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QiShenYiQi Pills, a compound in Chinese medicine, protects against pressure overload-induced cardiac hypertrophy through a multicomponent and multi-target mode
Chen, Yuan-Yuan1,2,3,4; Li, Quan2,3,4; Pan, Chun-Shui2,3,4; Yan, Li2,3,4; Fan, Jing-Yu2,3,4; He, Ke2,3,4; Sun, Kai2,3,4; Liu, Yu-Ying2,3,4; Chen, Qing-Fang1,2,3,4; Bai, Yan5,6; Wang, Chuan-She1,2,3,4; He, Bing7; Lv, Ai-Ping7; Han, Jing-Yan1,2,3,4
刊名SCIENTIFIC REPORTS
2015-07-02
DOI10.1038/srep11802
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者Production of New Medicine Program of Ministry of Science and Technology of China Grant ; National Natural Science Foundation of China Grant ; Production of New Medicine Program of Ministry of Science and Technology of China Grant ; National Natural Science Foundation of China Grant
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]INDUCED MYOCARDIAL HYPERTROPHY ; ISCHEMIA-REPERFUSION INJURY ; OXIDATIVE STRESS ; HEART-FAILURE ; FATTY-ACID ; METABOLISM ; MECHANISMS ; RAT ; DYSFUNCTION ; PATHWAYS
英文摘要

The present study aimed to explore the holistic mechanism for the antihypertrophic effect of a compound in Chinese medicine, QiShenYiQi Pills (QSYQ) and the contributions of its components to the effect in rats with cardiac hypertrophy (CH). After induction of CH by ascending aortic stenosis, rats were treated with QSYQ, each identified active ingredient (astragaloside IV, 3, 4-dihydroxy-phenyl lactic acid or notoginsenoside R1) from its 3 major herb components or dalbergia odorifera, either alone or combinations, for 1 month. QSYQ markedly attenuated CH, as evidenced by echocardiography, morphology and biochemistry. Proteomic analysis and western blot showed that the majority of differentially expressed proteins in the heart of QSYQ-treated rats were associated with energy metabolism or oxidative stress. Each ingredient alone or their combinations exhibited similar effects as QSYQ but to a lesser extent and differently with astragaloside IV and notoginsenoside R1 being more effective for enhancing energy metabolism, 3, 4-dihydroxy-phenyl lactic acid more effective for counteracting oxidative stress while dalbergia odorifera having little effect on the variables evaluated. In conclusion, QSYQ exerts a more potent antihypertrophic effect than any of its ingredients or their combinations, due to the interaction of its active components through a multi-component and multi-target mode.

语种英语
所属项目编号2013ZX09402202 ; 81273637
资助者Production of New Medicine Program of Ministry of Science and Technology of China Grant ; National Natural Science Foundation of China Grant ; Production of New Medicine Program of Ministry of Science and Technology of China Grant ; National Natural Science Foundation of China Grant
WOS记录号WOS:000357263500001
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61738
专题基础医学院
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100871, Peoples R China
3.State Adm Tradit Chinese Med China, Key Lab Microcirculat, Beijing, Peoples R China
4.State Adm Tradit Chinese Med China, Key Lab Stasis & Phlegm, Beijing, Peoples R China
5.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100871, Peoples R China
6.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptide, Beijing, Peoples R China
7.Hong Kong Baptist Univ, Sch Chinese Med, Kowloon Tong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Chen, Yuan-Yuan,Li, Quan,Pan, Chun-Shui,et al. QiShenYiQi Pills, a compound in Chinese medicine, protects against pressure overload-induced cardiac hypertrophy through a multicomponent and multi-target mode[J]. SCIENTIFIC REPORTS,2015,5.
APA Chen, Yuan-Yuan.,Li, Quan.,Pan, Chun-Shui.,Yan, Li.,Fan, Jing-Yu.,...&Han, Jing-Yan.(2015).QiShenYiQi Pills, a compound in Chinese medicine, protects against pressure overload-induced cardiac hypertrophy through a multicomponent and multi-target mode.SCIENTIFIC REPORTS,5.
MLA Chen, Yuan-Yuan,et al."QiShenYiQi Pills, a compound in Chinese medicine, protects against pressure overload-induced cardiac hypertrophy through a multicomponent and multi-target mode".SCIENTIFIC REPORTS 5(2015).
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