学科主题 | 临床医学 |
Clinical implications and prognostic value of single and combined biomarkers in endometrial carcinoma | |
Li Mingzhu; Zhao Lijun; Shen Danhua; Li Xiaoping; Wang Jianliu; Wei Lihui | |
关键词 | endometrial carcinoma immunohistochemistry clinical factors biomarkers |
刊名 | CHINESE MEDICAL JOURNAL
![]() |
2014-04-20 | |
DOI | 10.3760/cma.j.issn.0366-6999.20132774 |
卷 | 127期:8页:1459-1463 |
收录类别 | SCI |
文章类型 | Article |
WOS标题词 | Science & Technology |
类目[WOS] | Medicine, General & Internal |
资助者 | National Natural Science Foundation of China ; National Natural Science Foundation of China |
研究领域[WOS] | General & Internal Medicine |
关键词[WOS] | P53 ; CANCER ; EXPRESSION ; RECEPTOR ; KI-67 ; PTEN ; ANGIOGENESIS ; PROTEIN ; BCL-2 ; KI67 |
英文摘要 | Background Endometrial carcinoma is one of the most common gynecological cancers and the incidence has been increasing. This study was to identify the relationship of estrogen receptor (ER), progestrone receptor (PR), P53 protein, Ki-67 and phosphatase and tensin homolog deleted on chromosome ten (PTEN) with endometrial carcinoma, the assessment of these bionnarkers and their association with clinicopathological parameters was performed. Methods A total of 198 cases of primary endometrial carcinoma were investigated for ER, PR, Ki-67, P53, and PTEN antigens by immunohistochemical methods. The association of these markers with age, menopause status, histological type, FIGO stage, grading, depth of invasion, lymph node involvement and serum tumor marker was examined. Results The percentages of Ki-67- and P53-negative endometrial tumors were significantly higher in ER-positive compared with ER-negative tumors (both P=0.000). The same trend was evident with PR status. The percentage of PTEN-positive tumors was significantly higher in PR-positive compared with PR-negative tumors (P=0.021), but was no difference in tumors with different ER status. There was no clear association between PTEN positivity and clinicopathological parameters except more relevance with endometrioid histotype (P=0.013). There was a statistically significant difference in the distribution of the different combined biological factors examined in disease-free survival. Conclusions ER and PR status were significant predictors with staging, grading and recurrence. P53 and Ki-67 expression were inversely correlated with both ER and PR expression and have more aggressive clinicopathological features. PTEN expression was inversely correlated with PR expression but not with ER expression. The combined type of ER+PR+P53-PTEN+ was in the majority in endometrial cancer and seemed to be related to better clinical outcome. The combination of ER PR P53+PTEN- represented the worst disease-free survival and was strongly associated with |
语种 | 英语 |
所属项目编号 | 81101952 |
资助者 | National Natural Science Foundation of China ; National Natural Science Foundation of China |
WOS记录号 | WOS:000335936700013 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/61784 |
Collection | 北京大学第二临床医学院 |
作者单位 | Peking Univ, Dept Obstet & Gynecol, Peoples Hosp, Beijing 100044, Peoples R China |
Recommended Citation GB/T 7714 | Li Mingzhu,Zhao Lijun,Shen Danhua,et al. Clinical implications and prognostic value of single and combined biomarkers in endometrial carcinoma[J]. CHINESE MEDICAL JOURNAL,2014,127(8):1459-1463. |
APA | Li Mingzhu,Zhao Lijun,Shen Danhua,Li Xiaoping,Wang Jianliu,&Wei Lihui.(2014).Clinical implications and prognostic value of single and combined biomarkers in endometrial carcinoma.CHINESE MEDICAL JOURNAL,127(8),1459-1463. |
MLA | Li Mingzhu,et al."Clinical implications and prognostic value of single and combined biomarkers in endometrial carcinoma".CHINESE MEDICAL JOURNAL 127.8(2014):1459-1463. |
Files in This Item: | There are no files associated with this item. |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment