|Changes of vasoactive polypeptides during postoperative hypertensive crisis in patients with hypertensive intracerebral hemorrhage|
|Wang Zhi1; Wang Xue-feng1; Wang Chao1; Luan Wen-zhong2|
|关键词||hypertensive intracerebral hemorrhage hypertensive crisis vasoactive polypeptide|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
Background Hypertensive crisis could be found after operation in patients with hypertensive intracerebral hemorrhage (HICH). The aim of this study was to explore the changes and the roles of some vasoactive polypeptides during postoperative hypertensive crisis in patients with HICH.
Methods A total of 31 patients, who were admitted for craniotomy, were enrolled into this study. After the operation, the patients were divided into three groups. Group I consisted of 9 patients with postoperative hypertensive crisis, and group II was composed of 13 patients without postoperative hypertensive crisis. Nine patients, who denied history of hypertension or HICH, were set as group III. The levels of some vasoactivators in the three groups were measured before and after the operation. The differences in the results among the groups were analyzed using the ANOVA. The data collected before and after the operation in the group I was compared by Wilcoxon test.
Results The concentration of endothelin in group I was significantly higher than that in group III (P < 0.05). The level of thromboxane A2 and the ratio of thromboxane B2 to 6-keto-PGF1 alpha in group I were significantly higher than those in the other two groups (P < 0.05). In group I, the levels of plasma renin activity, angiotensin II, aldosterone, catecholamine, andendothelin before the operation were significantly higher than those determined after the operation (P > 0.05).
Conclusions Postoperative hypertensive crisis maybe due to the increased thromboxane A2 and relatively inadequate prostacyclin, especially 6-keto-PGF1 alpha. The increased level of endothelin and intraoperative stimulation also play a certain role in the development of postoperative hypertensive crisis.
|作者单位||1.Harbin Med Coll, Fourth Affiliated Hosp, Dept Neurosurg, Harbin 150001, Peoples R China|
2.Peking Univ, Peoples Hosp, Dept Neurosurg, Beijing 100044, Peoples R China
|Wang Zhi,Wang Xue-feng,Wang Chao,et al. Changes of vasoactive polypeptides during postoperative hypertensive crisis in patients with hypertensive intracerebral hemorrhage[J]. CHINESE MEDICAL JOURNAL,2007,120(23):2129-2131.|
|APA||Wang Zhi,Wang Xue-feng,Wang Chao,&Luan Wen-zhong.(2007).Changes of vasoactive polypeptides during postoperative hypertensive crisis in patients with hypertensive intracerebral hemorrhage.CHINESE MEDICAL JOURNAL,120(23),2129-2131.|
|MLA||Wang Zhi,et al."Changes of vasoactive polypeptides during postoperative hypertensive crisis in patients with hypertensive intracerebral hemorrhage".CHINESE MEDICAL JOURNAL 120.23(2007):2129-2131.|