|Differential diagnosis of pulmonary lesions by parametric imaging in F-18-FDG PET/CT dynamic multi-bed scanning|
|Wang, Qiang1; Wang, Rong-fu1; Jianhua-Zhang1; Zhou, Yun2|
|关键词||cancer diagnosis F-18-FDG PET/CT parametric imaging pulmonary lesions|
|刊名||JOURNAL OF BUON|
|WOS标题词||Science & Technology|
|关键词[WOS]||CELL LUNG-CANCER ; TUMOR GLUCOSE-METABOLISM ; FDG-PET ; INPUT FUNCTION ; QUANTIFICATION ; IMAGES ; MANAGEMENT ; MODEL ; CT|
Purpose: Benign and malignant pulmonary lesions are not easy to distinguish in a clinical setting. We investigated the feasibility of using parametric imaging of the rate constant Ki to diagnose the nature of pulmonary lesions.
Methods: Dynamic multi-bed scanning followed by a routine examination was performed on 21 patients with pulmonary lesions who were divided into two groups with malignant or benign lesions based on biopsy and follow-up. The number of patients in the malignant and benign groups were 10 with 15 lesions and 11 with 14 lesions, respectively. The left ventricular blood pool was used for an image-derived input function. The influx rate constant Ki of the pulmonary lesions and parametric images was generated with the Patlak plot method, and the inter-group differences for Ki, maximum standardized uptake value (SUVmax), and the time-activity curves (TAC) of fluorine-18-fludeoxyglucose (F-18-FDG) were analyzed. At the same time, we investigated the correlation of Ki to SUVmax.
Results: The maximum diameters of the pulmonary lesions were not significantly different between the malignant and benign groups (p>0.05). Ki and SUVmax were significantly higher in malignant lesions compared to benign lesions (p<0.05). Ki was highly correlated with SUVmax in pulmonary lesions (r=0.815, p<0.01). The malignant lesions showed gradually increasing TAC, and benign lesions exhibited gradually decreasing curves. The parametric images of Ki were useful to distinguish malignant lesions from normal tissue.
Conclusion: Our results indicate that Ki parametric imaging in F-18-FDG PET/computed tomography (CT) dynamic multi-bed scanning may be useful in the differential diagnosis of pulmonary lesions.
|项目编号||NSFC 81071183 ; 2011YQ030114 ; 2011YQ03011409 ; BMU20120297 ; 110204 ; 120121|
|资助机构||Natural Science Foundation of China ; Ministry of Science and Technology of China ; Research Fund for the Medicine and Engineering of Peking University ; Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, Department of Chemistry, Beijing Normal University, Beijing, China|
|作者单位||1.Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100871, Peoples R China|
2.Johns Hopkins Univ, Sch Med, Dept Radiol & Radiol Sci, Baltimore, MD USA
|Wang, Qiang,Wang, Rong-fu,Jianhua-Zhang,et al. Differential diagnosis of pulmonary lesions by parametric imaging in F-18-FDG PET/CT dynamic multi-bed scanning[J]. JOURNAL OF BUON,2013,18(4):928-934.|
|APA||Wang, Qiang,Wang, Rong-fu,Jianhua-Zhang,&Zhou, Yun.(2013).Differential diagnosis of pulmonary lesions by parametric imaging in F-18-FDG PET/CT dynamic multi-bed scanning.JOURNAL OF BUON,18(4),928-934.|
|MLA||Wang, Qiang,et al."Differential diagnosis of pulmonary lesions by parametric imaging in F-18-FDG PET/CT dynamic multi-bed scanning".JOURNAL OF BUON 18.4(2013):928-934.|