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Reference Values for Amplitude-Integrated EEGs in Infants From Preterm to 3.5 Months of Age
Zhang, Dandan1,2; Liu, Yunfeng2; Hou, Xinlin3; Zhou, Congle3; Luo, Yuejia1; Ye, Datian2; Ding, Haiyan1
关键词amplitude-integrated EEG infant reference values upper and lower margins
刊名PEDIATRICS
2011-05-01
DOI10.1542/peds.2010-2833
127期:5页:E1280-E1287
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pediatrics
资助者Tsinghua-Yue-Yuen Medical Sciences Fund ; Dr Shun Tak Wu&prime ; s Medical Sciences Fund ; National Science Foundation ; Chinese Ministry of Education Foundation ; Tsinghua-Yue-Yuen Medical Sciences Fund ; Dr Shun Tak Wu&prime ; s Medical Sciences Fund ; National Science Foundation ; Chinese Ministry of Education Foundation
研究领域[WOS]Pediatrics
关键词[WOS]CEREBRAL FUNCTION MONITOR ; ELECTROENCEPHALOGRAPHIC ACTIVITY ; MATURATION ; NEWBORNS ; TERM ; GESTATION ; PATTERNS ; YOUNGER
英文摘要

OBJECTIVES: Amplitude-integrated electroencephalogram (aEEG) is a valuable tool for the continuous evaluation of functional brain maturation in infants. The amplitudes of the upper and lower margins of aEEGs are postulated to change with maturation and correlate with postmenstrual age (PMA). In this study we aimed to establish reliable reference values of aEEG amplitudes, which provide quantitative guidelines for assessing brain maturation as indicated by aEEG results in neonates and young infants.

METHODS: aEEGs from healthy infants (n = 274) with PMAs that ranged from 30 to 55 weeks were divided into 10 groups according to their PMAs. Two 5-minute segments were selected from each aEEG and were used to automatically calculate the upper and lower margins and bandwidths of the aEEG tracings.

RESULTS: Interobserver agreement was achieved with an overall correlation of 0.99. The upper and lower margins of the aEEGs in both active and quiet sleep clearly rose in infants after the neonatal period. The bandwidth defined as the graphic distance decreased almost monotonically throughout the PMA range from 30 to 55 weeks. The lower margin of the aEEG was positively correlated with PMA, with a larger rank correlation coefficient during quiet sleep (r = 0.89) than during active sleep (r = 0.49).

CONCLUSIONS: Reference values of aEEG amplitudes were obtained for infants with a wide range of PMAs and constituted the basis for the quantitative assessment of aEEG changes with maturation in neonates and young infants. The normative amplitudes of aEEG margins, especially of the lower margin in quiet sleep, are recommended as a source of reference data for the identification of potentially abnormal aEEG results. Pediatrics 2011;127:e1280-e1287

语种英语
所属项目编号20080430380 ; 200800011071
资助者Tsinghua-Yue-Yuen Medical Sciences Fund ; Dr Shun Tak Wu&prime ; s Medical Sciences Fund ; National Science Foundation ; Chinese Ministry of Education Foundation ; Tsinghua-Yue-Yuen Medical Sciences Fund ; Dr Shun Tak Wu&prime ; s Medical Sciences Fund ; National Science Foundation ; Chinese Ministry of Education Foundation
WOS记录号WOS:000290097800023
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61780
专题北京大学第一临床医学院_儿科
作者单位1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
2.Tsinghua Univ, Dept Biomed Engn, Beijing 100084, Peoples R China
3.Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Dandan,Liu, Yunfeng,Hou, Xinlin,et al. Reference Values for Amplitude-Integrated EEGs in Infants From Preterm to 3.5 Months of Age[J]. PEDIATRICS,2011,127(5):E1280-E1287.
APA Zhang, Dandan.,Liu, Yunfeng.,Hou, Xinlin.,Zhou, Congle.,Luo, Yuejia.,...&Ding, Haiyan.(2011).Reference Values for Amplitude-Integrated EEGs in Infants From Preterm to 3.5 Months of Age.PEDIATRICS,127(5),E1280-E1287.
MLA Zhang, Dandan,et al."Reference Values for Amplitude-Integrated EEGs in Infants From Preterm to 3.5 Months of Age".PEDIATRICS 127.5(2011):E1280-E1287.
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