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学科主题: 临床医学
题名:
Urothelial carcinoma of the bladder in patients aged 30 years or younger: clinicopathological analysis and expression of fibroblast growth factor receptor 3 (FGFR3) of 45 cases
作者: Huang, Haichao1,2; Sun, Mengkui1,2; Li, Xin1,2; Jin, Jie1,2
关键词: Urothelial carcinoma ; Bladder ; Young ; FGFR3
刊名: MEDICAL ONCOLOGY
发表日期: 2015-05-01
DOI: 10.1007/s12032-015-0581-3
卷: 32, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: TRANSITIONAL-CELL CARCINOMA ; TP53 GENE-MUTATIONS ; MOLECULAR CHARACTERISTICS ; URINARY-BLADDER ; ADULTS ; TUMORS ; NEOPLASMS ; CHILDREN ; CANCER ; PATHWAYS
英文摘要:

The aim of this study was to demonstrate the clinicopathological features, prognostic outcomes and fibroblast growth factor receptor 3 (FGFR3) protein expression status of a large series (n = 45) of urothelial carcinoma of bladder patients aged 30 or younger, retrospectively. We identified an age gradient (an age of 25, 26 and 27 years), classified patients as <= 25 or >25, <= 26 or >26, <= 27 or >27 years, respectively, and compared variables including recurrence events and FGFR3 expression patterns between different groups. Patients aged 25 years or younger were less likely to experience tumor recurrence (p = 0.046), were more likely to develop smaller size tumors (p = 0.040) and expressed more proportion of negative pattern of FGFR3 protein (p = 0.036). Patients aged 25 years or younger were less likely to develop tumor recurrence and revealed more proportion of negative pattern of FGFR3 expression than those aged 26-30 years did. We identified patients aged 25 years or younger as the true "young" urothelial carcinoma patients, carrying distinct clinical outcomes and molecular tumorigenesis.

语种: 英语
WOS记录号: WOS:000352152000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61750
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
2.Peking Univ, Natl Urol Canc Ctr, Inst Urol, Beijing 100034, Peoples R China

Recommended Citation:
Huang, Haichao,Sun, Mengkui,Li, Xin,et al. Urothelial carcinoma of the bladder in patients aged 30 years or younger: clinicopathological analysis and expression of fibroblast growth factor receptor 3 (FGFR3) of 45 cases[J]. MEDICAL ONCOLOGY,2015,32(5).
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