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学科主题: 基础医学
题名:
MicroRNA expression profiling and functional annotation analysis of their targets associated with the malignant transformation of oral leukoplakia
作者: Maimaiti, Aikebaier1,2; Abudoukeremu, Kaisaier3; Tie, Lu1,2; Pan, Yan1,2; Li, Xuejun1,2
关键词: Oral leukoplakia ; MicroRNA microarray ; Expression profiles ; Malignant transformation
刊名: GENE
发表日期: 2015-03-10
DOI: 10.1016/j.gene.2015.01.004
卷: 558, 期:2, 页:271-277
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: SQUAMOUS-CELL CARCINOMAS ; PREMALIGNANT LESIONS ; CANCER CELLS ; IDENTIFICATION ; CYTOSCAPE ; MIR-129-5P ; MIGRATION ; NETWORKS ; GROWTH
英文摘要:

In spite the tremendous achievements that have been acquired in the field of molecular biology, the underlying mechanism associated with malignant transformed oral leukoplakia (OLK) is still unclear and poorly understood. The aim of this study is to investigate the microRNA (miRNA) expression profiles in OLK and its aggressive transformed tissues from the white lesion of human oral mucosa. The original miRNA expression dataset was downloaded from Gene Expression Omnibus (GEO) database and differentially expressed miRNAs were identified using two-sample t test method. Unsupervised hierarchical clustering and principal component analysis of these differentially expressed miRNAs indicated that 38-miRNA candidates could significantly discriminate OLK from malignant transformed oral mucosa samples. Besides, potential transcription factors were predicted using CyTargetLinker plugin and the miRNA-mRNA regulatory network associated with the malignant pathogenesis was visualized in Cytoscape environment. Totally, 3-miRNA signatures (miR-129-5p, miR-339-5p and miR-31*) were found to be hubs that mediated the initiation and progression of OLK from the non-malignant to the aggressive one via targeting various transcription factors. Functional enrichment analysis based on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) suggested that the dysregulation of immune response was responsible for oral carcinogenesis. In conclusion, we constructed a miRNA-mRNA regulatory network associated with the malignant transformation of OLK, and screened out some miRNAs and transcription factors that may have prominent roles during OLK malignant progression. (C) 2015 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 91129727 ; 81020108031 ; 81473235 ; 81270049 ; 81373405 ; B07001
项目资助者: National Natural Science Foundation of China ; Research Fund from Ministry of Education of the People&prime ; s Republic of China (111 Projects)
WOS记录号: WOS:000350089300013
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61749
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, State Key Lab Nat & Biomimet Drugs,Dept Pharmacol, Beijing 100191, Peoples R China
2.Peking Univ, Beijing Key Lab Tumor Syst Biol, Beijing 100191, Peoples R China
3.Xinjiang Uyghur Med Sch, Hetian 848000, Peoples R China

Recommended Citation:
Maimaiti, Aikebaier,Abudoukeremu, Kaisaier,Tie, Lu,et al. MicroRNA expression profiling and functional annotation analysis of their targets associated with the malignant transformation of oral leukoplakia[J]. GENE,2015,558(2):271-277.
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