IR@PKUHSC  > 北京大学基础医学院  > 细胞生物学系
学科主题基础医学
Overexpression of LAPTM4B-35 promotes growth and metastasis of hepatocellular carcinoma in vitro and in vivo
Yang, Hua1; Xiong, Fuxia1; Wei, Xuanhui1; Yang, Yu2; McNutt, Michael A.2; Zhou, Rouli1
关键词LAPTM4B-35 HCC Tumorigenesis Cell cycle AKT
刊名CANCER LETTERS
2010-08-28
DOI10.1016/j.canlet.2010.02.006
294期:2页:236-244
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CYCLIN D1 ; CELL-CYCLE ; MYC ; PATHWAY ; CANCER ; TRANSCRIPTION ; EXPRESSION ; INHIBITION ; P27(KIP1) ; COMPLEXES
英文摘要

LAPTM4B-35, encoded by Lysosomal protein transmembrane 4 beta (LAPTM4B) is over-expressed in more than 71% of hepatocellular carcinomas (HCCs) and associated with prognosis of the patients. But the exact role and molecular mechanism in HCC have not been determined. In this study, we explored the effects and mechanisms of LAPTM4B-35 on tumor growth and metastasis in vitro and in vivo by overexpression and depletion of LAPTM4B in HCC HepG2 and Bel7402 cells. These findings suggest that overexpression of LAPTM4B-35 plays a critical role in the growth and metastasis of HCC, and LAPTM4B-35 may therefore be a therapeutic target for HCC. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000279064700013
项目编号2006AA02A305 ; H020220020310
资助机构National High Technology Research and Development Program of China ; Special funds for promotion of education ; Ministry of Education ; 985 Foundation of Peking University ; 248 major R&amp ; D program of Beijing China
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61767
专题北京大学基础医学院_细胞生物学系
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yang, Hua,Xiong, Fuxia,Wei, Xuanhui,et al. Overexpression of LAPTM4B-35 promotes growth and metastasis of hepatocellular carcinoma in vitro and in vivo[J]. CANCER LETTERS,2010,294(2):236-244.
APA Yang, Hua,Xiong, Fuxia,Wei, Xuanhui,Yang, Yu,McNutt, Michael A.,&Zhou, Rouli.(2010).Overexpression of LAPTM4B-35 promotes growth and metastasis of hepatocellular carcinoma in vitro and in vivo.CANCER LETTERS,294(2),236-244.
MLA Yang, Hua,et al."Overexpression of LAPTM4B-35 promotes growth and metastasis of hepatocellular carcinoma in vitro and in vivo".CANCER LETTERS 294.2(2010):236-244.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, Hua]的文章
[Xiong, Fuxia]的文章
[Wei, Xuanhui]的文章
百度学术
百度学术中相似的文章
[Yang, Hua]的文章
[Xiong, Fuxia]的文章
[Wei, Xuanhui]的文章
必应学术
必应学术中相似的文章
[Yang, Hua]的文章
[Xiong, Fuxia]的文章
[Wei, Xuanhui]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。