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IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Effects of atorvastatin loading prior to primary percutaneous coronary intervention on endothelial function and inflammatory factors in patients with ST-segment elevation myocardial infarction
作者: Yong, Huijuan1; Wang, Xin1; Mi, Lin1,2,3; Guo, Lijun1,2,3; Gao, Wei1,2,3; Zhang, Yongzhen1,2,3; Cui, Ming1,2,3
关键词: primary percutaneous coronary intervention ; atorvastatin ; endothelial function ; inflammatory reaction ; ST-segment elevation myocardial infarction
刊名: EXPERIMENTAL AND THERAPEUTIC MEDICINE
发表日期: 2014-02-01
DOI: 10.3892/etm.2013.1432
卷: 7, 期:2, 页:316-322
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: CHRONIC STATIN THERAPY ; C-REACTIVE PROTEIN ; NITRIC-OXIDE ; RANDOMIZED-TRIAL ; PRETREATMENT ; REDUCTION ; ANGIOPLASTY ; DAMAGE ; ADHESION ; DISEASE
英文摘要:

Previous studies have demonstrated the beneficial effect of statin loading prior to elective and early percutaneous coronary intervention (PCI), in which the ′pleiotropic effects′ of statins may contribute to these clinical benefits. The aim of the present study was to examine the potential effects of atorvastatin loading prior to primary PCI on coronary endothelial function and inflammatory factors in patients with acute ST-segment elevation myocardial infarction (STEMI). A total of 60 patients with STEMI were randomized into three groups: Loading dose (80 mg atorvastatin prior to PCI; n=20), regular dose (20 mg atorvastatin prior to PCI; n=20) and control (without atorvastatin prior to PCI; n=20). The plasma samples were collected prior to, and immediately, 6 and 24 h after PCI in all the patients. The plasma concentrations of endothelial nitric oxide synthase (eNOS), nitric oxide (NO), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 (ICAM-1) were examined using ELISA. The plasma eNOS levels immediately and 24 h after PCI were significantly higher in the regular dose group compared with the other groups. However, there were no significant differences in the plasma eNOS concentration prior to and 6 h after PCI, or in the plasma NO concentration at any of the time-points among the three groups. The plasma IL-6 levels prior to PCI were significantly lower in the loading dose group compared with the other groups; however, there were no significant differences in the plasma concentration of IL-6 following PCI or in the concentrations of TNF-alpha and ICAM-1 at any of the time-points among the three groups. In conclusion, atorvastatin loading in patients with STEMI undergoing primary PCI may not have protective effects on endothelial function and the inflammatory reaction.

语种: 英语
所属项目编号: 81070260 ; 31070948 ; 7102099 ; 7122200
项目资助者: National Natural Sciences Grant of China ; Beijing Natural Sciences Grant
WOS记录号: WOS:000332690900002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61787
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Dept Cardiol, Hosp 3, Beijing 100191, Peoples R China
3.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing 100191, Peoples R China

Recommended Citation:
Yong, Huijuan,Wang, Xin,Mi, Lin,et al. Effects of atorvastatin loading prior to primary percutaneous coronary intervention on endothelial function and inflammatory factors in patients with ST-segment elevation myocardial infarction[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2014,7(2):316-322.
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