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学科主题: 基础医学
题名:
Taurine drinking attenuates the burden of intestinal adult worms and muscle larvae in mice with Trichinella spiralis infection
作者: Yu, Yan-Rong1; Liu, Xi-Cheng2; Zhang, Jin-Sheng1; Ji, Chao-Yue1; Qi, Yong-Fen1,3,4
刊名: PARASITOLOGY RESEARCH
发表日期: 2013-10-01
DOI: 10.1007/s00436-013-3525-x
卷: 112, 期:10, 页:3457-3463
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Parasitology
研究领域[WOS]: Parasitology
关键词[WOS]: GOBLET CELL HYPERPLASIA ; NEMATODE INFECTION ; MAST-CELL ; EXPERIMENTAL COLITIS ; HELMINTH INFECTION ; EXPULSION ; EPITHELIUM ; MODEL ; MECHANISMS ; EFFECTORS
英文摘要:

The parasitic nematode Trichinella spiralis can cause trichinellosis, which leads to pathological processes in the intestine and muscle. The intestinal invasion determines the development, subsequent course, and consequences of the disease. Gastrointestinal nematode infection, including with T. spiralis, is accompanied by a rapid and reversible expansion of mucosal mast cell and goblet cell in the intestinal epithelium, which play important roles in the host immune response to parasite and worm expulsion from the intestine. Taurine and its derivatives have anti-infection and anti-inflammatory properties. We investigated whether taurine supplementation in mice could influence the development and pathological processes of infection with T. spiralis. Supplementing 1 % taurine in drinking water in mice infected with T. spiralis could alleviate the burden of intestinal adult worms on days 7 and 10 postinfection (all p < 0.01) and the formation of infective muscle larvae in striated muscle during T. spiralis infection (p < 0.01). As compared with T. spiralis infection alone, taurine treatment increased the number of goblet cells on days 7, 10, and 15 (p < 0.01 and p < 0.05) and alleviated intestinal mucosal mast cell hyperplasia on days 10 and 15 (all p < 0.01). So taurine supplementation in drinking water increased infection-induced intestinal goblet cell hyperplasia and ameliorated mucosal mastocytosis. Thus, taurine can ameliorate the pathological processes of trichinellosis and may be of great value for the treatment and prevention of infection with T. spiralis and other gastrointestinal nematodes.

语种: 英语
所属项目编号: 30901247 ; 201110039
项目资助者: National Natural Science Foundation of China ; National Quality Inspection Public welfare Scientific Research Project ; Leading Academic Discipline Project of Beijing Education Bureau
WOS记录号: WOS:000324326500009
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61777
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Natl Inst Biol Sci, Beijing 102206, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pathogen Biol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Cardiovasc Bioact Mol, Beijing 100191, Peoples R China
4.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China

Recommended Citation:
Yu, Yan-Rong,Liu, Xi-Cheng,Zhang, Jin-Sheng,et al. Taurine drinking attenuates the burden of intestinal adult worms and muscle larvae in mice with Trichinella spiralis infection[J]. PARASITOLOGY RESEARCH,2013,112(10):3457-3463.
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