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Effects of pH-sensitive nanoparticles prepared with different polymers on the distribution, adhesion and transition of Rhodamine 6G in the gut of rats
Wu, Cui-shuan1; Wang, Xue-qing1; Meng, Meng1; Li, Ming-guang1; Zhang, Hua1; Zhang, Xuan1; Wang, Jian-cheng1; Wu, Tao2; Nie, Wen-hui2; Zhang, Qiang1
关键词Distribution transition adhesion pH-sensitive nanoparticles gastrointestinal tract enteric polymers
刊名JOURNAL OF MICROENCAPSULATION
2010-05-01
DOI10.3109/02652040903059163
27期:3页:205-217
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Engineering, Chemical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Engineering ; Pharmacology & Pharmacy
关键词[WOS]IN-VIVO EVALUATION ; CYCLOSPORINE-A ; GASTROINTESTINAL-TRACT ; ORAL BIOAVAILABILITY ; PARTICLE-SIZE ; DOSAGE FORMS ; DRUG-RELEASE ; MICROSPHERES ; ABSORPTION ; DELIVERY
英文摘要

To investigate the effect of different enteric polymers on the characteristics of pH-sensitive nanoparticles, Rhodamine 6G (Rho) was incorporated in various pH-sensitive nanoparticles. The different patterns of pH-dependent release profiles were observed, although some polymers have the same dissolving pH. The distribution, adhesion and transition of different nanoparticles in rat gut showed significant difference, closely related to the release characteristics of nanoparticles, and their release behaviour are dependent on the dissolving pH and the structure of the polymers, as well as the drug property. Most nanoparticle formulations decreased the distribution and adhesion of Rho in the stomach but increased these values in the intestine. The nanocarriers also control the drug release sites and release rate in the GI tract. In conclusion, pH-sensitive nanoparticles seem favourable for drug absorption and it is important to choose the proper materials to obtain the suitable characteristics for the oral pH-sensitive nanoparticles.

语种英语
WOS记录号WOS:000276867000003
项目编号2009CB930300 ; 2007 AA021811
资助机构Ministry of Science and Technology
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61789
专题北京大学药学院
作者单位1.Beijing Double Crane Pharmaceut Co Ltd, Beijing, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wu, Cui-shuan,Wang, Xue-qing,Meng, Meng,et al. Effects of pH-sensitive nanoparticles prepared with different polymers on the distribution, adhesion and transition of Rhodamine 6G in the gut of rats[J]. JOURNAL OF MICROENCAPSULATION,2010,27(3):205-217.
APA Wu, Cui-shuan.,Wang, Xue-qing.,Meng, Meng.,Li, Ming-guang.,Zhang, Hua.,...&Zhang, Qiang.(2010).Effects of pH-sensitive nanoparticles prepared with different polymers on the distribution, adhesion and transition of Rhodamine 6G in the gut of rats.JOURNAL OF MICROENCAPSULATION,27(3),205-217.
MLA Wu, Cui-shuan,et al."Effects of pH-sensitive nanoparticles prepared with different polymers on the distribution, adhesion and transition of Rhodamine 6G in the gut of rats".JOURNAL OF MICROENCAPSULATION 27.3(2010):205-217.
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