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Acute metabolic crisis induced by vaccination in seven Chinese patients
Yang, Yanling; Sujan, Sayami; Sun, Fang; Zhang, Yuehua; Jiang, Yuwu; Song, Jinqing; Qin, Jiong; Wu, Xiru
刊名PEDIATRIC NEUROLOGY
2006-08-01
DOI10.1016/j.pediatrneurol.2005.12.004
35期:2页:114-118
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Pediatrics
研究领域[WOS]Neurosciences & Neurology ; Pediatrics
关键词[WOS]CONGENITAL ADRENAL-HYPERPLASIA ; ORGANIC ACIDEMIAS ; BRAIN
英文摘要

Seven Chinese patients (5 males and 2 females) with vaccination-induced acute metabolic crisis were reported. Only one male with 21-hydroxylase deficiency had been diagnosed before vaccination. In the remaining six patients, the preexisting diagnoses were not confirmed before the vaccination. Acute metabolic crisis occurred in seven patients between 3 and 12 hours after the administration of Japanese encephalitis, diphtheria, and tetanus toxoids and acellular pertussis, hepatitis B, or measles vaccines. Patients I and 2 displayed acute adrenal insufficiencies at the ages of 5 years and 3 months, respectively. Patient 3 had presented with mild motor retardation previously. Patients 4 to 7 were previously healthy, but suffered from fever, seizures, coma, acidosis, and hypoglycemia after being vaccinated. Glutaric aciduria type 1 was evident in case 4. Leigh syndromes were present in Patients 5, 6, and 7. They all died from respiratory failure before 2 years of age. Symmetric foci, cystic cavitations with neuronal loss, and vascular proliferation were observed by postmortem examination. Among the seven patients, although the vaccines were not the primary cause of the acute metabolic crisis, the severe acute episodes occurred coincidentally. (c) 2006 by Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000239697900006
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61779
专题北京大学第一临床医学院_儿科
作者单位Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
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GB/T 7714
Yang, Yanling,Sujan, Sayami,Sun, Fang,et al. Acute metabolic crisis induced by vaccination in seven Chinese patients[J]. PEDIATRIC NEUROLOGY,2006,35(2):114-118.
APA Yang, Yanling.,Sujan, Sayami.,Sun, Fang.,Zhang, Yuehua.,Jiang, Yuwu.,...&Wu, Xiru.(2006).Acute metabolic crisis induced by vaccination in seven Chinese patients.PEDIATRIC NEUROLOGY,35(2),114-118.
MLA Yang, Yanling,et al."Acute metabolic crisis induced by vaccination in seven Chinese patients".PEDIATRIC NEUROLOGY 35.2(2006):114-118.
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