北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 细胞生物学系  > 期刊论文
学科主题: 基础医学
题名:
Overexpression of LAPTM4B-35 promotes growth and metastasis of hepatocellular carcinoma in vitro and in vivo
作者: Yang, Hua1; Xiong, Fuxia1; Wei, Xuanhui1; Yang, Yu2; McNutt, Michael A.2; Zhou, Rouli1
关键词: LAPTM4B-35 ; HCC ; Tumorigenesis ; Cell cycle ; AKT
刊名: CANCER LETTERS
发表日期: 2010-08-28
DOI: 10.1016/j.canlet.2010.02.006
卷: 294, 期:2, 页:236-244
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CYCLIN D1 ; CELL-CYCLE ; MYC ; PATHWAY ; CANCER ; TRANSCRIPTION ; EXPRESSION ; INHIBITION ; P27(KIP1) ; COMPLEXES
英文摘要:

LAPTM4B-35, encoded by Lysosomal protein transmembrane 4 beta (LAPTM4B) is over-expressed in more than 71% of hepatocellular carcinomas (HCCs) and associated with prognosis of the patients. But the exact role and molecular mechanism in HCC have not been determined. In this study, we explored the effects and mechanisms of LAPTM4B-35 on tumor growth and metastasis in vitro and in vivo by overexpression and depletion of LAPTM4B in HCC HepG2 and Bel7402 cells. These findings suggest that overexpression of LAPTM4B-35 plays a critical role in the growth and metastasis of HCC, and LAPTM4B-35 may therefore be a therapeutic target for HCC. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2006AA02A305 ; H020220020310
项目资助者: National High Technology Research and Development Program of China ; Special funds for promotion of education ; Ministry of Education ; 985 Foundation of Peking University ; 248 major R&amp ; D program of Beijing China
WOS记录号: WOS:000279064700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61767
Appears in Collections:基础医学院_细胞生物学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Hua,Xiong, Fuxia,Wei, Xuanhui,et al. Overexpression of LAPTM4B-35 promotes growth and metastasis of hepatocellular carcinoma in vitro and in vivo[J]. CANCER LETTERS,2010,294(2):236-244.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yang, Hua]'s Articles
[Xiong, Fuxia]'s Articles
[Wei, Xuanhui]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yang, Hua]‘s Articles
[Xiong, Fuxia]‘s Articles
[Wei, Xuanhui]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace