IR@PKUHSC  > 北京大学第三临床医学院  > 麻醉科
学科主题临床医学
Observation of locomotor functional recovery in adult complete spinal rats with BWSTT using semiquantitative and qualitative methods
Zhang, Y.; Ji, S. R.; Wu, C. Y.; Fan, X. H.; Zhou, H. J.; Liu, G. L.
关键词spinal cord injury locomotion functional recovery assessment
刊名SPINAL CORD
2007-07-01
DOI10.1038/sj.sc.3102013
45期:7页:496-501
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Rehabilitation
研究领域[WOS]Neurosciences & Neurology ; Rehabilitation
关键词[WOS]CORD-INJURY ; MOTOR FUNCTION ; ANIMAL-MODELS ; PATTERN ; TRANSECTION ; SYSTEM
英文摘要

Study design: Experimental rat model of spinalcord transection.

Setting: China rehabilitation research center.

Objective: To investigate locomotor functional recovery in spinal rats with BWSTT using semiquantitative and qualitative methods.

Methods: Five- day postoperative ( dpo), adult female complete spinal rats ( at T-8 level) received 40 days of body weight- supported treadmill training ( BWSTT). Signs of functional recovery were examined with average combined scores ( ACOS) and Basso Beattie and Bresnahan ( BBB) scales at different time points.

Results: At 1- dpo, none of the spinal rats exhibited hindlimb movements. The spinal rats displayed functional progress with time, but the rare could recover to full weight- bearing hindlimb at 45- dpo. BBB and ACOS scores in the BWSTT group obtained better scores than those in the spinalcord injury ( SCI) group at 30- and 45- dpo. Furthermore, all BBB and ACOS scores of spinal rats reached statistical significance between 7- and 30- dpo, and between 15- and 30- dpo. However, only ACOS but not BBB scores in the SCI and BWSTT groups showed statistics differences between 15- and 45- dpo, and between 30- and 45- dpo. The Spearman correlation coefficients of BBB and ACOS scores were 0.913 and 0.972 for the SCI and BWSTT groups, respectively.

Conclusions: The results confirmed the existence of partial spontaneous hindlimb functional recovery in adult chronically spinal cord- transected rats, and that BWSTT can improve motor performance. In addition, our study suggests that qualitative and semiquantiative methods are strongly correlated with locomotor recovery in spinal rats, and the latter may be more sensitive in reflecting minor variance at different time points.

语种英语
WOS记录号WOS:000247809000006
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61737
Collection北京大学第三临床医学院_麻醉科
作者单位1.Peking Univ, Hosp 3, Dept Anesthesiol, Beijing, Peoples R China
2.Capital Med Univ, Boai Hosp, China Rehabil Res Ctr, Dept Rehabil, Beijing 100068, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Y.,Ji, S. R.,Wu, C. Y.,et al. Observation of locomotor functional recovery in adult complete spinal rats with BWSTT using semiquantitative and qualitative methods[J]. SPINAL CORD,2007,45(7):496-501.
APA Zhang, Y.,Ji, S. R.,Wu, C. Y.,Fan, X. H.,Zhou, H. J.,&Liu, G. L..(2007).Observation of locomotor functional recovery in adult complete spinal rats with BWSTT using semiquantitative and qualitative methods.SPINAL CORD,45(7),496-501.
MLA Zhang, Y.,et al."Observation of locomotor functional recovery in adult complete spinal rats with BWSTT using semiquantitative and qualitative methods".SPINAL CORD 45.7(2007):496-501.
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