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学科主题基础医学
MicroRNA expression profiling and functional annotation analysis of their targets associated with the malignant transformation of oral leukoplakia
Maimaiti, Aikebaier1,2; Abudoukeremu, Kaisaier3; Tie, Lu1,2; Pan, Yan1,2; Li, Xuejun1,2
关键词Oral leukoplakia MicroRNA microarray Expression profiles Malignant transformation
刊名GENE
2015-03-10
DOI10.1016/j.gene.2015.01.004
558期:2页:271-277
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
研究领域[WOS]Genetics & Heredity
关键词[WOS]SQUAMOUS-CELL CARCINOMAS ; PREMALIGNANT LESIONS ; CANCER CELLS ; IDENTIFICATION ; CYTOSCAPE ; MIR-129-5P ; MIGRATION ; NETWORKS ; GROWTH
英文摘要

In spite the tremendous achievements that have been acquired in the field of molecular biology, the underlying mechanism associated with malignant transformed oral leukoplakia (OLK) is still unclear and poorly understood. The aim of this study is to investigate the microRNA (miRNA) expression profiles in OLK and its aggressive transformed tissues from the white lesion of human oral mucosa. The original miRNA expression dataset was downloaded from Gene Expression Omnibus (GEO) database and differentially expressed miRNAs were identified using two-sample t test method. Unsupervised hierarchical clustering and principal component analysis of these differentially expressed miRNAs indicated that 38-miRNA candidates could significantly discriminate OLK from malignant transformed oral mucosa samples. Besides, potential transcription factors were predicted using CyTargetLinker plugin and the miRNA-mRNA regulatory network associated with the malignant pathogenesis was visualized in Cytoscape environment. Totally, 3-miRNA signatures (miR-129-5p, miR-339-5p and miR-31*) were found to be hubs that mediated the initiation and progression of OLK from the non-malignant to the aggressive one via targeting various transcription factors. Functional enrichment analysis based on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) suggested that the dysregulation of immune response was responsible for oral carcinogenesis. In conclusion, we constructed a miRNA-mRNA regulatory network associated with the malignant transformation of OLK, and screened out some miRNAs and transcription factors that may have prominent roles during OLK malignant progression. (C) 2015 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000350089300013
项目编号91129727 ; 81020108031 ; 81473235 ; 81270049 ; 81373405 ; B07001
资助机构National Natural Science Foundation of China ; Research Fund from Ministry of Education of the People&prime ; s Republic of China (111 Projects)
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61749
专题北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, State Key Lab Nat & Biomimet Drugs,Dept Pharmacol, Beijing 100191, Peoples R China
2.Peking Univ, Beijing Key Lab Tumor Syst Biol, Beijing 100191, Peoples R China
3.Xinjiang Uyghur Med Sch, Hetian 848000, Peoples R China
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GB/T 7714
Maimaiti, Aikebaier,Abudoukeremu, Kaisaier,Tie, Lu,et al. MicroRNA expression profiling and functional annotation analysis of their targets associated with the malignant transformation of oral leukoplakia[J]. GENE,2015,558(2):271-277.
APA Maimaiti, Aikebaier,Abudoukeremu, Kaisaier,Tie, Lu,Pan, Yan,&Li, Xuejun.(2015).MicroRNA expression profiling and functional annotation analysis of their targets associated with the malignant transformation of oral leukoplakia.GENE,558(2),271-277.
MLA Maimaiti, Aikebaier,et al."MicroRNA expression profiling and functional annotation analysis of their targets associated with the malignant transformation of oral leukoplakia".GENE 558.2(2015):271-277.
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