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学科主题: 药物依赖
题名:
Insular muscarinic signaling regulates anxiety-like behaviors in rats on the elevated plus-maze
作者: Li, Hui1; Chen, Lei1; Li, Peng2; Wang, Xiaohong2; Zhai, Haifeng1
关键词: Insula ; Anxiety ; Elevated plus-maze ; Muscarinic acetylcholine receptor
刊名: BEHAVIOURAL BRAIN RESEARCH
发表日期: 2014-08-15
DOI: 10.1016/j.bbr.2014.05.017
卷: 270, 页:256-260
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]: TASTE MEMORY FORMATION ; CHOLINERGIC ACTIVITY ; RECOGNITION MEMORY ; CORTEX ; RECEPTORS ; NUCLEUS ; CONSOLIDATION ; ACTIVATION ; PATHWAYS ; DISORDER
英文摘要:

Anxiety is one of the most prevalent neuropsychiatric disorders, and little is known about its pathogenesis. In order to investigate the neural mechanisms of this mental disorder, we used rat behavior in the elevated plus-maze as an animal model of anxiety and the insular cortex (insula) as a brain target. The microinjection of non-selective and selective M-1 and M-4 muscarinic acetylcholine receptor (mAChR) agonists or antagonists was used to explore whether the insular muscarinic receptor and its subtypes regulate levels of anxiety. The results showed that both non-selective and selective M-1 and M-4 mAChR agonists increased the time spent on exploring in the open arms, whereas antagonists decreased exploration. Our results indicate that activation of insular mAChRs could produce anxiolytic effects, whereas inhibition of insular mAChRs could increase anxiety. We concluded that the insular muscarinic system plays a role in the modulation of anxiety, and dysfunction of mAChR signaling may be involved in the mechanism of anxiogenesis. (C) 2014 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30873051 ; 81271473 ; 7112087
项目资助者: National Natural Science Foundation ; Beijing Municipal Natural Science Foundation of China
WOS记录号: WOS:000339694200031
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61759
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Sch Chinese Met Med, Beijing 100102, Peoples R China

Recommended Citation:
Li, Hui,Chen, Lei,Li, Peng,et al. Insular muscarinic signaling regulates anxiety-like behaviors in rats on the elevated plus-maze[J]. BEHAVIOURAL BRAIN RESEARCH,2014,270:256-260.
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