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学科主题: 临床医学
题名:
Subcutaneous phaeohyphomycotic cyst caused by Pyrenochaeta romeroi
作者: Badali, H.1,2,3,4; Chander, J.5; Gulati, N.5; Attri, A.6; Chopra, R.7; Najafzadeh, M. J.1,2; Chhabra, S.7; Meis, J. F. G. M.8; De Hoog, G. S.1,2,9
关键词: Subcutaneous infection ; phaeohyphomycotic cyst ; Pyrenochaeta romeroi ; ITS rDNA ; in vitro antifungal susceptibility
刊名: MEDICAL MYCOLOGY
发表日期: 2010-08-01
DOI: 10.3109/13693780903440383
卷: 48, 期:5, 页:763-768
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Mycology ; Veterinary Sciences
研究领域[WOS]: Mycology ; Veterinary Sciences
关键词[WOS]: INFECTION ; PHOMA
英文摘要:

Pyrenochaeta romeroi is a rare agent of chronic, suppurative subcutaneous infections which ultimately lead to mycetoma. It has only rarely been reported from deep, non-mycetomatous infections. We describe a case of a subcutaneous phaeohyphomycotic cyst in a 45-year-old Indian female who suffered from verrucous plaque and a swelling (30 mm in diameter) on the right forearm that gradually increased in size over a period of 3 months. Direct microscopic examination with 10% KOH and histopathological investigation of exudates revealed septate hyphae without granules, the hallmark of mycetoma. The lesion appeared to be a subcutaneous phaeohyphomycotic cyst caused by P. romeroi. The suspected agent was recovered in culture, identified on the basis of morphologic features and its identification confirmed by sequencing of the internal transcribed spacer regions of rDNA. Treatment consisted of surgical excising of the cyst without any antifungal therapy. There was no relapse during a one-year follow-up and the patient was successfully cured. In vitro antifungal susceptibility tests demonstrated that itraconazole (0.5 mu g/ml), isavuconazole (0.125 mu g/ml) and posaconazole (0.5 mu g/ml) had potent activity against this isolate of P. romeroi. High MICs were found with amphotericin B (4 mu g/ml), fluconazole (> 64 mu g/ml), voriconazole (4 mu g/ml) and caspofungin (8 mu g/ml). However, their clinical effectiveness in the treatment of P. romeroi infections remains to be evaluated.

语种: 英语
所属项目编号: 13081
项目资助者: Ministry of Health and Medical Education of the Islamic Republic of Iran ; School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
WOS记录号: WOS:000280700800011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61760
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Govt Med Coll Hosp, Dept Gen Surg, Chandigarh 160030, India
2.Govt Med Coll Hosp, Dept Pathol, Chandigarh 160030, India
3.CBS KNAW Fungal Biodivers Ctr, NL-3508 AD Utrecht, Netherlands
4.Mazandaran Univ Med Sci, Cell Biol Res Ctr, Sari, Iran
5.Govt Med Coll Hosp, Dept Microbiol, Chandigarh 160030, India
6.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
7.Mazandaran Univ Med Sci, Dept Med Mycol & Parasitol, Sch Med Mol, Sari, Iran
8.Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands
9.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China

Recommended Citation:
Badali, H.,Chander, J.,Gulati, N.,et al. Subcutaneous phaeohyphomycotic cyst caused by Pyrenochaeta romeroi[J]. MEDICAL MYCOLOGY,2010,48(5):763-768.
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