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学科主题: 基础医学
题名:
Comparison of brown and white adipose tissue fat fractions in ob, seipin, and Fsp27 gene knockout mice by chemical shift-selective imaging and H-1-MR spectroscopy
作者: Peng, Xin-Gui1; Ju, Shenghong1; Fang, Fang1; Wang, Yu1; Fang, Ke2; Cui, Xin3,4; Liu, George3,4; Li, Peng5; Mao, Hui6; Teng, Gao-Jun1
关键词: brown adipose tissue ; white adipose tissue ; lipid ; magnetic resonance imaging ; spectroscopy
刊名: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
发表日期: 2013
DOI: 10.1152/ajpendo.00401.2012
卷: 304, 期:2, 页:E160-E167
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Physiology
研究领域[WOS]: Endocrinology & Metabolism ; Physiology
关键词[WOS]: ADULT HUMANS ; 4.7 TESLA ; IN-VIVO ; LIPODYSTROPHY ; OBESITY ; IDENTIFICATION ; LEPTIN ; MRI
英文摘要:

Peng X, Ju S, Fang F, Wang Y, Fang K, Cui X, Liu G, Li P, Mao H, Teng G. Comparison of brown and white adipose tissue fat fractions in ob, seipin, and Fsp27 gene knockout mice by chemical shift-selective imaging and 1H-MR spectroscopy. Am J Physiol Endocrinol Metab 304: E160-E167, 2013. First published November 13, 2012; doi:10.1152/ajpendo.00401.2012.-Brown adipose tissue (BAT) plays a key role in thermogenesis to protect the body from cold and obesity. White adipose tissue (WAT) stores excess energy in the form of triglycerides. To better understand the genetic effect on regulation of WAT and BAT, we investigated the fat fraction (FF) in two types of adipose tissues in ob/ob, human BSCL2/seipin gene knockout (SKO), Fsp27 gene knockout (Fsp27(-/-)), and wild-type (WT) mice in vivo using chemical shift selective imaging and 1H-MR spectroscopy. We reported that the visceral fat volume in WAT was significantly larger in ob/ob mice, but visceral fat volumes were lower in SKO and Fsp27(-/-) mice compared with WT mice. BAT FF was significantly higher in ob/ob mice than the WT group and similar to that of WAT. In contrast, WAT FFs in SKO and Fsp27(-/-) mice were lower and similar to that of BAT. The adipocyte size of WAT in ob/ob mice and the BAT adipocyte size in ob/ob, SKO, and Fsp27 mice were significantly larger compared with WT mice. However, the WAT adipocyte size was significantly smaller in SKO mice than in WT mice. Positive correlations were observed between the adipocyte size and FFs of WAT and BAT. These results suggested that smaller adipocyte size correlates with lower FFs of WAT and BAT. In addition, the differences in FFs in WAT and BAT measured by MR methods in different mouse models were related to the different regulation effects of ob, seipin, or Fsp27 gene on developing WAT and BAT.

语种: 英语
所属项目编号: 2010CB933903 ; 30830039 ; 81071125 ; YBJJ1204
项目资助者: Major State Basic Research Development Program of China (973 Program) ; National Nature Science Foundation of China ; Scientific Research Foundation of the Graduate School of Southeast University
WOS记录号: WOS:000313614700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61746
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Bruker BioSpin, Beijing, Peoples R China
2.Emory Univ, Sch Med, Dept Radiol & Imaging Sci, Atlanta, GA USA
3.Southeast Univ, Sch Med, Zhongda Hosp, Jiangsu Key Lab Mol & Funct Imaging,Dept Radiol, Nanjing 210009, Jiangsu, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100871, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100871, Peoples R China
6.Tsinghua Univ, Minist Educ, Prot Sci Lab, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China

Recommended Citation:
Peng, Xin-Gui,Ju, Shenghong,Fang, Fang,et al. Comparison of brown and white adipose tissue fat fractions in ob, seipin, and Fsp27 gene knockout mice by chemical shift-selective imaging and H-1-MR spectroscopy[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,2013,304(2):E160-E167.
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