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学科主题: 临床医学
题名:
Efficacy and Safety of Micafungin as Prophylaxis for Invasive Fungal Disease in Neutropenic Patients with Hematologic Malignancies
作者: Wan, Liping1; Wang, Chun1; Liu, Lin2; Tang, Xiaoqiong2; Wang, Jinghua3; Guan, Yue3; Jiang, Ming4; Duan, Xianlin4; Ke, Xiaoyan5; Jing, Hongmei5; Hu, Jiong6; Wang, Ling6; Li, Yuming7; Geng, Li7
关键词: Micafungin ; invasive fungal disease ; neutropenia ; hematologic malignancy ; prophylaxis
刊名: INTERNATIONAL JOURNAL OF PHARMACOLOGY
发表日期: 2014-05-15
DOI: 10.3923/ijp.2014.231.236
卷: 10, 期:4, 页:231-236
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: STEM-CELL TRANSPLANTATION ; ANTIFUNGAL PROPHYLAXIS ; INFECTIONS ; EPIDEMIOLOGY ; FLUCONAZOLE ; REGIMENS
英文摘要:

Invasive Fungal Disease (IFD) is a major cause of death in severe neutropenic patients with hematologic malignancies. Micafungin, a new echinocandin antifungal drug, is effective in treating IFD. However, the efficacy and safety of micafungin in preventing IFD in severe neutropenic patients with hematologic malignancies have not been demonstrated. A prospective and multicenter clinical study was conducted to evaluate the efficacy and safety of micafungin as prophylaxis for IFD. Micafungin 50 mg daily was administered intravenously to 117 high-risk patients with hematologic malignancies undergoing intensive chemotherapy or Hematopoietic Stem Cell Transplantation (HSCT), for a median of 24 days. Successful prophylaxis (no proven, probable or possible IFD up to 1 week after the end of prophylactic treatment) was achieved in 88.54% patients. No patient developed proven IFD during treatment and only 2.08% had probable IFD and 9.38% possible IFD. Micafungin potentially accounted for adverse events in 6.84% of patients. No severe adverse events attributable to micafungin were seen. Micafungin 50 mg daily is a promising prophylactic antifungal therapy for neutropenic patients with hematologic malignancies.

语种: 英语
WOS记录号: WOS:000343950200006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61796
Appears in Collections:北京大学第三临床医学院_血液内科_期刊论文

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作者单位: 1.Tianjin First Cent Hosp, Dept Hematol, Tianjin, Peoples R China
2.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 1, Dept Hematol, Shanghai 200080, Peoples R China
3.Chongqing Med Univ, Affiliated Hosp 1, Dept Hematol, Chongqing, Peoples R China
4.Harbin Med Univ, Affiliated Hosp 2, Dept Hematol, Harbin, Peoples R China
5.Xinjiang Med Univ, Hematol Dis Ctr, Affiliated Hosp 1, Xinjiang, Peoples R China
6.Beijing Med Univ, Dept Hematol, Affiliated Hosp 3, Beijing 100083, Peoples R China
7.Shanghai Jiao Tong Univ, Affiliated Ruijin Hosp, Dept Hematol, Shanghai 200080, Peoples R China

Recommended Citation:
Wan, Liping,Wang, Chun,Liu, Lin,et al. Efficacy and Safety of Micafungin as Prophylaxis for Invasive Fungal Disease in Neutropenic Patients with Hematologic Malignancies[J]. INTERNATIONAL JOURNAL OF PHARMACOLOGY,2014,10(4):231-236.
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