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学科主题: 药学
题名:
Effects of pH-sensitive nanoparticles prepared with different polymers on the distribution, adhesion and transition of Rhodamine 6G in the gut of rats
作者: Wu, Cui-shuan1; Wang, Xue-qing1; Meng, Meng1; Li, Ming-guang1; Zhang, Hua1; Zhang, Xuan1; Wang, Jian-cheng1; Wu, Tao2; Nie, Wen-hui2; Zhang, Qiang1
关键词: Distribution ; transition ; adhesion ; pH-sensitive nanoparticles ; gastrointestinal tract ; enteric polymers
刊名: JOURNAL OF MICROENCAPSULATION
发表日期: 2010-05-01
DOI: 10.3109/02652040903059163
卷: 27, 期:3, 页:205-217
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied ; Engineering, Chemical ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Engineering ; Pharmacology & Pharmacy
关键词[WOS]: IN-VIVO EVALUATION ; CYCLOSPORINE-A ; GASTROINTESTINAL-TRACT ; ORAL BIOAVAILABILITY ; PARTICLE-SIZE ; DOSAGE FORMS ; DRUG-RELEASE ; MICROSPHERES ; ABSORPTION ; DELIVERY
英文摘要:

To investigate the effect of different enteric polymers on the characteristics of pH-sensitive nanoparticles, Rhodamine 6G (Rho) was incorporated in various pH-sensitive nanoparticles. The different patterns of pH-dependent release profiles were observed, although some polymers have the same dissolving pH. The distribution, adhesion and transition of different nanoparticles in rat gut showed significant difference, closely related to the release characteristics of nanoparticles, and their release behaviour are dependent on the dissolving pH and the structure of the polymers, as well as the drug property. Most nanoparticle formulations decreased the distribution and adhesion of Rho in the stomach but increased these values in the intestine. The nanocarriers also control the drug release sites and release rate in the GI tract. In conclusion, pH-sensitive nanoparticles seem favourable for drug absorption and it is important to choose the proper materials to obtain the suitable characteristics for the oral pH-sensitive nanoparticles.

语种: 英语
所属项目编号: 2009CB930300 ; 2007 AA021811
项目资助者: Ministry of Science and Technology
WOS记录号: WOS:000276867000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61789
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Beijing Double Crane Pharmaceut Co Ltd, Beijing, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Wu, Cui-shuan,Wang, Xue-qing,Meng, Meng,et al. Effects of pH-sensitive nanoparticles prepared with different polymers on the distribution, adhesion and transition of Rhodamine 6G in the gut of rats[J]. JOURNAL OF MICROENCAPSULATION,2010,27(3):205-217.
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