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学科主题基础医学
Comparison of brown and white adipose tissue fat fractions in ob, seipin, and Fsp27 gene knockout mice by chemical shift-selective imaging and H-1-MR spectroscopy
Peng, Xin-Gui1; Ju, Shenghong1; Fang, Fang1; Wang, Yu1; Fang, Ke2; Cui, Xin3,4; Liu, George3,4; Li, Peng5; Mao, Hui6; Teng, Gao-Jun1
关键词brown adipose tissue white adipose tissue lipid magnetic resonance imaging spectroscopy
刊名AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
2013
DOI10.1152/ajpendo.00401.2012
304期:2页:E160-E167
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Physiology
研究领域[WOS]Endocrinology & Metabolism ; Physiology
关键词[WOS]ADULT HUMANS ; 4.7 TESLA ; IN-VIVO ; LIPODYSTROPHY ; OBESITY ; IDENTIFICATION ; LEPTIN ; MRI
英文摘要

Peng X, Ju S, Fang F, Wang Y, Fang K, Cui X, Liu G, Li P, Mao H, Teng G. Comparison of brown and white adipose tissue fat fractions in ob, seipin, and Fsp27 gene knockout mice by chemical shift-selective imaging and 1H-MR spectroscopy. Am J Physiol Endocrinol Metab 304: E160-E167, 2013. First published November 13, 2012; doi:10.1152/ajpendo.00401.2012.-Brown adipose tissue (BAT) plays a key role in thermogenesis to protect the body from cold and obesity. White adipose tissue (WAT) stores excess energy in the form of triglycerides. To better understand the genetic effect on regulation of WAT and BAT, we investigated the fat fraction (FF) in two types of adipose tissues in ob/ob, human BSCL2/seipin gene knockout (SKO), Fsp27 gene knockout (Fsp27(-/-)), and wild-type (WT) mice in vivo using chemical shift selective imaging and 1H-MR spectroscopy. We reported that the visceral fat volume in WAT was significantly larger in ob/ob mice, but visceral fat volumes were lower in SKO and Fsp27(-/-) mice compared with WT mice. BAT FF was significantly higher in ob/ob mice than the WT group and similar to that of WAT. In contrast, WAT FFs in SKO and Fsp27(-/-) mice were lower and similar to that of BAT. The adipocyte size of WAT in ob/ob mice and the BAT adipocyte size in ob/ob, SKO, and Fsp27 mice were significantly larger compared with WT mice. However, the WAT adipocyte size was significantly smaller in SKO mice than in WT mice. Positive correlations were observed between the adipocyte size and FFs of WAT and BAT. These results suggested that smaller adipocyte size correlates with lower FFs of WAT and BAT. In addition, the differences in FFs in WAT and BAT measured by MR methods in different mouse models were related to the different regulation effects of ob, seipin, or Fsp27 gene on developing WAT and BAT.

语种英语
WOS记录号WOS:000313614700005
项目编号2010CB933903 ; 30830039 ; 81071125 ; YBJJ1204
资助机构Major State Basic Research Development Program of China (973 Program) ; National Nature Science Foundation of China ; Scientific Research Foundation of the Graduate School of Southeast University
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61746
专题北京大学基础医学院_心血管所
北京大学精神卫生研究所_精神科
作者单位1.Bruker BioSpin, Beijing, Peoples R China
2.Emory Univ, Sch Med, Dept Radiol & Imaging Sci, Atlanta, GA USA
3.Southeast Univ, Sch Med, Zhongda Hosp, Jiangsu Key Lab Mol & Funct Imaging,Dept Radiol, Nanjing 210009, Jiangsu, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100871, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100871, Peoples R China
6.Tsinghua Univ, Minist Educ, Prot Sci Lab, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China
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Peng, Xin-Gui,Ju, Shenghong,Fang, Fang,et al. Comparison of brown and white adipose tissue fat fractions in ob, seipin, and Fsp27 gene knockout mice by chemical shift-selective imaging and H-1-MR spectroscopy[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,2013,304(2):E160-E167.
APA Peng, Xin-Gui.,Ju, Shenghong.,Fang, Fang.,Wang, Yu.,Fang, Ke.,...&Teng, Gao-Jun.(2013).Comparison of brown and white adipose tissue fat fractions in ob, seipin, and Fsp27 gene knockout mice by chemical shift-selective imaging and H-1-MR spectroscopy.AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,304(2),E160-E167.
MLA Peng, Xin-Gui,et al."Comparison of brown and white adipose tissue fat fractions in ob, seipin, and Fsp27 gene knockout mice by chemical shift-selective imaging and H-1-MR spectroscopy".AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 304.2(2013):E160-E167.
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