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Biotransformation of 2 alpha,5 alpha,10 beta,14 beta-tetra-acetoxy-4(20), 11-taxadiene by Ginkgo cell suspension cultures
Dai, JG; Guo, HZ; Lu, DD; Zhu, WH; Zhang, DY; Zheng, JH; Guo, D
关键词biotransformation taxane cell suspension cultures Ginkgo biloba
刊名TETRAHEDRON LETTERS
2001-07-09
42期:28页:4677-4679
收录类别IC ; CCR ; SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]TAXUS-CUSPIDATA ; TAXOIDS
英文摘要

Ginkgo biloba cell suspension cultures were used to biotransform 2 alpha ,5 alpha ,10 beta ,14 beta -tetra-acetoxy-4(20),11-taxadiene. Two novel compounds were obtained and their structures were identified as 9 alpha -hydroxyl-2 alpha ,5 alpha ,10 beta ,14 beta -tetra-acetoxy-4(20), 11-taxadiene 1 and 9 alpha, 10 beta -dihydroxyl-2 alpha ,5 alpha ,14 beta -tri-acetoxy-4(20), 11-taxadiene 2, respectively, on the basis of their physical and chemical data. Compound 1 was subsequently used as a substrate for the bioconversion by Ginkgo cell cultures, and the product obtained was confirmed to be the same as 2, which suggested that 2 is biosynthesized From 1. investigation on properties of the related enzymes responsible for the biotransformation reaction through the experimental techniques of cell-free culture and substrate/product concentration analysis revealed that the enzymes were extracellular and constitutive. (C) 2001 Elsevier Science Ltd. All rights reserved.

语种英语
WOS记录号WOS:000169541300021
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61781
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
3.Beijing Union Med Coll, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714
Dai, JG,Guo, HZ,Lu, DD,et al. Biotransformation of 2 alpha,5 alpha,10 beta,14 beta-tetra-acetoxy-4(20), 11-taxadiene by Ginkgo cell suspension cultures[J]. TETRAHEDRON LETTERS,2001,42(28):4677-4679.
APA Dai, JG.,Guo, HZ.,Lu, DD.,Zhu, WH.,Zhang, DY.,...&Guo, D.(2001).Biotransformation of 2 alpha,5 alpha,10 beta,14 beta-tetra-acetoxy-4(20), 11-taxadiene by Ginkgo cell suspension cultures.TETRAHEDRON LETTERS,42(28),4677-4679.
MLA Dai, JG,et al."Biotransformation of 2 alpha,5 alpha,10 beta,14 beta-tetra-acetoxy-4(20), 11-taxadiene by Ginkgo cell suspension cultures".TETRAHEDRON LETTERS 42.28(2001):4677-4679.
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