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学科主题基础医学
Taurine drinking attenuates the burden of intestinal adult worms and muscle larvae in mice with Trichinella spiralis infection
Yu, Yan-Rong1; Liu, Xi-Cheng2; Zhang, Jin-Sheng1; Ji, Chao-Yue1; Qi, Yong-Fen1,3,4
刊名PARASITOLOGY RESEARCH
2013-10-01
DOI10.1007/s00436-013-3525-x
112期:10页:3457-3463
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Parasitology
研究领域[WOS]Parasitology
关键词[WOS]GOBLET CELL HYPERPLASIA ; NEMATODE INFECTION ; MAST-CELL ; EXPERIMENTAL COLITIS ; HELMINTH INFECTION ; EXPULSION ; EPITHELIUM ; MODEL ; MECHANISMS ; EFFECTORS
英文摘要

The parasitic nematode Trichinella spiralis can cause trichinellosis, which leads to pathological processes in the intestine and muscle. The intestinal invasion determines the development, subsequent course, and consequences of the disease. Gastrointestinal nematode infection, including with T. spiralis, is accompanied by a rapid and reversible expansion of mucosal mast cell and goblet cell in the intestinal epithelium, which play important roles in the host immune response to parasite and worm expulsion from the intestine. Taurine and its derivatives have anti-infection and anti-inflammatory properties. We investigated whether taurine supplementation in mice could influence the development and pathological processes of infection with T. spiralis. Supplementing 1 % taurine in drinking water in mice infected with T. spiralis could alleviate the burden of intestinal adult worms on days 7 and 10 postinfection (all p < 0.01) and the formation of infective muscle larvae in striated muscle during T. spiralis infection (p < 0.01). As compared with T. spiralis infection alone, taurine treatment increased the number of goblet cells on days 7, 10, and 15 (p < 0.01 and p < 0.05) and alleviated intestinal mucosal mast cell hyperplasia on days 10 and 15 (all p < 0.01). So taurine supplementation in drinking water increased infection-induced intestinal goblet cell hyperplasia and ameliorated mucosal mastocytosis. Thus, taurine can ameliorate the pathological processes of trichinellosis and may be of great value for the treatment and prevention of infection with T. spiralis and other gastrointestinal nematodes.

语种英语
WOS记录号WOS:000324326500009
项目编号30901247 ; 201110039
资助机构National Natural Science Foundation of China ; National Quality Inspection Public welfare Scientific Research Project ; Leading Academic Discipline Project of Beijing Education Bureau
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61777
专题北京大学基础医学院
作者单位1.Natl Inst Biol Sci, Beijing 102206, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pathogen Biol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Cardiovasc Bioact Mol, Beijing 100191, Peoples R China
4.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
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GB/T 7714
Yu, Yan-Rong,Liu, Xi-Cheng,Zhang, Jin-Sheng,et al. Taurine drinking attenuates the burden of intestinal adult worms and muscle larvae in mice with Trichinella spiralis infection[J]. PARASITOLOGY RESEARCH,2013,112(10):3457-3463.
APA Yu, Yan-Rong,Liu, Xi-Cheng,Zhang, Jin-Sheng,Ji, Chao-Yue,&Qi, Yong-Fen.(2013).Taurine drinking attenuates the burden of intestinal adult worms and muscle larvae in mice with Trichinella spiralis infection.PARASITOLOGY RESEARCH,112(10),3457-3463.
MLA Yu, Yan-Rong,et al."Taurine drinking attenuates the burden of intestinal adult worms and muscle larvae in mice with Trichinella spiralis infection".PARASITOLOGY RESEARCH 112.10(2013):3457-3463.
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