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学科主题: 临床医学
题名:
Growth pattern of renal cell carcinoma (RCC) in patients with delayed surgical intervention
作者: Li, Xue-Song; Yao, Lin; Gong, Kan; Yu, Wei; He, Qun; Zhou, Li-Qun; He, Zhi-Song
关键词: Active surveillance ; Delayed intervention ; Growth rate ; Kidney neoplasms ; Natural history
刊名: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
发表日期: 2012-02-01
DOI: 10.1007/s00432-011-1083-0
卷: 138, 期:2, 页:269-274
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: NATURAL-HISTORY ; ACTIVE SURVEILLANCE ; CONSERVATIVE MANAGEMENT ; MASSES ; METAANALYSIS ; EXPERIENCE ; TUMORS ; RATES
英文摘要:

Purpose Few studies have evaluated the growth pattern of renal cell carcinoma (RCC) in patients with delayed treatment. This report investigated the growth rate and stage progression of incidentally discovered RCC following a long period of active surveillance.

Methods Thirty-two patients who did not receive immediate surgical treatment for renal solid masses that later proved to be RCC were reviewed retrospectively. Annual tumor growth rates were calculated according to changes in the maximal diameter on CT or MRI. Clinical and pathological characteristics associated with tumor growth rate and stage progression were analyzed.

Results The median tumor size grow from 2.14 (range, 0.30-6.70) cm to 4.33 (range, 1.40-8.80) cm after a median 46.0 months observation period. The average tumor growth rate was 0.80 (range, 0.16-3.80) cm/year. Clear cell carcinoma (0.86 cm/year) tended to grow faster than papillary cell carcinoma (0.28 cm/year) (P = 0.066). The mean growth rate of grade 2 tumors (0.88 cm/year) was faster than that of grade 1 tumors (0.36 cm/year) (P = 0.041). Thirteen tumors (40.6%) were upstaged at a median 48 months after initial presentation. Cox regression analysis revealed initial tumor size as the only risk factor for upstaging (P = 0.018). No local and systemic recurrences were noted in our cohort after the intervention at a median of 47 (range, 6-248) months of follow-up.

Conclusions RCCs were found to be slow growing in a group of untreated renal cell carcinoma patients. However, some tumors progressed in stage under observation. The growth rate of RCC tended to correlate with histologic grade and histologic subtype.

语种: 英语
WOS记录号: WOS:000300344800012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61742
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: Peking Univ, Natl Urol Canc Ctr, Inst Urol, Dept Urol,Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Li, Xue-Song,Yao, Lin,Gong, Kan,et al. Growth pattern of renal cell carcinoma (RCC) in patients with delayed surgical intervention[J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,2012,138(2):269-274.
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