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学科主题: 临床医学
题名:
Differential diagnosis of pulmonary lesions by parametric imaging in F-18-FDG PET/CT dynamic multi-bed scanning
作者: Wang, Qiang1; Wang, Rong-fu1; Jianhua-Zhang1; Zhou, Yun2
关键词: cancer ; diagnosis ; F-18-FDG PET/CT ; parametric imaging ; pulmonary lesions
刊名: JOURNAL OF BUON
发表日期: 2013-10-01
卷: 18, 期:4, 页:928-934
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CELL LUNG-CANCER ; TUMOR GLUCOSE-METABOLISM ; FDG-PET ; INPUT FUNCTION ; QUANTIFICATION ; IMAGES ; MANAGEMENT ; MODEL ; CT
英文摘要:

Purpose: Benign and malignant pulmonary lesions are not easy to distinguish in a clinical setting. We investigated the feasibility of using parametric imaging of the rate constant Ki to diagnose the nature of pulmonary lesions.

Methods: Dynamic multi-bed scanning followed by a routine examination was performed on 21 patients with pulmonary lesions who were divided into two groups with malignant or benign lesions based on biopsy and follow-up. The number of patients in the malignant and benign groups were 10 with 15 lesions and 11 with 14 lesions, respectively. The left ventricular blood pool was used for an image-derived input function. The influx rate constant Ki of the pulmonary lesions and parametric images was generated with the Patlak plot method, and the inter-group differences for Ki, maximum standardized uptake value (SUVmax), and the time-activity curves (TAC) of fluorine-18-fludeoxyglucose (F-18-FDG) were analyzed. At the same time, we investigated the correlation of Ki to SUVmax.

Results: The maximum diameters of the pulmonary lesions were not significantly different between the malignant and benign groups (p>0.05). Ki and SUVmax were significantly higher in malignant lesions compared to benign lesions (p<0.05). Ki was highly correlated with SUVmax in pulmonary lesions (r=0.815, p<0.01). The malignant lesions showed gradually increasing TAC, and benign lesions exhibited gradually decreasing curves. The parametric images of Ki were useful to distinguish malignant lesions from normal tissue.

Conclusion: Our results indicate that Ki parametric imaging in F-18-FDG PET/computed tomography (CT) dynamic multi-bed scanning may be useful in the differential diagnosis of pulmonary lesions.

语种: 英语
所属项目编号: NSFC 81071183 ; 2011YQ030114 ; 2011YQ03011409 ; BMU20120297 ; 110204 ; 120121
项目资助者: Natural Science Foundation of China ; Ministry of Science and Technology of China ; Research Fund for the Medicine and Engineering of Peking University ; Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, Department of Chemistry, Beijing Normal University, Beijing, China
WOS记录号: WOS:000331593700018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/61797
Appears in Collections:北京大学第一临床医学院_核医学科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100871, Peoples R China
2.Johns Hopkins Univ, Sch Med, Dept Radiol & Radiol Sci, Baltimore, MD USA

Recommended Citation:
Wang, Qiang,Wang, Rong-fu,Jianhua-Zhang,et al. Differential diagnosis of pulmonary lesions by parametric imaging in F-18-FDG PET/CT dynamic multi-bed scanning[J]. JOURNAL OF BUON,2013,18(4):928-934.
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