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学科主题: 药学
题名:
Preparation and characterization of superparamagnetic iron oxide nanoparticles stabilized by alginate
作者: Ma, Hui-li; Qi, Xian-tong; Maitani, Yoshie; Nagai, Tsuneji
关键词: alginate ; superparamagnetic iron oxide nanoparticles (SPION) ; magnetometric ; atomic force microscopy (AFM) ; magnetic resonance imaging (MRI)
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2007-03-21
DOI: 10.1016/j.ijpharm.2006.10.006
卷: 333, 期:1-2, 页:177-186
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: BIOMEDICAL APPLICATIONS ; CONTRAST AGENTS ; MAGNETIC FLUIDS ; IN-VITRO ; PARTICLES ; IRON(III) ; HYPERTHERMIA ; RELAXIVITY ; POLYMERS ; RATIOS
英文摘要:

SPION with appropriate surface chemistry have been widely used experimentally for numerous in vivo applications. In this study, SPION stabilized by alginate (SPION-alginate) were prepared by a modified coprecipitation method. The structure, size, morphology, magnetic property and relaxivity of the SPION-alginate were characterized systematically by means of XRD, TEM, ESEM, AFM, DJLS, SQUID magnetometer and MRI, respectively, and the interaction between alginate and iron oxide (Fe3O4) was characterized by FT-IR and AFM. The results revealed that typical iron oxide nanoparticles were Fe3O4 With a core diameter of 5-10 nm and SPION-alginate had a hydrodynamic diameter of 193.8-483.2 nm. From the magnetization curve, the Ms of a suspension of SPION-alginate was 40 emu/g, corresponding to 73% of that of solid SPION-alginate. This high Ms may be due to the binding of Fe3O4 nanoparticles to alginate macromolecule strands as visually confirmed by AFM. SPION-alginate of several hundred nanometers was stable in size for 12 months at 4 degrees C. Moreover, T1 relaxivity and T2 relaxivity of SPION-alginate in saline (1.5 T, 20 degrees C) were 7.86 +/- 0.20 s(-1) mM(-1) and 281.2 +/- 26.4 s(-1) mM(-1), respectively. (c) 2006 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000245309900023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61754
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Hoshi Univ, Inst Med Chem, Shinagawa Ku, Tokyo 142850, Japan
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China

Recommended Citation:
Ma, Hui-li,Qi, Xian-tong,Maitani, Yoshie,et al. Preparation and characterization of superparamagnetic iron oxide nanoparticles stabilized by alginate[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2007,333(1-2):177-186.
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