IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Clinical implications and prognostic value of single and combined biomarkers in endometrial carcinoma
Li Mingzhu; Zhao Lijun; Shen Danhua; Li Xiaoping; Wang Jianliu; Wei Lihui
关键词endometrial carcinoma immunohistochemistry clinical factors biomarkers
刊名CHINESE MEDICAL JOURNAL
2014-04-20
DOI10.3760/cma.j.issn.0366-6999.20132774
127期:8页:1459-1463
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]General & Internal Medicine
关键词[WOS]P53 ; CANCER ; EXPRESSION ; RECEPTOR ; KI-67 ; PTEN ; ANGIOGENESIS ; PROTEIN ; BCL-2 ; KI67
英文摘要

Background Endometrial carcinoma is one of the most common gynecological cancers and the incidence has been increasing. This study was to identify the relationship of estrogen receptor (ER), progestrone receptor (PR), P53 protein, Ki-67 and phosphatase and tensin homolog deleted on chromosome ten (PTEN) with endometrial carcinoma, the assessment of these bionnarkers and their association with clinicopathological parameters was performed.

Methods A total of 198 cases of primary endometrial carcinoma were investigated for ER, PR, Ki-67, P53, and PTEN antigens by immunohistochemical methods. The association of these markers with age, menopause status, histological type, FIGO stage, grading, depth of invasion, lymph node involvement and serum tumor marker was examined.

Results The percentages of Ki-67- and P53-negative endometrial tumors were significantly higher in ER-positive compared with ER-negative tumors (both P=0.000). The same trend was evident with PR status. The percentage of PTEN-positive tumors was significantly higher in PR-positive compared with PR-negative tumors (P=0.021), but was no difference in tumors with different ER status. There was no clear association between PTEN positivity and clinicopathological parameters except more relevance with endometrioid histotype (P=0.013). There was a statistically significant difference in the distribution of the different combined biological factors examined in disease-free survival.

Conclusions ER and PR status were significant predictors with staging, grading and recurrence. P53 and Ki-67 expression were inversely correlated with both ER and PR expression and have more aggressive clinicopathological features. PTEN expression was inversely correlated with PR expression but not with ER expression. The combined type of ER+PR+P53-PTEN+ was in the majority in endometrial cancer and seemed to be related to better clinical outcome. The combination of ER PR P53+PTEN- represented the worst disease-free survival and was strongly associated with

语种英语
所属项目编号81101952
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000335936700013
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61784
Collection北京大学第二临床医学院
作者单位Peking Univ, Dept Obstet & Gynecol, Peoples Hosp, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Li Mingzhu,Zhao Lijun,Shen Danhua,et al. Clinical implications and prognostic value of single and combined biomarkers in endometrial carcinoma[J]. CHINESE MEDICAL JOURNAL,2014,127(8):1459-1463.
APA Li Mingzhu,Zhao Lijun,Shen Danhua,Li Xiaoping,Wang Jianliu,&Wei Lihui.(2014).Clinical implications and prognostic value of single and combined biomarkers in endometrial carcinoma.CHINESE MEDICAL JOURNAL,127(8),1459-1463.
MLA Li Mingzhu,et al."Clinical implications and prognostic value of single and combined biomarkers in endometrial carcinoma".CHINESE MEDICAL JOURNAL 127.8(2014):1459-1463.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Li Mingzhu]'s Articles
[Zhao Lijun]'s Articles
[Shen Danhua]'s Articles
百度学术
百度学术Similar articles in
[Li Mingzhu]'s Articles
[Zhao Lijun]'s Articles
[Shen Danhua]'s Articles
必应学术
必应学术Similar articles in
[Li Mingzhu]'s Articles
[Zhao Lijun]'s Articles
[Shen Danhua]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.