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Insular muscarinic signaling regulates anxiety-like behaviors in rats on the elevated plus-maze
Li, Hui1; Chen, Lei1; Li, Peng2; Wang, Xiaohong2; Zhai, Haifeng1
关键词Insula Anxiety Elevated plus-maze Muscarinic acetylcholine receptor
刊名BEHAVIOURAL BRAIN RESEARCH
2014-08-15
DOI10.1016/j.bbr.2014.05.017
270页:256-260
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences
资助者National Natural Science Foundation ; Beijing Municipal Natural Science Foundation of China ; National Natural Science Foundation ; Beijing Municipal Natural Science Foundation of China
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]TASTE MEMORY FORMATION ; CHOLINERGIC ACTIVITY ; RECOGNITION MEMORY ; CORTEX ; RECEPTORS ; NUCLEUS ; CONSOLIDATION ; ACTIVATION ; PATHWAYS ; DISORDER
英文摘要

Anxiety is one of the most prevalent neuropsychiatric disorders, and little is known about its pathogenesis. In order to investigate the neural mechanisms of this mental disorder, we used rat behavior in the elevated plus-maze as an animal model of anxiety and the insular cortex (insula) as a brain target. The microinjection of non-selective and selective M-1 and M-4 muscarinic acetylcholine receptor (mAChR) agonists or antagonists was used to explore whether the insular muscarinic receptor and its subtypes regulate levels of anxiety. The results showed that both non-selective and selective M-1 and M-4 mAChR agonists increased the time spent on exploring in the open arms, whereas antagonists decreased exploration. Our results indicate that activation of insular mAChRs could produce anxiolytic effects, whereas inhibition of insular mAChRs could increase anxiety. We concluded that the insular muscarinic system plays a role in the modulation of anxiety, and dysfunction of mAChR signaling may be involved in the mechanism of anxiogenesis. (C) 2014 Elsevier B.V. All rights reserved.

语种英语
所属项目编号30873051 ; 81271473 ; 7112087
资助者National Natural Science Foundation ; Beijing Municipal Natural Science Foundation of China ; National Natural Science Foundation ; Beijing Municipal Natural Science Foundation of China
WOS记录号WOS:000339694200031
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61759
专题中国药物依赖性研究所
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Sch Chinese Met Med, Beijing 100102, Peoples R China
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GB/T 7714
Li, Hui,Chen, Lei,Li, Peng,et al. Insular muscarinic signaling regulates anxiety-like behaviors in rats on the elevated plus-maze[J]. BEHAVIOURAL BRAIN RESEARCH,2014,270:256-260.
APA Li, Hui,Chen, Lei,Li, Peng,Wang, Xiaohong,&Zhai, Haifeng.(2014).Insular muscarinic signaling regulates anxiety-like behaviors in rats on the elevated plus-maze.BEHAVIOURAL BRAIN RESEARCH,270,256-260.
MLA Li, Hui,et al."Insular muscarinic signaling regulates anxiety-like behaviors in rats on the elevated plus-maze".BEHAVIOURAL BRAIN RESEARCH 270(2014):256-260.
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