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学科主题: 临床医学
题名:
Acute metabolic crisis induced by vaccination in seven Chinese patients
作者: Yang, Yanling; Sujan, Sayami; Sun, Fang; Zhang, Yuehua; Jiang, Yuwu; Song, Jinqing; Qin, Jiong; Wu, Xiru
刊名: PEDIATRIC NEUROLOGY
发表日期: 2006-08-01
DOI: 10.1016/j.pediatrneurol.2005.12.004
卷: 35, 期:2, 页:114-118
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Pediatrics
研究领域[WOS]: Neurosciences & Neurology ; Pediatrics
关键词[WOS]: CONGENITAL ADRENAL-HYPERPLASIA ; ORGANIC ACIDEMIAS ; BRAIN
英文摘要:

Seven Chinese patients (5 males and 2 females) with vaccination-induced acute metabolic crisis were reported. Only one male with 21-hydroxylase deficiency had been diagnosed before vaccination. In the remaining six patients, the preexisting diagnoses were not confirmed before the vaccination. Acute metabolic crisis occurred in seven patients between 3 and 12 hours after the administration of Japanese encephalitis, diphtheria, and tetanus toxoids and acellular pertussis, hepatitis B, or measles vaccines. Patients I and 2 displayed acute adrenal insufficiencies at the ages of 5 years and 3 months, respectively. Patient 3 had presented with mild motor retardation previously. Patients 4 to 7 were previously healthy, but suffered from fever, seizures, coma, acidosis, and hypoglycemia after being vaccinated. Glutaric aciduria type 1 was evident in case 4. Leigh syndromes were present in Patients 5, 6, and 7. They all died from respiratory failure before 2 years of age. Symmetric foci, cystic cavitations with neuronal loss, and vascular proliferation were observed by postmortem examination. Among the seven patients, although the vaccines were not the primary cause of the acute metabolic crisis, the severe acute episodes occurred coincidentally. (c) 2006 by Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000239697900006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61779
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China

Recommended Citation:
Yang, Yanling,Sujan, Sayami,Sun, Fang,et al. Acute metabolic crisis induced by vaccination in seven Chinese patients[J]. PEDIATRIC NEUROLOGY,2006,35(2):114-118.
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