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Associations of placental weight with maternal and cord blood hormones
Lagiou, Pagona1,2; Hsieh, Chung-Cheng1,3; Samoli, Evangelia2; Lagiou, Areti4; Xu, Biao5; Yu, Guo-Pei6; Onoyama, Sagano3; Chie, Lucy7; Vatten, Lars J.8; Adami, Hans-Olov1,9; Trichopoulos, Dimitrios1; Williams, Michelle A.1
关键词Placenta Intrauterine growth Insulin-like growth factor Hormones
刊名ANNALS OF EPIDEMIOLOGY
2013-11-01
DOI10.1016/j.annepidem.2013.08.003
23期:11页:669-673
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health
研究领域[WOS]Public, Environmental & Occupational Health
关键词[WOS]IGF-BINDING PROTEINS-1 ; GROWTH-FACTOR-I ; BREAST-CANCER ; FETAL-GROWTH ; FETOPLACENTAL GROWTH ; ENDOCRINE REGULATION ; UNITED-STATES ; INSULIN ; CHINA ; SERUM
英文摘要

Purpose: Placental weight has been associated with mammographic pattern and coronary heart disease in the adult offspring, but the mechanisms are unknown. We evaluated the associations of maternal and cord blood hormones with placental weight in normal pregnancies.

Methods: Prospective study of 167 normal singleton pregnancies in Boston, USA and 256 in Shanghai, China. Maternal hormone levels at the 27th gestational week were available for all pregnancies. Cord blood measurements were available for 86 pregnancies in Boston and 104 in Shanghai. Pearson partial correlation coefficients of log-transformed hormone levels with placental weight were calculated.

Results: Maternal levels of estriol, testosterone, and progesterone (P < .05) were positively associated with placental weight. There was no such evidence for adiponectin, prolactin, and insulin-like growth factor (IGF)-I. Cord blood steroids tended to be inversely associated with placental weight, the results being statistically significant for testosterone (P < .05). There was a marginally significant positive association of cord blood IGF-I with placental weight. Reported results were adjusted for study center.

Conclusions: Placental weight appears to be positively correlated with maternal steroids. Its correlation with cord blood steroids, however, appears inverse, compatible with negative feedback mechanisms. There is also a suggestion for placental weight to be positively associated with cord blood IGF-I. (C) 2013 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000326137000001
项目编号CA54220 ; W81XWH-05-1-0314
资助机构National Cancer Institute/National Institutes of Health ; US Department of Defence Breast Cancer Research Program, Office of the Congressionally Directed Medical Research Programs
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61775
专题北京大学医学信息学中心
作者单位1.Athens Technol Educ Inst, Fac Hlth Profess, Athens, Greece
2.Peking Univ, Med Informat Ctr, Beijing 100871, Peoples R China
3.Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
4.Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece
5.Univ Massachusetts, Sch Med, Dept Canc Biol, Worcester, MA USA
6.Fudan Univ, Sch Publ Hlth, Dept Epidemiol, Shanghai 200433, Peoples R China
7.Beth Israel Deaconess Med Ctr, Dept Obstet & Gynecol, Boston, MA 02215 USA
8.Norwegian Univ Sci & Technol, Dept Community Med & Gen Practice, Sch Med, N-7034 Trondheim, Norway
9.Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
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GB/T 7714
Lagiou, Pagona,Hsieh, Chung-Cheng,Samoli, Evangelia,et al. Associations of placental weight with maternal and cord blood hormones[J]. ANNALS OF EPIDEMIOLOGY,2013,23(11):669-673.
APA Lagiou, Pagona.,Hsieh, Chung-Cheng.,Samoli, Evangelia.,Lagiou, Areti.,Xu, Biao.,...&Williams, Michelle A..(2013).Associations of placental weight with maternal and cord blood hormones.ANNALS OF EPIDEMIOLOGY,23(11),669-673.
MLA Lagiou, Pagona,et al."Associations of placental weight with maternal and cord blood hormones".ANNALS OF EPIDEMIOLOGY 23.11(2013):669-673.
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