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学科主题临床医学
Differential diagnosis of pulmonary lesions by parametric imaging in F-18-FDG PET/CT dynamic multi-bed scanning
Wang, Qiang1; Wang, Rong-fu1; Jianhua-Zhang1; Zhou, Yun2
关键词cancer diagnosis F-18-FDG PET/CT parametric imaging pulmonary lesions
刊名JOURNAL OF BUON
2013-10-01
18期:4页:928-934
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CELL LUNG-CANCER ; TUMOR GLUCOSE-METABOLISM ; FDG-PET ; INPUT FUNCTION ; QUANTIFICATION ; IMAGES ; MANAGEMENT ; MODEL ; CT
英文摘要

Purpose: Benign and malignant pulmonary lesions are not easy to distinguish in a clinical setting. We investigated the feasibility of using parametric imaging of the rate constant Ki to diagnose the nature of pulmonary lesions.

Methods: Dynamic multi-bed scanning followed by a routine examination was performed on 21 patients with pulmonary lesions who were divided into two groups with malignant or benign lesions based on biopsy and follow-up. The number of patients in the malignant and benign groups were 10 with 15 lesions and 11 with 14 lesions, respectively. The left ventricular blood pool was used for an image-derived input function. The influx rate constant Ki of the pulmonary lesions and parametric images was generated with the Patlak plot method, and the inter-group differences for Ki, maximum standardized uptake value (SUVmax), and the time-activity curves (TAC) of fluorine-18-fludeoxyglucose (F-18-FDG) were analyzed. At the same time, we investigated the correlation of Ki to SUVmax.

Results: The maximum diameters of the pulmonary lesions were not significantly different between the malignant and benign groups (p>0.05). Ki and SUVmax were significantly higher in malignant lesions compared to benign lesions (p<0.05). Ki was highly correlated with SUVmax in pulmonary lesions (r=0.815, p<0.01). The malignant lesions showed gradually increasing TAC, and benign lesions exhibited gradually decreasing curves. The parametric images of Ki were useful to distinguish malignant lesions from normal tissue.

Conclusion: Our results indicate that Ki parametric imaging in F-18-FDG PET/computed tomography (CT) dynamic multi-bed scanning may be useful in the differential diagnosis of pulmonary lesions.

语种英语
WOS记录号WOS:000331593700018
项目编号NSFC 81071183 ; 2011YQ030114 ; 2011YQ03011409 ; BMU20120297 ; 110204 ; 120121
资助机构Natural Science Foundation of China ; Ministry of Science and Technology of China ; Research Fund for the Medicine and Engineering of Peking University ; Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, Department of Chemistry, Beijing Normal University, Beijing, China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/61797
专题北京大学第一临床医学院_核医学科
作者单位1.Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100871, Peoples R China
2.Johns Hopkins Univ, Sch Med, Dept Radiol & Radiol Sci, Baltimore, MD USA
推荐引用方式
GB/T 7714
Wang, Qiang,Wang, Rong-fu,Jianhua-Zhang,et al. Differential diagnosis of pulmonary lesions by parametric imaging in F-18-FDG PET/CT dynamic multi-bed scanning[J]. JOURNAL OF BUON,2013,18(4):928-934.
APA Wang, Qiang,Wang, Rong-fu,Jianhua-Zhang,&Zhou, Yun.(2013).Differential diagnosis of pulmonary lesions by parametric imaging in F-18-FDG PET/CT dynamic multi-bed scanning.JOURNAL OF BUON,18(4),928-934.
MLA Wang, Qiang,et al."Differential diagnosis of pulmonary lesions by parametric imaging in F-18-FDG PET/CT dynamic multi-bed scanning".JOURNAL OF BUON 18.4(2013):928-934.
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