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学科主题: 临床医学
题名:
Mycoplasma pneumoniae pneumonia in hospitalized children diagnosed at acute stage by paired sera
作者: Liu Chun-ling1; Wang Gui-qiang6,7; Zhang Bo2; Xu Hua3; Hu Liang-ping8; He Xiao-feng4; Wang Jun-hua5; Zhang Jun-hong3; Liu Xiao-yu3; Wei Ming3; Liu Zhen-ye4
关键词: mycoplasma ; pneumonia children ; serum ; antibodies
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2010-12-05
DOI: 10.3760/cma.j.issn.0366-6999.2010.23.013
卷: 123, 期:23, 页:3444-3450
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: COMMUNITY-ACQUIRED PNEUMONIA ; CLINICAL-FEATURES ; INFECTION ; OUTBREAK ; EPIDEMIOLOGY ; MANAGEMENT ; CHILDHOOD ; CULTURE ; DISEASE ; ADULTS
英文摘要:

Background Mycoplasma pneumoniae (M pneumoniae) is a frequent cause of respiratory tract infections However, there is deficient knowledge about the clinical manifestations of M pneumoniae infection We described the clinical and laboratory findings of M pneumoniae pneumonia in hospitalized children who were all diagnosed by a >= fourfold increase in antibody titer

Methods M pneumoniae antibodies were routinely detected in children admitted with acute respiratory infection during a one-year period The medical history was re-collected from children whose M pneumoniae antibody titer increased >= fourfold at the bedside by a single person, and their frozen paired serum samples were measured again for the M pneumoniae antibody titer

Results Of the 635 children whose sera were detected for the M pneumoniae antibody paired sera were obtained from 82 and 29 3% (24/82) showed a >= fourfold increase in antibody titer There were 24 cases nine boys and 15 girls, aged from two to 14 years, whose second serum samples were taken on day 9 at the earliest after symptom onset, the shortest interval was three days All children presented with a high fever (>= 38 5 degrees C) and coughing Twenty one had no nasal obstruction or a runny nose and five had mild headaches which all were associated with the high fever The disease was comparatively severe if the peak temperature was >39 5 degrees C All were diagnosed as having pneumonia through chest X-rays Four had bilateral or multilobar involvement and their peak temperatures were all <= 39 5 degrees C None of the children had difficulty in breathing and all showed no signs of wheezing

Conclusions The second serum sample could be taken on day 9 at the earliest after symptom onset meant that paired sera could be used for the clinical diagnosis of M pneumoniae pneumonia in children at the acute stage M pneumoniae is a lower respiratory tract pathogen Extrapulmonary complications were rare and minor in our study High peak temperature (>39 5 degrees C) is correlated with the severity of M pneumoniae pneumonia in children

语种: 英语
WOS记录号: WOS:000285401100013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61763
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Air Force Gen Hosp Chinese Peoples Liberat Army, Dept Infect Dis, Beijing 100142, Peoples R China
2.Air Force Gen Hosp Chinese Peoples Liberat Army, Dept Respirat, Beijing 100142, Peoples R China
3.Air Force Gen Hosp Chinese Peoples Liberat Army, Dept Pediat, Beijing 100142, Peoples R China
4.Air Force Gen Hosp Chinese Peoples Liberat Army, Dept Infect Control, Beijing 100142, Peoples R China
5.Air Force Gen Hosp Chinese Peoples Liberat Army, Dept Cardiol, Beijing 100142, Peoples R China
6.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China
7.Peking Univ, Hosp 1, Ctr Liver Dis, Beijing 100034, Peoples R China
8.Acad Mil Med Sci, Consulting Ctr Biomed Stat, Beijing 100850, Peoples R China

Recommended Citation:
Liu Chun-ling,Wang Gui-qiang,Zhang Bo,et al. Mycoplasma pneumoniae pneumonia in hospitalized children diagnosed at acute stage by paired sera[J]. CHINESE MEDICAL JOURNAL,2010,123(23):3444-3450.
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