clinical practice. The current study was to estimate the population pharmacokinetics of rocuronium TCI in adult patients using nonlinear mixed-effects model (NONMEM), and to investigate the influence of relevant factors in adult patients.

Methods Fourteen ASA I-II patients undergoing elective laparoscopy operation with general anesthesia were included. After induction, all patients received rocuronium by TCI system. The beginning target plasma concentration (Cpt) was 2.0 mu g/ml, then increased Cpt according to the neuromuscular transmission monitoring. The endpoint of Cpt was determined when the T(1) scale was blocked by 90%-95%. TCI rocuronium was stopped 30 minutes before the end of the operation. Arterial blood was drawn before anesthesia at 0, 2, 4, 6, 8, 10, 15, 20, 30, 45, 60, 120, 180, 240 and 360 minutes after the infusion of rocuronium was stopped for the analysis of plasma concentrations of rocuronium by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). The population pharmacokinetics analysis was performed using NONMEM program.

Results The pharmacokinetics of TCI rocuronium in adult patients was best described by a three-comparment model. Pharmacokintic parameters were clearance (CL)(1)=0.205 L/min, CL(2)=0.324 L/min, CL(3)=0.0292 L/min, volumes of distribution (V)(1)=4.00 L, V(2)=2.28 L, V(3)=4.26 L, Vdss=10.54 L. Both age and weight as covariates affected the pharmacokinetic parameters. V(1) and CL(1) were negatively correlated with patient age. CL(1) was positively correlated with weight.

Conclusions No pharmacokinetic change was noted when rocuronium was administered via TCI. Both age and weight as covariates affected the pharmacokinetic parameters. Chin Med J 2010;123(18):2543-2547

语种英语
WOS记录号WOS:000282806200009
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61736
专题北京大学第三临床医学院_麻醉科
北京大学药学院_药剂学系
北京大学口腔医学院_材料检测中心
作者单位1.Peking Univ, Hosp 3, Dept Anesthesiol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Anesthesiol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Yang Lu,Wang Hui-ling,Zhang Li-ping,et al. Population pharmacokinetics of rocuronium delivered by target-controlled infusion in adult patients[J]. CHINESE MEDICAL JOURNAL,2010,123(18):2543-2547.
APA Yang Lu.,Wang Hui-ling.,Zhang Li-ping.,Bi Shan-shan.,Lu Wei.,...&Guo Xiang-yang.(2010).Population pharmacokinetics of rocuronium delivered by target-controlled infusion in adult patients.CHINESE MEDICAL JOURNAL,123(18),2543-2547.
MLA Yang Lu,et al."Population pharmacokinetics of rocuronium delivered by target-controlled infusion in adult patients".CHINESE MEDICAL JOURNAL 123.18(2010):2543-2547.
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